Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 6003 - 6021
Published: Dec. 1, 2023
The
maintenance
of
bone
homeostasis
is
dynamically
regulated
by
osteoblast-mediated
formation
and
osteoclast-mediated
resorption.
Abnormal
differentiation
osteoclast
insufficient
osteoblast
production
can
cause
diseases
such
as
osteoporosis.
As
one
the
highly
conserved
catabolic
pathways
in
eukaryotic
cells,
autophagy
plays
an
important
role
maintaining
cell
homeostasis,
stress
injury
repair,
proliferation
differentiation.
Numerous
studies
have
found
that
activity
essential
for
survival,
function
regulation
affect
metabolism
osteoblasts
osteoclasts,
thus
affecting
homeostasis.
Therefore,
using
a
theme,
this
review
outlines
basic
process
autophagy,
relationship
between
summarizes
latest
research
progress
common
autophagic
signaling
osteoclasts.
regulatory
effects
protein
molecules
natural
compounds
on
pathway
osteoclasts
discovered
current
are
summarized
discussed.
This
will
help
to
further
clarify
mechanism
osteoporosis,
understand
propose
new
therapeutic
strategies
ideas
anti-osteoporosis.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 114706 - 114706
Published: July 1, 2023
Acute
myocardial
infarction
remains
the
leading
cause
of
death
in
humans.
Timely
restoration
blood
perfusion
to
ischemic
myocardium
most
effective
strategy
treatment
acute
infarction,
which
can
significantly
reduce
morbidity
and
mortality.
However,
after
flow
reperfusion,
injury
will
aggravate
induce
apoptosis
cardiomyocytes,
a
process
called
ischemia-reperfusion
injury.
Studies
have
shown
that
loss
cardiomyocytes
caused
by
oxidative
stress,
iron
load,
increased
lipid
peroxidation,
inflammation
mitochondrial
dysfunction,
etc.,
are
involved
In
recent
years,
with
in-depth
research
on
pathology
injury,
people
gradually
realized
there
is
new
form
cell
pathological
namely
ferroptosis.
A
number
studies
found
tissue
patients
changes
closely
related
ferroptosis,
such
as
metabolism
disorder,
reactive
oxygen
species
free
radicals.
Natural
plant
products
resveratrol,
baicalin,
cyanidin-3-O-glucoside,
naringenin,
astragaloside
IV
also
exert
therapeutic
effects
correcting
imbalance
these
ferroptosis-related
factors
expression
levels.
Combining
our
previous
studies,
this
review
summarizes
regulatory
mechanism
natural
intervening
ferroptosis
order
provide
reference
information
for
development
targeted
inhibitor
drugs
cardiovascular
diseases.
Nutrition & Metabolism,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: July 18, 2024
Abstract
Background
Natural
compounds
can
positively
impact
health,
and
various
studies
suggest
that
they
regulate
glucose‒lipid
metabolism
by
influencing
short-chain
fatty
acids
(SCFAs).
This
is
key
to
maintaining
energy
balance
normal
physiological
functions
in
the
body.
review
explores
how
SCFAs
glucose
lipid
natural
modulate
these
processes
through
SCFAs.
provides
a
healthier
approach
treating
disorders
future.
Methods
article
reviews
relevant
literature
on
glycolipid
from
PubMed
Web
of
Science
Core
Collection
(WoSCC).
It
also
highlights
range
compounds,
including
polysaccharides,
anthocyanins,
quercetins,
resveratrols,
carotenoids,
betaines,
modulation
SCFA
pathway.
Results
enrich
SCFA-producing
bacteria,
inhibit
harmful
operational
taxonomic
unit
(OTU)
abundance
intestinal
transport
rate
gut
microbiota
affect
content
intestine.
However,
most
have
been
conducted
animals,
lack
clinical
trials,
involve
fewer
target
More
research
needed
support
conclusions
develop
interventions.
Conclusions
are
crucial
for
human
health
produced
mainly
via
dietary
fiber
fermentation.
Eating
foods
rich
fruits,
vegetables,
tea,
coarse
foods,
hinder
bacterial
growth
promote
beneficial
proliferation,
thus
increasing
levels
regulating
metabolism.
By
investigating
pathway,
novel
insights
directions
glucolipid
be
provided.
Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
32(1), P. 101876 - 101876
Published: Nov. 16, 2023
Acute
inflammation
may
develop
into
chronic,
life-threatening
inflammation-related
diseases
if
left
untreated
or
there
are
persistent
triggering
factors.
