Incidence and genetic risk of juvenile idiopathic arthritis in Norway by latitude DOI Creative Commons
Sigrid Hestetun, Hamid Khoshfekr Rudsari, Piotr Jahołkowski

et al.

Arthritis & Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Objective We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in three geographic regions Norway and whether potential regional differences are explained by environmental or genetic factors across regions. Methods conducted a register‐based cohort study including all Norwegian children born from 2004 2019, with follow‐up throughout 2020. The JIA diagnosis, defined at least two International Classification Diseases, Tenth Revision codes for JIA, was validated against medical records. rate (IR) hazard ratio (HR) were estimated North, Mid, South In subsample Mother, Father, Child Cohort Study (MoBa), risk assessed Results After median 9.1 (range 0.3–16.0) years follow‐up, we identified 1,184 patients 910,058 controls. IR JIA/100,000 person‐years 14.4 Norway, 25.9 North region, 17.9 Mid 12.5 region. HR (95% confidence interval [CI]) region 2.07 (1.77–2.43) 1.43 CI 1.23–1.67) compared Adjustments perinatal factors, socioeconomic status, early antibiotic exposure did not change our estimates substantially. MoBa (238 57,392 controls), association between birth no longer significant when adjusting factors. Conclusion found higher increasing latitude without evidence available explaining observed gradient. contrast, modified association, but further studies warranted.

Language: Английский

Paternal Inflammatory Bowel Disease and the Risk of Pregnancy Loss DOI
Sonia Friedman, Caroline Thingholm Thorarinsson, Mette Wod

et al.

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Only about 30% of conceptions end in live births, yet there are little data on paternal causes pregnancy loss. Men with inflammatory bowel disease may have multiple disease-related issues that affect fertility. We aimed to examine outcomes women undergoing assisted reproduction whose male partners had Crohn's or ulcerative colitis.

Language: Английский

Citations

4
A Longitudinal Post-authorization Safety Study of Golimumab in Treatment of Ulcerative Colitis: A Cohort Study in Denmark and Sweden, 2013–2021 DOI Creative Commons
Annette Kjær Ersbøll, Zhiping Huang,

Deanna Hill

et al.

Drug Safety, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Impact of prenatal and postnatal maternal IBD status on offspring’s risk of IBD: a population-based cohort study DOI
Linéa Bonfils, Gry Poulsen, Manasi Agrawal

et al.

Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332885

Published: July 25, 2024

Objective In utero exposure to maternal inflammation may impact immune system development and subsequent risk of disease. We investigated whether a diagnosis IBD before childbirth is linked higher in offspring compared with after childbirth. Further, we analysed paternal status for comparison. Design Using Danish health registers, identified all individuals born Denmark between 1997 2022 their legal parents, as well status. Cox proportional hazards regression analyses adjusted calendar period mode delivery were used estimate by Results Of 1 290 358 children, 10 041 (0.8%) had mothers 9985 Over 18 370 420 person-years, 3537 diagnosed IBD. Offspring an HR 6.27 (95% CI 5.21, 7.54) those without IBD, while 3.88 3.27, 4.60). Corresponding HRs 5.26 4.22, 6.56) among 3.73 3.10, 4.50) Conclusion greater when either parent was rather than later, emphasising genetic predisposition environmental factors

Language: Английский

Citations

3
Risk of inflammatory bowel disease following hospitalisation with infectious mononucleosis: nationwide cohort study from Denmark DOI Creative Commons
Anthony Ebert,

Shania Harper,

Marie Vibeke Vestergaard

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

Citations

3
Does Surgery Before Pregnancy in Women With Inflammatory Bowel Disease Increase the Risk of Adverse Maternal and Fetal Outcomes? A Danish National Cohort Study DOI
Sonia Friedman, Jan Nielsen, Niels Qvist

et al.

The American Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 119(9), P. 1875 - 1884

Published: Feb. 20, 2024

INTRODUCTION: Up to 15% of women with Crohn's disease (CD) or ulcerative colitis (UC) undergo bowel surgery before pregnancy, and there is little data on pregnancy outcomes in this population. We aimed assess maternal/fetal CD UC who underwent surgeries pregnancy. METHODS: In nationwide study, we included all pregnancies from 1997 2022 examined 6 categories used multilevel logistic regression compute crude adjusted odds ratios (aOR) 95% confidence intervals (95% CI) for the risk offspring complications did, vs did not, RESULTS: There were 833 3,150 prior 12,883 6,972 without surgery. For UC, was associated Cesarian section (C-section) (ileoanal pouch: aOR: 20.03 [95% CI 10.33–38.83]; functional ileostomy: aOR:8.55 [6.10–11.98]; diverting 38.96 [17.05–89.01]) preterm birth (aOR: 2.25 [1.48–3.75]; 3.25 [2.31–4.59]; 2.17 [1.17–4.00]) respectively. intestinal surgery, risks C-section 1.94 [1.66–2.27]), 1.30 [1.04–1.61]), low 5-minute Apgar 1.95 1.07–3.54]) increased premature rupture membranes 0.68 [0.52–0.89]) decreased. only perianal 3.02 [2.31–3.95]) gestational hypertension/preeclampsia/eclampsia 0.52 [0.30–0.89]) DISCUSSION: Providers should be aware an likelihood certain perinatal patients

Language: Английский

Citations

2
Drug Repurposing in Crohn’s Disease Using Danish Real-World Data DOI Creative Commons
Saeed Shakibfar, Kristine H. Allin, Tine Jess

et al.

