Transmission pathways of Campylobacter jejuni between humans and livestock in rural Ethiopia are highly complex and interdependent DOI Creative Commons
Nitya Singh, Cecilie Thystrup, Bahar Mummed

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 3, 2025

Abstract Background Campylobacter jejuni and C. coli are the most common causes of bacterial enteritis worldwide whereas symptomatic asymptomatic infections associated with stunting in children low- middle-income countries. Little is known about their sources transmission pathways countries, particularly for infants young children. We assessed genomic diversity Eastern Ethiopia to determine attribution under 1 year age livestock (chickens, cattle, goats sheep) other humans (siblings, mothers). Results Among 287 isolates, 48 seven-gene sequence types (STs), including 11 previously unreported STs were identified. Within an ST, core genome multiple isolates differed fewer than five alleles. Many these do not belong reported high-resource settings, six global STs, only ST50 was found our study area. Isolates from same infant sample closely related, while those consecutive samples often displayed different suggesting rapid clearance new infection. Four models using profiling methods, assumptions estimation methods predicted that chickens primary reservoir infections. Infections transmitted or without (mothers, siblings) as intermediate sources. Model predictions terms relative importance cattle versus small ruminants additional Conclusions The area highly complex interdependent. While important , ruminant reservoirs also contribute currently nonculturable species Candidatus infans prevalent likely anthroponotic. Efforts reduce colonization ultimately low-resource settings best aimed at protecting proximate such caretakers’ hands, food indoor soil through tight integration siloed domains nutrition, safety water, sanitation hygiene.

Language: Английский

Transmission pathways of Campylobacter jejuni between humans and livestock in rural Ethiopia are highly complex and interdependent DOI Creative Commons
Nitya Singh, Cecilie Thystrup, Bahar Mummed

et al.

Gut Pathogens, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 3, 2025

Abstract Background Campylobacter jejuni and C. coli are the most common causes of bacterial enteritis worldwide whereas symptomatic asymptomatic infections associated with stunting in children low- middle-income countries. Little is known about their sources transmission pathways countries, particularly for infants young children. We assessed genomic diversity Eastern Ethiopia to determine attribution under 1 year age livestock (chickens, cattle, goats sheep) other humans (siblings, mothers). Results Among 287 isolates, 48 seven-gene sequence types (STs), including 11 previously unreported STs were identified. Within an ST, core genome multiple isolates differed fewer than five alleles. Many these do not belong reported high-resource settings, six global STs, only ST50 was found our study area. Isolates from same infant sample closely related, while those consecutive samples often displayed different suggesting rapid clearance new infection. Four models using profiling methods, assumptions estimation methods predicted that chickens primary reservoir infections. Infections transmitted or without (mothers, siblings) as intermediate sources. Model predictions terms relative importance cattle versus small ruminants additional Conclusions The area highly complex interdependent. While important , ruminant reservoirs also contribute currently nonculturable species Candidatus infans prevalent likely anthroponotic. Efforts reduce colonization ultimately low-resource settings best aimed at protecting proximate such caretakers’ hands, food indoor soil through tight integration siloed domains nutrition, safety water, sanitation hygiene.

Language: Английский

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