Exploring predictors of the five-time sit-to-stand test based on cross-sectional findings from the Swedish National Study on Aging and Care (SNAC) DOI Creative Commons
Joakim Niklasson, Cecilia Fagerström, Sofia Backåberg

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Abstract Background As we age, staying physically active and reducing sedentary behavior becomes crucial. To understand how to achieve this, factors related daily physical function such as five-time sit-to-stand (STS) time should be explored. This study aimed investigate the associations between STS time, self-rated activity, function, health-related quality of life, mental health in community-dwelling older adults aged ≥ 60 years. Method Cross-sectional design with self-reported objectively measured data from years ( n = 819), acquired Swedish National Study on Aging Care. Data was analyzed through multiple linear regression. Results The model (R 2 0.268) showed that predicted by grip strength (β’ -0.204, p < 0.05), age 0.202, life -0.192, having fallen within preceding twelve months -0.127, activities perceived light moderate intensity -0.121, one-leg stand -0.099, education level -0.092, 0.05). For (β -0.354, confidence interval [CI] (-0.509)–(-0.199)), -0.222, CI (-0.365)–(-0.078)), -0.166, (-0.278)–(-0.053)) were most prominent predictors. Conclusion highlights importance predicting adults. Clinicians can use these insights develop interventions maintain regularly assessing monitoring factors. Future research explore relationship fall history, faster impact among

Language: Английский

Bioelectrical impedance analysis (BIA) -derived phase angle in sarcopenia: A systematic review DOI Creative Commons
Olivia Di Vincenzo, Maurizio Marra,

Ada Di Gregorio

et al.

Clinical Nutrition, Journal Year: 2020, Volume and Issue: 40(5), P. 3052 - 3061

Published: Nov. 1, 2020

Background & aimsBioelectrical impedance analysis-derived phase angle (PhA) has been gaining attention in the clinical evaluation of nutritional status because it is thought to be a proxy water distribution and body cell mass; also associated muscle strength an effective predictor different outcomes. Since association may expected between PhA sarcopenia (defined by low skeletal mass impaired function), aim this systematic review was evaluate: a) changes due sarcopenia; b) prevalence according values; c) derivation cut-offs for detecting d) as predictors outcomes.MethodsA research on electronic databases (PubMed, Embase, Scopus Web Science) from inception January 31st, 2020 performed PRISMA checklist. Using PICOS strategy, “P” corresponded participants any age, gender or ethnicity, “I” designated diagnosis sarcopenia, “C” indicated subjects without “O” PhA, “S” selected all study types. Methodological quality assessed using National Institute Health (NIH) assessment tool.ResultsThrough initial literature search after removing duplicates excluding papers screening titles abstracts, 79 potentially relevant studies were examined. Thirteen (7668 subjects) met inclusion criteria. The overall risk bias low. Sarcopenia with significant lower seven out eight, while five six reported high patients PhA. Different cut-off point values 4.05 5.05° have derived identification sarcopenia. independent survival cancer geriatric hospitalized patients.ConclusionsData demonstrate that decreased sarcopenic higher Further are needed determine what extent valuable and/or identifying

Language: Английский

Citations

191

Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults DOI
Everson Araújo Nunes,

Lauren M. Colenso‐Semple,

Sean McKellar

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(2), P. 795 - 810

Published: Feb. 20, 2022

Language: Английский

Citations

126

An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review DOI Creative Commons
Giulia Coletta, Stuart M. Phillips

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101883 - 101883

Published: Feb. 14, 2023

The definition of sarcopenia, the age-related loss muscle mass, has evolved since term's inception and yet there is no consensus. Many identified definitions sarcopenia centre their criteria around function, weakness. Common variables to various are appendicular lean soft tissue mass (often called mass), grip strength, gait speed. However, a lack consensus remains among operational diagnostics for this newly recognized disease may be attributed absence appropriate tools that accurately measure outcomes interest, such as skeletal instead mass. In narrative review, we describe evolution groups' address need more accurate measures effective, low-cost treatments (i.e., resistance training diet) disease. Consensus on what constitutes critical propel research in field and, importantly, provide prognostic value diagnosis provides how patient would treated.

