Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10681 - 10697
Published: Dec. 1, 2024
Osteoarthritis (OA) is a common age-related joint disease characterized by destruction and impaired quality of life. Angiogenesis plays vital role in OA progression. This study aimed to identify key angiogenesis-related genes (ARGs) using transcriptomic machine learning methods.
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 28, 2024
This study employed Mendelian Randomization (MR) to investigate the causal relationships among immune cells, COPD, and potential metabolic mediators. Utilizing summary data from genome-wide association studies, we analyzed 731 cell phenotypes, 1,400 plasma metabolites, COPD. Bidirectional MR analysis was conducted explore links between cells complemented by two-step mediation multivariable identify mediating metabolites. Causal were identified 41 phenotypes with 6 exhibiting reverse causality. Additionally, 21 metabolites causally related Through analyses, 8 found have COPD mediated (including one unidentified), 1-methylnicotinamide levels showing highest proportion at 26.4%. We These findings contribute screening of individuals high risk for offer insights into early prevention precocious diagnosis Pre-COPD.
Language: Английский
Citations
4
International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 245 - 257
Published: Feb. 1, 2025
Objective: Observational studies have indicated that immune cells and circulating inflammatory proteins may play a dual role in the progression of COPD; however, precise mechanisms remain uncertain. The objective this study was to ascertain causal relationship between COPD quantify potential as mediators. Methods: A two-sample Mendelian randomisation analysis conducted involving 731 cells, 91 COPD, utilising summary-level data from genome-wide association studies. relationships were sequentially analysed by multivariate validated using Bayesian weighted randomisation. Subsequently, sensitivity analyses conducted, employing Cochran's Q test assess heterogeneity, MR-PRESSO MR-Egger tests pleiotropy, reverse MR Steiger directionality rule out causality. Lastly, two-step approach employed proportion mediate cell-mediated effects COPD. Results: combination inverse variance weighting method algorithm identified 30 found be causally associated with well eight By analysis, six cell phenotypes on CXCL10 having highest percentage mediation at 14.49%, followed IL20RA 11.47%. Conclusion: This provides comprehensive investigation an estimation effect These findings facilitate identification individuals high risk offer novel insights for early prevention clinical intervention. Keywords: randomization, proteins,
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9001 - 9001
Published: Aug. 19, 2024
Chronic obstructive pulmonary disease (COPD) and lung cancer represent formidable challenges in global health, characterized by intricate pathophysiological mechanisms multifaceted progression. This comprehensive review integrates insights from diverse perspectives to elucidate the roles of long non-coding RNAs (lncRNAs) pathogenesis COPD cancer, focusing on their diagnostic, prognostic, therapeutic implications. In context COPD, dysregulated lncRNAs, such as NEAT1, TUG1, MALAT1, HOTAIR, GAS5, emerge pivotal regulators genes involved Their identification, profiling, correlation with severity present promising avenues for prognostic diagnostic applications, thereby shaping personalized interventions. These lncRNAs are also implicated underscoring potential across both diseases. domain play modulatory progression, offering innovative approaches indicators. LncRNA-mediated immune responses have been shown drive progression modulating tumor microenvironment, influencing cell infiltration, altering cytokine production. dysregulation significantly contributes growth, metastasis, chemo-resistance, emphasizing significance targets markers. summarizes transformative lncRNA-based diagnostics therapeutics valuable into future research directions clinical translation development.
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10681 - 10697
Published: Dec. 1, 2024
Osteoarthritis (OA) is a common age-related joint disease characterized by destruction and impaired quality of life. Angiogenesis plays vital role in OA progression. This study aimed to identify key angiogenesis-related genes (ARGs) using transcriptomic machine learning methods.
Language: Английский
Citations
1