Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155673 - 155673
Published: April 22, 2024
Language: Английский
APOPTOSIS, Journal Year: 2022, Volume and Issue: 28(1-2), P. 55 - 80
Published: Nov. 11, 2022
Language: Английский
Citations
78
Autophagy, Journal Year: 2023, Volume and Issue: 20(1), P. 151 - 165
Published: Aug. 31, 2023
AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff RTECs: renal tubular epithelial cells; SAKI: sepsis-induced Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine.
Language: Английский
Citations
64
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: May 29, 2024
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis, dynamics, mitophagy, which have garnered increasing attention from researchers unveil specific molecular mechanisms. this review, we present comprehensive summary of primary mechanisms functions regulators involved major components MQC. Furthermore, critical regulated by MQC its diverse roles progression systemic diseases been described detail. We discuss agonists antagonists targeting MQC, aiming explore potential therapeutic research prospects enhancing stabilize function.
Language: Английский
Citations
32
Food & Function, Journal Year: 2022, Volume and Issue: 13(18), P. 9576 - 9588
Published: Jan. 1, 2022
Heart failure (HF) is a clinical syndrome characterized by typical symptoms that usually occur at the end stage of various heart diseases and lead to death. Daidzein (DAI), an isoflavone found in soy foods, widely used treat menopausal syndrome, prostate cancer, breast disease, cardiovascular osteoporosis, has anti-oxidant anti-inflammatory properties. However, effects DAI HF remain unknown. In this study, doxorubicin (DOX) was establish models C57BL/6J mice H9c2 cells with treatment. Our results showed markedly improved DOX-induced decline cardiac function, decreased left ventricular ejection fraction, inflammation, oxidative stress, apoptosis, fibrosis. Mechanistically, affects energy metabolism regulating SIRT3, meets ATP demand improving glucose, lipid, ketone body as well restoring mitochondrial dysfunction vivo vitro. Additionally, can exert antioxidant function alleviate through SIRT3/FOXO3a pathway. conclusion, we demonstrate alleviates cardiotoxicity reducing apoptosis fibrosis, indicating its potential application for
Language: Английский
Citations
48
Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14
Published: May 9, 2022
Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, mediating the longevity effect of caloric restriction. In last decade, sirtuins have also been suggested to exert mitochondrial quality control mitophagy, which targets damaged mitochondria delivers them lysosomes for degradation. This is especially significant because dysfunctional accumulate in organisms. Accordingly, it has mitophagy many common interactive aspects process. article reviews mechanisms pathways sirtuin family-mediated further discusses its role diseases.
Language: Английский
Citations
42
Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 180, P. 63 - 74
Published: Jan. 11, 2022
Language: Английский
Citations
41
Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 943 - 943
Published: June 5, 2023
Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, focus changed from investigating natural role as transducer biological time for physiological systems to hypothesized roles virtually all clinical conditions. This goes along with appearance extensive literature claiming (generally) positive benefits high doses melatonin animal models and various situations would not be receptor-mediated. Based on assumption safe, have been administered patients, including elderly children, trials. this review, we critically review corresponding literature, hypotheses acts scavenger molecule, particular mitochondria, by trying only contextualize these interests but also attempting separate wheat chaff (or wishful thinking facts). We conclude most claims remain experimental evidence used promote them limited sometimes flawed. Our will hopefully encourage researchers reflect what can cannot do help move field forward solid basis.
Language: Английский
Citations
39
PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14952 - e14952
Published: March 13, 2023
Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease acute myocardial infarction. However, can lead ischemia injury (MIRI), which the prognosis of patients. Studying mechanisms MIRI help us improve treatment MIRI. The pathological process involves many ferroptosis mitophagy. Ferroptosis exacerbate MIRI, regulation mitophagy alleviate Both are closely related ROS, but there no clear understanding relationship between In this review, we analyzed according role mTOR, NLPR3 HIF. addition, simultaneous may be superior single for We summarized potential drugs that regulate and/or ferroptosis, hoping provide reference development methods treatment.
Language: Английский
Citations
26
Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: May 20, 2024
Mitochondrial dysfunction contributes to cerebral ischemia-reperfusion (CI/R) injury, which can be ameliorated by Sirtuin-3 (SIRT3). Under stress conditions, the SIRT3-promoted mitochondrial functional recovery depends on both its activity and expression. However, approach enhance SIRT3 after CI/R injury remains unelucidated. In this study, Sprague-Dawley (SD) rats were intracranially injected with either adeno-associated viral Sirtuin-1 (AAV-SIRT1) or AAV-sh_SIRT1 before undergoing transient middle artery occlusion (tMCAO). Primary cortical neurons cultured transfected lentiviral SIRT1 (LV-SIRT1) LV-sh_SIRT1 respectively oxygen-glucose deprivation/reoxygenation (OGD/R). Afterwards, treated a selective inhibitor, 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP). The expression, function, related mechanism of investigated Western Blot, flow cytometry, immunofluorescence staining, etc. After expression decreased in vivo vitro. simulation immune-analyses reported strong interaction between mitochondria CI/R. overexpression enhanced increasing deacetylation SIRT3, CI/R-induced infarction, neuronal apoptosis, oxidative stress, neurological motor dysfunction, respiratory chain promoted biogenesis, retained integrity morphology. Meanwhile, alleviated OGD/R-induced death bioenergetic deficits. These effects reversed neuroprotective partially offset 3-TYP. results suggest that restores structure function activating offering neuroprotection against signifies potential for clinical management ischemia.
Language: Английский
Citations
12
Redox Biology, Journal Year: 2024, Volume and Issue: 74, P. 103224 - 103224
Published: June 8, 2024
Silicosis, characterized by interstitial lung inflammation and fibrosis, poses a significant health threat. ATII cells play crucial role in alveolar epithelial repair structural integrity maintenance. Inhibiting cell senescence has shown promise silicosis treatment. However, the mechanism behind silica-induced remains elusive. The study employed male C57BL/6 N mice A549 human to investigate its potential Silicosis was induced via intratracheal instillation of crystalline silica particles, with honokiol administered intraperitoneally for 14 days. Silica-induced confirmed, SIRT3 knockout overexpression lines were generated. Various analyses conducted, including immunoblotting, qRT-PCR, histology, transmission electron microscopy. Statistical significance determined using one-way ANOVA Tukey's post-hoc test. This elucidates how induces senescence, emphasizing mtDNA damage. Notably, (HKL) emerges as promising anti-senescence anti-fibrosis agent, acting through sirt3. effectively attenuated cells, dependent on sirt3 expression, while mitigating Sirt3, class III histone deacetylase, regulates mitochondrial stress. HKL activates sirt3, protecting against pulmonary fibrosis Additionally, downregulated cGAS expression senescent silica, suggesting sirt3's an upstream regulator cGAS/STING signaling pathway. Moreover, treatment inhibited activation NF-κB pathway, associated reduced oxidative stress enhanced activity SOD2, function, sirt3-mediated deacetylation. promoted deacetylation further safeguarding integrity. uncovers natural compound, HKL, anti-fibrotic properties activating shedding light pathogenesis avenues.
Language: Английский
Citations
11