Siparuna gesnerioides and Siparuna guianensis Essential Oils in Aedes aegypti Control: Phytoanalysis, Molecular Insights for Larvicidal Activity and Selectivity to Non-Target Organisms DOI Creative Commons
Milton L. Montaño-Campaz, Eugênio E. Oliveira, Beatriz Toro-Restrepo

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(9), P. 1322 - 1322

Published: April 27, 2025

Synthetic insecticides are widely used against mosquitoes, but misuse has led to environmental and health concerns. Plant-derived alternatives, such as essential oils, seem offer a safer option, minimizing these problems without compromising efficacy. In this study, we evaluated the oil from Siparuna gesnerioides (Kunth) A.DC., Neotropical plant, for its effectiveness in controlling Aedes (Stegomyia) aegypti (Linnaeus) larvae, major vector of human diseases. We first assessed phytochemistry silico approaches predict potential physiological targets larvicidal activities. Selectivity assays were conducted with Belostoma anurum (Herrich-Schäffer), non-target predatory water bug. The constituents S. γ-elemene (45.8%) germacrene D (43.8%). This effectively killed larvae both susceptible resistant mosquito strains (LC50 = 0.070 μg/mL). However, concentrations more than 80% B. nymphs. Molecular modeling suggested that components (γ-elemene D) interact stably acetylcholinesterases (AChEs), indicating mechanism action. Our results reinforce oils control. Nevertheless, non-selective impact on predators, seen gesnerioides, highlights need caution field applications.

Language: Английский

Siparuna gesnerioides and Siparuna guianensis Essential Oils in Aedes aegypti Control: Phytoanalysis, Molecular Insights for Larvicidal Activity and Selectivity to Non-Target Organisms DOI Creative Commons
Milton L. Montaño-Campaz, Eugênio E. Oliveira, Beatriz Toro-Restrepo

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(9), P. 1322 - 1322

Published: April 27, 2025

Synthetic insecticides are widely used against mosquitoes, but misuse has led to environmental and health concerns. Plant-derived alternatives, such as essential oils, seem offer a safer option, minimizing these problems without compromising efficacy. In this study, we evaluated the oil from Siparuna gesnerioides (Kunth) A.DC., Neotropical plant, for its effectiveness in controlling Aedes (Stegomyia) aegypti (Linnaeus) larvae, major vector of human diseases. We first assessed phytochemistry silico approaches predict potential physiological targets larvicidal activities. Selectivity assays were conducted with Belostoma anurum (Herrich-Schäffer), non-target predatory water bug. The constituents S. γ-elemene (45.8%) germacrene D (43.8%). This effectively killed larvae both susceptible resistant mosquito strains (LC50 = 0.070 μg/mL). However, concentrations more than 80% B. nymphs. Molecular modeling suggested that components (γ-elemene D) interact stably acetylcholinesterases (AChEs), indicating mechanism action. Our results reinforce oils control. Nevertheless, non-selective impact on predators, seen gesnerioides, highlights need caution field applications.

Language: Английский

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