Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer DOI Creative Commons
Donatella Coradduzza, Andrea Sanna, Biagio Di Lorenzo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Prostate cancer is a leading cause of morbidity and mortality worldwide, with incidence rates projected to double between 2020 2040. This growing health challenge highlights the need for improved diagnostic strategies risk assessment tools better understand disease etiology progression. Among environmental factors, heavy metals have been implicated in inflammation carcinogenesis, yet their specific role prostate remains insufficiently explored. novel study analyses relationship metal concentrations plasma urine patients benign prostatic hyperplasia, precancerous lesions cancer. In addition evaluating key clinical parameters, including age, total PSA levels, hemoglobin monocyte/lymphocyte ratio, it aims determine whether contribute progression they can serve as potential biomarkers early diagnosis. Our findings reveal significant differences vanadium antimony plasma, suggesting pathophysiology. Notably, lower are associated an increased PC, while significantly higher PL group. Regression analysis further supports association highlighting copper or therapeutic targets health. The also explores impact lead exposure on risk, revealing concentration PC. These underscore complex interaction emphasizing research elucidate underlying mechanisms explore interventions.

Language: Английский

Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer DOI Creative Commons
Donatella Coradduzza, Andrea Sanna, Biagio Di Lorenzo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Prostate cancer is a leading cause of morbidity and mortality worldwide, with incidence rates projected to double between 2020 2040. This growing health challenge highlights the need for improved diagnostic strategies risk assessment tools better understand disease etiology progression. Among environmental factors, heavy metals have been implicated in inflammation carcinogenesis, yet their specific role prostate remains insufficiently explored. novel study analyses relationship metal concentrations plasma urine patients benign prostatic hyperplasia, precancerous lesions cancer. In addition evaluating key clinical parameters, including age, total PSA levels, hemoglobin monocyte/lymphocyte ratio, it aims determine whether contribute progression they can serve as potential biomarkers early diagnosis. Our findings reveal significant differences vanadium antimony plasma, suggesting pathophysiology. Notably, lower are associated an increased PC, while significantly higher PL group. Regression analysis further supports association highlighting copper or therapeutic targets health. The also explores impact lead exposure on risk, revealing concentration PC. These underscore complex interaction emphasizing research elucidate underlying mechanisms explore interventions.

Language: Английский

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