Cancer,
diabetes
mellitus,
stroke,
cardiovascular
diseases,
and
neurodegenerative
disorders
some
of
the
affecting
millions
people
worldwide.
Despite
that,
conventional
medical
therapy
such
as
non-steroidal
anti-inflammatory
drugs
(NSAIDs)
is
associated
with
serious
adverse
effects;
hence,
an
urgent
need
for
a
newer
safer
therapeutic
alternative
from
natural
sources.
Iridoids
naturally
occurring
heterocyclic
monoterpenoids
commonly
found
in
Rubiaceae
plants.
Plant
extracts
family
were
demonstrated
to
have
medicinal
benefits
against
neurodegeneration,
inflammation,
oxidative
stress,
hyperglycaemia,
cancer.
However,
effects
iridoids
derived
well
their
prospective
impacts
on
vitro
vivo
not
been
thoroughly
explored.
The
databases
PubMed,
Scopus,
Web
Science
searched
pertinent
articles
accordance
PRISMA-ScR
guidelines.
A
total
31
studies
potentials
identified.
According
current
research,
genipin,
geniposide,
monotropein
most
researched
that
reduce
inflammation.
These
primarily
act
by
attenuating
inflammatory
cytokines
mediators
via
inhibition
NF-κB
signalling
pathway
various
disease
models.
comprehensive
overview
research
properties
presented
this
review,
highlighting
characteristics
experimental
models
used
mechanisms
action
these
iridoids.
To
agent
iridoids,
more
needed
elucidate
mechanism
wide
variety
clinical
pertaining
diseases.
Foods,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1668 - 1668
Published: April 17, 2023
For
many
centuries,
Gardenia
(Gardenia
jasminoides
Ellis)
was
highly
valued
as
a
food
homologous
Chinese
herbal
medicine
with
various
bioactive
compounds,
including
crocin
I
and
geniposide.
However,
the
functional
mechanism
underlying
hypoglycemic
effect
of
gardenia
is
absent
in
literature.
To
evaluate
its
different
extracts
on
type
2
diabetes
mellitus
(T2DM)
vivo
vitro
experiments,
dried
powder
extracted
using
60%
ethanol
eluted
at
concentrations
to
obtain
corresponding
purified
fragments.
After
that,
active
chemical
compositions
fragments
were
analyzed
HPLC.
Then,
effects
compared
experiments.
Finally,
characterized
UPLC-ESI-QTOF-MS/MS
mass
spectrometric
fragmentation
pathway
two
main
geniposide
I,
identified.
The
experimental
results
indicated
that
inhibitory
40%
EGJ
(crocin
I)
α-glucosidase
better
than
20%
(geniposide)
vitro.
T2DM
animal
presumed
potentially
mechanisms
between
T2DM.
This
research
demonstrated
hypoglycemia
from
not
only
one
target
but
provides
background
for
deep
processing
utilization.
Current Topics in Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
23(5), P. 371 - 388
Published: Dec. 26, 2022
Iridoids
are
secondary
plant
metabolites
that
multitarget
compounds
active
against
various
diseases.
structurally
classified
into
iridoid
glycosides
and
non-glycosidic
iridoids
according
to
the
presence
or
absence
of
intramolecular
glycosidic
bonds;
additionally,
can
be
further
subdivided
carbocyclic
secoiridoids.
These
monoterpenoids
belong
cyclopentan[c]-pyran
system,
which
has
a
wide
range
biological
activities,
including
antiviral,
anticancer,
antiplasmodial,
neuroprotective,
anti-thrombolytic,
antitrypanosomal,
antidiabetic,
hepatoprotective,
anti-oxidant,
antihyperlipidemic
anti-inflammatory
properties.
The
basic
chemical
structure
in
plants
(the
ring
scaffold)
is
biosynthesized
by
enzyme
synthase
using
8-oxogeranial
as
substrate.
With
advances
phytochemical
research,
many
with
novel
outstanding
activity
have
been
identified
recent
years.
Biologically
derivatives
found
variety
families,
Plantaginaceae,
Rubiaceae,
Verbenaceae,
Scrophulariaceae.
potential
modulating
events
This
review
highlights
includes
compilation
publications
on
pharmacology
iridoids.
Several
vitro
vivo
models
used,
along
results,
also
included
paper.
paper's
systematic
summary
was
created
searching
for
relevant
material
websites
such
Google
Scholar,
PubMed,
SciFinder
Science
Direct,
others.
will
provide
researchers
thorough
understanding
its
congeners,
help
designing
large
number
strong
impact
curing
