Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays DOI Creative Commons
Shunsuke Tomita, Chiaki Nagai‐Okatani

BBA Advances, Journal Year: 2024, Volume and Issue: 7, P. 100129 - 100129

Published: Dec. 8, 2024

Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their methods, including lectin microarray (LMA) one gold standards, fundamental principles underlying chemical noses/tongues explained various applications monosaccharides introduced. Then, similarities differences these two approaches discussed. While both aim to comprehensively profile biospecimens based on 'interaction patterns' between multiple recognition probes analytes, each has its own strengths. LMAs excel at specific, targeted analysis defined lectin-glycan interactions, whereas nose/tongue offers greater flexibility expandability in terms system design, making it well-suited discovering unknown profiles detecting broader mixtures. In future, chemical-nose/tongue may be applied niche areas become powerful that complement LMA techniques.

Language: Английский

Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays DOI Creative Commons
Shunsuke Tomita, Chiaki Nagai‐Okatani

BBA Advances, Journal Year: 2024, Volume and Issue: 7, P. 100129 - 100129

Published: Dec. 8, 2024

Chemical-nose/tongue technologies are emerging as promising analytical tools for glycan analysis. After briefly introducing the importance of glycans and their methods, including lectin microarray (LMA) one gold standards, fundamental principles underlying chemical noses/tongues explained various applications monosaccharides introduced. Then, similarities differences these two approaches discussed. While both aim to comprehensively profile biospecimens based on 'interaction patterns' between multiple recognition probes analytes, each has its own strengths. LMAs excel at specific, targeted analysis defined lectin-glycan interactions, whereas nose/tongue offers greater flexibility expandability in terms system design, making it well-suited discovering unknown profiles detecting broader mixtures. In future, chemical-nose/tongue may be applied niche areas become powerful that complement LMA techniques.

Language: Английский

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