Association of Daily Sitting Time and Leisure-Time Physical Activity with Sarcopenia Among Chinese Older Adults

Healthcare, Journal Year: 2025, Volume and Issue: 13(3), P. 251 - 251

Published: Jan. 27, 2025

Objectives: This study aimed to explore the independent and joint associations of daily sitting time leisure-time physical activity (LTPA) with sarcopenia among older adults. Methods: The participants were 847 community-dwelling adults aged 60 or from Beijing Shanghai, China. Sarcopenia was diagnosed based on criteria established by Asian Working Group for (2019). Daily LTPA self-reported using Physical Activity Scale Elderly (PASE). Logistics regression models used between time, LTPA, sarcopenia. To examine associations, classified levels. Final adjusted sociodemographic variables, lifestyle factors, chronic conditions. Results: Prolonged insufficient independently associated higher odds Among insufficiently active participants, 1–2 h, 2–4 more than 4 h per day 5.52-fold (95% CI: 1.13–26.83), 6.69-fold 1.33–33.59), 12.82-fold 2.75–59.85) increased sarcopenia, respectively, compared less 1 h. For those meeting guideline (≥150 min week), only significantly (OR: 7.25, 95% 1.99–26.36). Conclusions: sedentary behavior may not be offset achieving recommended levels activity.

Language: Английский

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Krill oil supplementation in vivo promotes increased fuel metabolism and protein synthesis in cultured human skeletal muscle cells

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 28, 2024

Introduction Krill oil is a dietary supplement derived from Antarctic krill; small crustacean found in the ocean. rich source of omega-3 fatty acids, specifically eicosapentaenoic acid and docosahexaenoic acid, as well antioxidant astaxanthin. The aim this study was to investigate effects krill supplementation, compared placebo (high oleic sunflower added astaxanthin), vivo on energy metabolism substrate turnover human skeletal muscle cells. Methods Skeletal cells (myotubes) were obtained before after 7-week or intervention, glucose leucine accumulation, different stimuli vitro , studied myotubes. functional data combined with proteomic transcriptomic analyses. Results In intervention increased oxidation accumulation cells, however no observed metabolism. oil-intervention-induced increase correlated negatively changes serum low-density lipoprotein (LDL) concentration. addition, myotubes also exposed . revealed that 24 h treatment both myotubes, enhancing utilization. Transcriptomic analysis comparing supplementation identified differentially expressed genes associated e.g., glycolysis/gluconeogenesis, metabolic pathways calcium signaling pathway, while demonstrated upregulation LDL-receptor intervention. Conclusion These findings suggest promotes fuel protein synthesis potential implications for health.

Language: Английский

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Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

Sarcopenic obesity (SO), characterized by the concurrent decline in muscle mass and 9 function alongside an increase body fat, has emerged as a pressing health concern 10 reaching 11% incidence worldwide (1). This multifaceted condition encompasses 11 intricate metabolic, physiological, molecular alterations that collectively elevate 12 risk of age-related diseases contribute to overall well-being (2). Within 13 this complex scenario, nutrition physical activity have been recognized pivotal 14 determinants ameliorate consequences SO (3, 4). The primary objective 15Research Topic was elucidate role exercise addressing 16 issue its connection with accelerated aging. 17The

Language: Английский

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Comparison of surgical efficacy between direct anterior approach and posterolateral approach in the treatment of sarcopenia with femoral neck fractures

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Language: Английский

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Associations of sarcopenia, obesity, and metabolic health with the risk of urinary incontinence in U.S. adult women: a population-based cross-sectional study

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 14, 2024

Introduction Urinary incontinence (UI) significantly impairs women’s quality of life. Identifying its risk factors is essential for developing effective interventions. Sarcopenia, characterized by the accelerated loss muscle mass and function, an emerging concern often linked to obesity abnormal metabolic status, exacerbating various adverse health outcomes. This population-based study aimed explore independent joint associations sarcopenia, obesity, with UI risk, as well evaluate mediating role indicators in these Methods A total 3,557 women aged ≥20 years from National Health Nutrition Examination Survey were included. Sarcopenia was assessed using appendicular lean index (ALMI), defined body waist circumference. Metabolic evaluated revised criteria Cholesterol Education Program-Adult Treatment Panel III. identified through responses “Kidney Conditions-Urology” questionnaire classified into stress (SUI), urgency (UUI), mixed (MUI). Multivariable logistic regression restricted cubic spline models used visualize relationship between ALMI UI. Mediation constructed assess indicators. Results We found that sarcopenia associated increased MUI general population. Age-specific analysis revealed factor SUI ≥60, 40–59 years. Sarcopenic particularly under central criteria, further elevated Notably, metabolically unhealthy obese phenotype at highest both MUI. Metabolically glycohemoglobin, vitamin D, serum albumin levels partial mediators associations. Conclusion Our findings elucidated complex interactions health, underscoring critical need integrated therapeutic strategies address targeted nutritional interventions, aiming enhance muscular effectively manage prevent

Language: Английский

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