Language: Английский

Citations

111

WHO working definition of vitality capacity for healthy longevity monitoring DOI
Ivan Bautmans, Veerle Knoop, Jotheeswaran Amuthavalli Thiyagarajan

et al.

The Lancet Healthy Longevity, Journal Year: 2022, Volume and Issue: 3(11), P. e789 - e796

Published: Nov. 1, 2022

Language: Английский

Citations

97

Muscle quality index is associated with trouble sleeping: a cross-sectional population based study DOI Creative Commons
Yanwei You, Yuquan Chen, Qi Zhang

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 14, 2023

Trouble sleeping is one of the major health issues nowadays. Current evidence on correlation between muscle quality and trouble limited.A cross-sectional study design was applied participants aged from 18 to 60 years in National Health Nutrition Examination Survey (NHANES) 2011-2014 used for analysis. Muscle index (MQI) quantitatively calculated as handgrip strength (HGS, kg) sum/ arm appendicular skeletal mass (ASM, by using sum non-dominant hand dominant hand. Sleeping data obtained interviews self-reported individuals. The main analyses utilized weighted multivariable logistic regression models according complex multi-stage sampling NHANES. Restricted cubic spline model explore non-linear relationship MQI sleeping. Moreover, subgroup concerning sociodemographic lifestyle factors were conducted this study.5143 finally included in. In fully adjusted model, an increased level significantly associated with a lower odds ratio sleeping, OR = 0.765, 95% CI: (0.652,0.896), p 0.011. showed association However, it seemed that prevalence decreased increasing until reached 2.362, after which plateau. Subgroup further confirmed negative consistent robust across groups.Overall, revealed can be reliable predictor Maintaining certain would beneficial sleep health. study, causal inference worthy exploration.

Language: Английский

Citations

74

Human skeletal muscle-specific atrophy with aging: a comprehensive review DOI
Masatoshi Naruse, Scott Trappe, Todd A. Trappe

et al.

Journal of Applied Physiology, Journal Year: 2023, Volume and Issue: 134(4), P. 900 - 914

Published: Feb. 24, 2023

Age-related skeletal muscle atrophy appears to be a group-specific process, yet only few specific muscles have been investigated and our understanding in this area is limited. This review provides comprehensive summary of the available information on age-related muscle-specific manner, nearly half which comes from quadriceps. Decline size over ∼50 yr aging was determined 47 cross-sectional studies 982 young (∼25 yr) 1,003 old (∼75 individuals nine groups: elbow extensors (−20%, −0.39%/yr), flexors (−19%, −0.38%/yr), paraspinals (−24%, −0.47%/yr), psoas (−29%, −0.58%/yr), hip adductors (−13%, −0.27%/yr), hamstrings quadriceps (−27%, −0.53%/yr), dorsiflexors (−9%, −0.19%/yr), triceps surae (−14%, −0.28%/yr). Muscle-specific rate also for each subcomponent hamstrings, quadriceps, surae. Of all included review, there more than fivefold difference between least (−6%, −0.13%/yr, soleus) most (−33%, −0.66%/yr, rectus femoris) atrophying muscles. Muscle activity level, fiber type, sex, timeline process appeared some influence atrophy. Given large range number that not investigated, could expand functional deficits develop with help guide interventions improve quality life women men.