Pragmatic and Observational Research, Journal Year: 2024, Volume and Issue: Volume 15, P. 17 - 29

Published: Feb. 1, 2024

Drug repurposing, utilizing electronic healthcare records (EHRs), offers a promising alternative by repurposing existing drugs for new therapeutic indications, especially patients lacking effective therapies. Intestinal fibrosis, severe complication of Crohn's disease (CD), poses significant challenges, increasing morbidity and mortality without available pharmacological treatments. This article focuses on identifying medications associated with an elevated or reduced risk fibrosis in CD through population-wide real-world data artificial intelligence (AI) approach.

Language: Английский

Citations

2
The use of opioids nine months after surgery for Crohn's disease – a nationwide cohort study DOI Creative Commons
Bente Mertz Nørgård, Caroline Thingholm Thorarinsson, Floor Dijkstra Zegers

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(1), P. 52 - 60

Published: May 1, 2024

Summary Background The risk of chronic opioid use after surgery for Crohn's disease (CD) is not known. Aim aim this study to examine the according age at time and prior surgery. Methods This nationwide cohort included patients with a first CD (January 1, 1996 through 2021). We examined prescribed opioids 9 months estimated adjusted odds ratios (OR) in elderly (≥60 years), adults (≥40 <60 young (≥18 <40 years) Chronic was defined as prescriptions least two three consecutive quarters. Results A total 797 had elderly, 1603 adults, 2786 adults. Across all groups, 18%–38% received throughout surgery, if were If corresponding proportions 2%–5%. (≥1) ORs (95% CIs) their 10.37 (6.77–15.88), 10.48 (7.74–14.19), 6.55 (4.93–8.72), respectively. Conclusion Clinicians should be aware that need before may change opioids. Future research effective analgesic strategies help minimise population.

Language: Английский

Citations

2
Risk of anxiety, depression, and ADHD in pediatric patients with inflammatory bowel disease: A population-based cohort study DOI Creative Commons

Rebecca Kristine Kappel,

Tania Hviid Bisgaard, Gry Poulsen

et al.

Clinical and Translational Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 7, 2023

Abstract Introduction: Inflammatory bowel disease (IBD) is associated with depression and anxiety in adults, but data scarce on risk of psychiatric diseases children IBD. We aimed to estimate the anxiety, depression, or attention-deficit/hyperactivity disorder patients pediatric-onset Methods: performed a nationwide, register-based cohort study including all IBD diagnosed Denmark period 1998-2018, resulting 3,559 matched 1:5 age, sex, municipality residence, time period, 17,795 reference individuals. used Cox regression calculate hazard ratios for each outcome following diagnosis Results: Patients had an increased (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.26-1.80) using antidepressants (HR 1.54, CI 1.39-1.71), surprisingly reduced methylphenidate 0.75, 0.58-0.98). both subtypes (Crohn’s [CD] ulcerative colitis [UC]) developing which was particularly high CD 1.73, 1.35-2.22). UC 0.63, 0.43-0.93) – though not statistically significant being ADHD compared background population. Discussion: have 50% important health care providers be aware manage. Remarkably, we found receiving ADHD, merits further investigation.

Language: Английский

Citations

5
Use of Tramadol vs Traditional Opioids and Adverse Outcomes in Patients with Inflammatory Bowel Disease: A Danish Nationwide Cohort Study DOI
Rahul S. Dalal, Ken Lund, Floor Dijkstra Zegers

et al.

Inflammatory Bowel Diseases, Journal Year: 2023, Volume and Issue: 30(7), P. 1121 - 1129

Published: July 31, 2023

Use of traditional opioids (TOs) for pain management has been associated with adverse outcomes among patients inflammatory bowel diseases (IBDs). It is unknown if similar associations exist tramadol, a partial opioid agonist and serotonin norephinephrine reuptake inhibitor. We sought to compare tramadol vs TOs in an IBD population.

Language: Английский

Citations

4
Prior Appendectomy Is Associated With a Milder Clinical Course in Crohn’s Disease: A Nationwide Population-based Cohort Study DOI
Anders Mark‐Christensen, Eskild Bendix Kristiansen, Søren Laurberg

et al.

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: 31(1), P. 123 - 130

Published: April 2, 2024

Appendectomy may affect the clinical course of Crohn's disease (CD), but rigorous evidence is sparse and contradicting. The aim this study was to examine association between appendectomy CD.

Language: Английский

Citations

1