Electromagnetic-responsive targeted delivery scaffold technology has better potential to repair injured peripheral nerves: a narrative review DOI
Yutong Chen, Yan Xu, Seeram Ramakrishna

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(1), P. 51 - 71

Published: Sept. 1, 2024

Peripheral nerve injury with long size defects has been an urgent clinical challenge. With the development of bioengineering, nanotechnology and additive manufacturing technologies, biologic delivery systems have gradually shown great potential for treatment peripheral injury. The main problem general is that loading capacity biologics positively correlated release rate, it more difficult to achieve long-term stable high biologics-loaded scaffolds; thus, not possible carry out full-cycle targeted therapy sites. To solve these problems, mechanisms common neurotrophic factors, bioelectrical signals biomagnetic repairing are discussed in this paper. Moreover, review summarizes mechanism electroactive magnetoresponsive materials significant ability repair promote regeneration provides overview different structural dimensions. It was finally concluded electromagnetic responsive scaffolds (four-dimensional scaffolds) good ability, which guidance application

Language: Английский

Electromagnetic-responsive targeted delivery scaffold technology has better potential to repair injured peripheral nerves: a narrative review DOI
Yutong Chen, Yan Xu, Seeram Ramakrishna

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(1), P. 51 - 71

Published: Sept. 1, 2024

Peripheral nerve injury with long size defects has been an urgent clinical challenge. With the development of bioengineering, nanotechnology and additive manufacturing technologies, biologic delivery systems have gradually shown great potential for treatment peripheral injury. The main problem general is that loading capacity biologics positively correlated release rate, it more difficult to achieve long-term stable high biologics-loaded scaffolds; thus, not possible carry out full-cycle targeted therapy sites. To solve these problems, mechanisms common neurotrophic factors, bioelectrical signals biomagnetic repairing are discussed in this paper. Moreover, review summarizes mechanism electroactive magnetoresponsive materials significant ability repair promote regeneration provides overview different structural dimensions. It was finally concluded electromagnetic responsive scaffolds (four-dimensional scaffolds) good ability, which guidance application

Language: Английский

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