Glucose‐lowering drug use in migrants and native Danes with type 2 diabetes: Disparities in combination therapy and drug types DOI Creative Commons
Anders Aasted Isaksen, Annelli Sandbæk, Mette Vinther Skriver

et al.

Diabetes Obesity and Metabolism, Journal Year: 2023, Volume and Issue: 25(11), P. 3307 - 3316

Published: Aug. 7, 2023

To examine disparities in glucose-lowering drug (GLD) usage between migrants and native Danes with type 2 diabetes (T2D).In a nationwide, register-based cross-sectional study of 253 364 individuals prevalent T2D on December 31, 2018, we examined user prevalence during 2019 (i) GLD combination therapies (ii) individual types. Migrants were grouped by origin (Middle East, Europe, Turkey, Former Yugoslavia, Pakistan, Sri Lanka, Somalia, Vietnam), relative risk (RR) versus was computed using robust Poisson regression to adjust for clinical socioeconomic characteristics.In 2019, 34.7% received therapy, lower most migrant groups (RR from 0.78, 95% confidence interval CI 0.71-0.85 [Somalia group] 1.00, 0.97-1.04 [former Yugoslavia group]). Among Danes, the widely used oral metformin (used 62.1%), followed dipeptidyl peptidase-4 inhibitors (13.3%), sodium-glucose cotransporter-2 (11.9%) sulphonylureas (5.2%), higher use any GLD: 0.99, 0.97-1.01 [Europe 1.09, 1.06-1.11 [Sri Lanka Furthermore, 18.7% insulins 13.3% glucagon-like peptide-1 receptor agonists (GLP-1RAs), but less insulins: 0.66, 0.62-0.71 0.94, 0.89-0.99 group]; RR GLP-1RAs: 0.29, 0.22-0.39 0.95, 0.89-1.01 group]).Disparities types therapy evident Danes. more likely GLDs injection-based GLDs, particularly GLP-1RAs, which may contribute complication mortality among this group.

Language: Английский

Trends in cause-specific mortality among people with type 2 and type 1 diabetes from 2002 to 2019: a Danish population-based study DOI Creative Commons
Tinne Laurberg, Susanne Boel Graversen, Annelli Sandbæk

et al.

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 41, P. 100909 - 100909

Published: April 26, 2024

BackgroundDespite advances in primary and secondary prevention of cardiovascular disease, excess mortality persists within the diabetes population. This study explores components this their interaction with sex.MethodsUsing Danish registries (2002–2019), we identified residents aged 18–99 years, status, recorded causes death. Applying Lexis-based methods, computed age-standardized rates (asMRs), relative risks (asMRRs), log-linear trends for cause-specific mortality.FindingsFrom 2002 to 2019, 958,278 individuals died Denmark (T2D: 148,620; T1D: 7830) during 84.4 M person-years. During period, overall asMRs declined, driven by reducing mortality, notably men T2D. Conversely, cancer remained high, making leading cause death Individuals T2D faced an elevated risk from nearly all types, ranging 9% 257% compared non-diabetic counterparts. Notably, obesity-related cancers exhibited highest risks: liver (Men: asMRR 3.58 (3.28; 3.91); Women: 2.49 (2.14; 2.89)), pancreatic 3.50 (3.25; 3.77); 3.57 (3.31; 3.85)), kidney 2.10 (1.84; 2.40); 2.31 (1.92; 2.79)). In type 2 diabetes, stable, except dementia. women, diabetes-related increased 6–17% per decade across death, disease.InterpretationIn last decade, has emerged as among Denmark, emphasizing need management strategies incorporating prevention. A sex-specific approach is crucial address persistently higher women diabetes.FundingSupported Steno Diabetes Center Aarhus, which partially funded unrestricted donation Novo Nordisk Foundation, The Academy.

Language: Английский

Citations

7
Risk factor analysis for a rapid progression of chronic kidney disease DOI Creative Commons
Anne Høy Seemann Vestergaard, Simon Kok Jensen, Uffe Heide‐Jørgensen

et al.

Nephrology Dialysis Transplantation, Journal Year: 2024, Volume and Issue: 39(7), P. 1150 - 1158