Language: Английский

Citations

62

DNAmFitAge: biological age indicator incorporating physical fitness DOI Creative Commons
Kristen M. McGreevy, Zsolt Radák, Ferenc Torma

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(10), P. 3904 - 3938

Published: Feb. 22, 2023

Physical fitness is a well-known correlate of health and the aging process DNA methylation (DNAm) data can capture via epigenetic clocks. However, current clocks did not yet use measures mobility, strength, lung, or endurance in their construction. We develop blood-based DNAm biomarkers for parameters gait speed (walking speed), maximum handgrip forced expiratory volume one second (FEV1), maximal oxygen uptake (VO2max) which have modest correlation with five large-scale validation datasets (average r between 0.16-0.48). then these parameter DNAmGrimAge, mortality risk estimate, to construct DNAmFitAge, new biological age indicator that incorporates physical fitness. DNAmFitAge associated low-intermediate activity levels across (

Language: Английский

Citations

51

Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies DOI Creative Commons
Dequan Liu, Shijin Wang, Shuang Liu

et al.

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101270 - 101270

Published: April 6, 2024

The onset of sarcopenia is intimately linked with aging, posing significant implications not only for individual patient quality life but also the broader societal healthcare framework. Early and accurate identification a comprehensive understanding its mechanistic underpinnings therapeutic targets paramount to addressing this condition effectively. This review endeavors present cohesive overview recent advancements in research diagnosis. We initially delve into contemporary diagnostic criteria, specifically referencing European Working Group on Sarcopenia Older People (EWGSOP) 2 Asian (AWGS) 2019 benchmarks. Additionally, we elucidate assessment techniques muscle strength, quantity, physical performance, highlighting tools such as grip chair stand test, dual-energy X-ray Absorptiometry (DEXA), bioelectrical impedance analysis (BIA), gait speed, short performance battery (SPPB), while discussing their inherent advantages limitations. Such pave way early unequivocal diagnosis sarcopenia. Proceeding further, provide deep-dive sarcopenia's pathogenesis, offering thorough examination associated signaling pathways like Myostatin, AMP-activated protein kinase (AMPK), insulin/IGF-1 Signaling (IIS), nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) pathways. Each pathway's role mediation detailed, underscoring potential target avenues. From perspective, underscores pivotal mitochondrial dysfunction sarcopenia, emphasizing elements oxidative overload, biogenesis, mitophagy, significance. At last, capture strides made treatment, ranging from nutritional exercise interventions pharmacological supplementation strategies. In sum, meticulously synthesizes latest scientific developments aiming enhance precision clinical practice insights refined innovative interventions, ultimately contributing optimized care field.

Language: Английский

Citations

19

Effects of Acceptance and Commitment Therapy plus Exercise for Older Adults with Chronic Low Back Pain: A Preliminary Cluster Randomized Controlled Trial with Qualitative Interviews DOI Creative Commons

J. Liu,

Yim Wah Mak,

Aled Ly Tang

et al.

Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105350 - 105350

Published: Feb. 1, 2025

Language: Английский

Citations

2

Kinesiophobia and its correlations with pain, proprioception, and functional performance among individuals with chronic neck pain DOI Creative Commons
Faisal Asiri, Ravi Shankar Reddy, Jaya Shanker Tedla

et al.

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(7), P. e0254262 - e0254262

Published: July 8, 2021

Chronic neck pain (CNP) incidence in the general population is high and contributes to a significant health problem. Kinesiophobia (fear of movement or re-injury) combined with emotions physical variables may play vital role assessing managing individuals CNP. The study's objectives are 1) evaluate relationship between kinesiophobia, intensity, proprioception, functional performance; 2) determine if kinesiophobia predicts performance among CNP individuals. Sixty-four participants (mean age 54.31 ± 9.41) were recruited for this cross-sectional study. following outcome measures evaluated: using Tampa Scale (TSK), intensity visual analog scale (VAS), cervical proprioceptive joint position errors (in flexion, extension, rotation directions) range motion (CROM) device handgrip strength as measure Baseline® hydraulic hand dynamometer. showed strong positive correlation (r = 0.81, p<0.001), mild moderate proprioception (JPE) left right directions (p<0.05), but no flexion direction (p 0.127). Also, there was negative -0.65, p<0.001). Regression analysis proved that predictor (p<0.05). This study infers pain, performance. assessment should be considered regular clinical practice understand barriers can influence rehabilitation outcomes

Language: Английский

Citations

88