Association of liver fibrosis−4 index with functional outcomes in chinese patients with acute ischemic stroke undergoing mechanical thrombectomy

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

This study aimed to investigate the association between Fibrosis-4 (FIB-4) index and functional outcomes hemorrhagic complications in patients with large vessel occlusion acute ischemic stroke (LVO-AIS) treated mechanical thrombectomy (MT). In this single-center retrospective cohort study, we consecutively enrolled LVO-AIS who underwent MT January 2018 February 2024. The primary endpoint was poor outcome at 90 days (modified Rankin Scale score 3-6). Secondary endpoints included transformation (HT) symptomatic intracranial hemorrhage (sICH). Multivariable logistic regression models restricted cubic spline analyses were used evaluate FIB-4 after adjusting for potential confounders. Among 421 patients, 254 (60.33%) had outcomes, 197 (46.79%) developed HT, 76 (18.05%) experienced sICH. After adjustment confounding factors, each unit increase associated a 38% higher risk of (P = 0.013). showed significant nonlinearity (P-nonlinear 0.010), increasing exponentially beyond threshold 2.4. Advanced fibrosis (FIB-4 ≥ 2.67) independently 0.024). predicts patients. readily available biomarker may help identify high-risk could benefit from enhanced monitoring individualized treatment strategies.

Language: Английский

Is the FIB-4 score a prognostic factor in acute ischemic stroke patients receiving intravenous thrombolytic therapy?

Journal of Clinical Neuroscience, Journal Year: 2025, Volume and Issue: 136, P. 111251 - 111251

Published: April 23, 2025

Language: Английский

Is the Fib-4 Score a Prognostic Factor in Acute Ischemic Stroke Patients Receiving Intravenous Thrombolytic Therapy?

Published: Jan. 1, 2024

Language: Английский