Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis DOI Creative Commons
Mario Cazzola, Clive P. Page, Paola Rogliani

et al.

Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Chronic obstructive pulmonary disease new pharmacological treatments and their relationship with cardiovascular effects DOI Open Access

Luis P. Dávil,

E. Gallardo,

Francisca A. Loaiza

et al.

International Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 13(5), P. 2234 - 2240

Published: April 29, 2025

Chronic obstructive pulmonary disease (COPD) is considered a progressive inflammatory condition that often complicated by one or more cardiovascular diseases (CVD). This review explores the impacts of current anti-inflammatory therapies have shown high relevance in COPD. Phosphodiesterase (PDE) inhibitors may offer effects with improved lung function, but produce cardiac arrhythmias when PDE3 inhibited, although PDE4 reduce events improving endothelial function and reducing thrombosis. Similarly, p38 mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) target COPD-related inflammation benefit patients COPD CVD. MAPK fibrosis, improve contractility, arrhythmia risk. PI3K PI3K/Akt pathway, which drives atherosclerosis thus potentially mitigate both plaque instability fibrosis. Biologic therapies, including monoclonal antibodies inhibit IL-5, IL-13/IL-4, thymic stromal lymphopoietin, IL-33, IL-17A, are promising exacerbations, require tight monitoring due to their immunomodulatory effects. Single-target neutrophil elastase matrix metalloproteinases show limited efficacy COPD, help stabilizing atherosclerotic plaques promoting vascular smooth muscle cell proliferation. Alpha-1 antitrypsin replacement therapy promising, exacerbations providing protection, especially myocardial injury.

Language: Английский

Citations

0
Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

Citations

3