Published: Jan. 2, 2024

ABSTRACT Background Chronic kidney disease (CKD) is a growing global health concern. Identifying individuals in routine clinical care with new-onset CKD at high risk of rapid progression the imperative to guide allocation prophylactic interventions, but community-based data are limited. We aimed examine progression, failure, hospitalization and death among adults incident stage G3 clarify association between predefined markers progression. Methods Using plasma creatinine measurements for entire Danish population from both hospitals primary care, we conducted nationwide, population-based cohort study, including Denmark 2017–2020. estimated 3-year risks (defined by confirmed decline glomerular filtration rate ≥5 mL/min/1.73 m2/year), all-cause death. To markers, constructed heat map showing based on markers: albuminuria, sex, diabetes hypertension/cardiovascular disease. Results Among 133 443 G3, was 14.6% [95% confidence interval (CI) 14.4–14.8]. The were 0.3% (95% CI 0.3–0.4), 53.3% 53.0–53.6) 18.1% 17.9–18.4), respectively. In map, ranged 7% females without or diabetes, 46%–47% males severe Conclusion This study shows that associated considerable morbidity setting underscores need optimized interventions such patients. Moreover, our highlight potential using easily accessible identify who

Language: Английский

Citations

4
Continuity of care across sectors in patients with type 2 diabetes: A nationwide register study in Denmark DOI Creative Commons
Anne Sofie Baymler Lundberg, Claus Høstrup Vestergaard, Annelli Sandbæk

et al.

Primary care diabetes, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Our aims were to describe health care utilisation patterns across sectors in patients with type 2 diabetes(T2D), and identify patient characteristics associated low continuity of care. A nationwide register-based cohort study including all Danish citizens recorded a diagnosis T2 diabetes 2017. The outcome was as measured by three different indices: the Continuity Care Index (COCI), Usual Provider (UPC), Sequential (SECON). median T2D had 75 % their contacts usual provider. strongest association number comorbidities, showing dose response trend. Other duration (>10.3 years), lower age group (40-49 having high education level (>15 years) cancer comorbidity. first step flag at potential risk fragmented due many transitions between providers. This is importance for general practitioners, who are coordinators various conditions contacts.

Language: Английский

Citations

0
The prognostic role of Fibrosis-4 score in heart failure with reduced ejection fraction DOI Creative Commons
Abdullahi Ahmed Mohamed, Daniel Christensen, Milan Mohammad

et al.

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 133174 - 133174

Published: March 1, 2025

Language: Английский

Citations

0
The risk of new-onset type 2 diabetes and the influence of risk factors among men with prostate cancer in the Danish Diet, Cancer, and Health study DOI Creative Commons

Jeppe Lyngbye Widding,

Monika Barsøe,

Gunn Ammitzbøll

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

Citations

0
Increasing Medication Use and Polypharmacy in Type 2 Diabetes: The Danish Experience From 2000 to 2020 DOI
Karl Sebastian Johansson, Espen Jimenez‐Solem, Tonny Studsgaard Petersen

et al.

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(12), P. 2120 - 2127

Published: May 6, 2024

OBJECTIVE Type 2 diabetes often coexists with other conditions that are amenable to pharmacological treatment. We hypothesized polypharmacy among individuals type has increased since 2000. RESEARCH DESIGN AND METHODS Using Danish national registries, we established a cohort of all (aged ≥18 years) between 2000 and 2020. analyzed their medication use prevalence varying degrees (≥5 or ≥10 medications), stratifying by age, sex, number chronic diseases, socioeconomic status. RESULTS The grew from 84,917 patients in 307,011 2020, totaling 461,849 unique patients. daily medications used per patient (mean ± SD) 3.7 2.8 (in 2000) 5.3 3.2 2020). lifetime risk was substantial, 89% (n = 409,062 461,849) being exposed ≥5 at some point 47% 217,467 medications. increases were driven an expanding group medications, analgesics, antihypertensives, proton pump inhibitors, statins having the largest net increase. Advanced male lower status, ethnicity positively correlated but could not explain overall increase polypharmacy. CONCLUSIONS Medication have diabetes. Although implications appropriateness this uncertain, results stress increasing need for health care personnel understand potential risks associated polypharmacy, including interactions, adverse effects, over- underprescribing.

Language: Английский

Citations

3
Periodontitis and Diabetes Complications: A Danish Population-Based Study DOI
Fernando Valentim Bitencourt,

A. Andersen,

Lasse Bjerg

et al.

Journal of Dental Research, Journal Year: 2024, Volume and Issue: 103(9), P. 870 - 877

Published: Aug. 1, 2024

Conflicting evidence suggests a link between diabetes-related microvascular complications and periodontitis. Reliable estimates have been hindered by small sample sizes residual confounding. Moreover, the combined effects of dyslipidemia on periodontitis not explored. Therefore, this study aimed to investigate association individual diabetic (i.e., neuropathy retinopathy) moderate/severe in Danish population-based study. In addition, we assessed whether modified these associations. This comprised 15,922 participants with type 2 diabetes from Health Central Denmark Multinomial logistic regression was used estimate odds ratios (ORs) 95% confidence intervals (CIs) for joint complications. The models adjusted potential confounders, including sociodemographic factors, lifestyle behaviors, health conditions. Inverse probability treatment weighting (IPTW) balanced measured confounders nonperiodontitis participants. Sensitivity analyses tested findings' robustness estimating E-values unmeasured confounding varying complication definitions. After IPTW, revealed that (OR 1.36, CI 1.14 1.63) retinopathy 1.21, 1.03 1.43) were significantly associated coexistence increased 1.5-fold 1.51, 1.23 1.85). An effect modification an additive scale found, indicated positive relative excess risk due interaction 0.24 neuropathy, 0.11 retinopathy, 0.44 both analysis ruled out definitions as explanatory factors. Diabetic individually combined, had complications, elevating These findings may aid identifying at-risk subgroups periodontitis, optimizing efforts mitigate disease burden.

Language: Английский

Citations

3
HbA1c-defined prediabetes and progression to type 2 diabetes in Denmark: A population-based study based on routine clinical care laboratory data DOI Creative Commons
Sia Kromann Nicolaisen, Lars Pedersen, Daniel R. Witte

et al.

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 203, P. 110829 - 110829

Published: July 13, 2023

To estimate the prevalence, incidence, mortality, and risk of progression to type 2 diabetes for individuals with HbA1c-defined prediabetes based on Danish nationwide population-based laboratory databases.We included all HbA1c measurements from general practice hospitals during 2012 2018. We estimated cumulative incidence having at least one measurement. The prevalence rates (HbA1c 42-47 mmol/mol) were examined in adult population. 5-year was death as competing event.Among 4,979,590 Danes, 70.8% (95% CI 70.8-70.9) had measurement 7.1% 7.1-7.1) rate 14.2 14.1-14.3) per 1,000 person-years, median age 66.9 years (IQR 56.7-75.7) 43 mmol/mol 42-44) diagnosis. Within five years, 17.5% 17.3-17.7) died 21.3% 21.1-21.5).Out 100 adults, 1.4 develop each year they can be identified an early stage databases. progresses six dies.

Language: Английский

Citations

5
Risk of Bleeding and Venous Thromboembolism after Colorectal Cancer Surgery in Patients with and without Type 2 Diabetes: A Danish Cohort Study DOI Creative Commons
F. Kristensen, Erzsébet Horváth‐Puhó,

Szimonetta Komjáthiné Szépligeti

et al.

TH Open, Journal Year: 2024, Volume and Issue: 08(01), P. e146 - e154

Published: Jan. 1, 2024

Abstract Background Bleeding and venous thromboembolism (VTE) are adverse outcomes after colorectal cancer (CRC) surgery. Type 2 diabetes (T2D) clusters with bleeding VTE risk factors. We examined the in patients T2D undergoing CRC surgery prognosis these outcomes. Methods conducted a prognostic population-based cohort study of 48,295 without for incident during 2005 to 2019. Patients were diagnosed hospital setting or had redeemed glucose-lowering drug prescription; remaining was diabetes. estimated 30-day 1-year risks used Fine–Gray model compute age-, sex-, calendar year-adjusted subdistribution hazard ratios (SHRs). The Kaplan–Meier method calculate mortality VTE. Results Within 30 days surgery, 2.7% 2.0% (SHR: 1.30 [95% confidence interval [CI]: 1.10–1.53]). For VTE, 0.6% 1.01 CI: 0.71–1.42]). SHRs within 1 year similar. 26.0% versus 24.9% 25.8% 27.5% diabetes, respectively. Conclusion Although absolute low, have an increased but not

Language: Английский

Citations

1
The effect of influenza vaccination on the rate of dementia amongst older adults DOI Creative Commons
Andreas Moses Appel, Janet Janbek, Christina Jensen‐Dahm

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(12)

Published: Oct. 6, 2024

Abstract Background and Purpose Previous studies have reported conflicting results regarding the association between influenza vaccination dementia. This was investigated in a nationwide register‐based cohort study. Methods Using registries, dementia‐free adults aged ≥65 years Denmark from 2002 to 2018 without previous vaccinations were included. Poisson regression facilitated confounder‐adjusted comparisons of dementia rates for ever versus never vaccinated, number within/after 5 first vaccination. Sensitivity analyses included stratification on age sex. Results Vaccination during follow‐up associated with slightly higher rate when adjusted sociodemographic factors comorbidities, both within after (incidence ratio [IRR] 1.04; 95% confidence interval [CI] 1.03–1.05). The decreased increasing vaccinations. highest amongst those only one (IRR 1.14; CI 1.12–1.17) six or more 0.95; 0.93–0.97). Applying same models control outcomes hip fracture cancer resulted vaccinated people 6% 7%, respectively. Vaccinated also had 10% mortality rate. Discussion Our do not support case preventive effect risk general population, as by some studies. However, found this study is probably due residual confounding, indicated mortality.

Language: Английский

Citations

1