The roles of pyroptosis in genitourinary diseases DOI Creative Commons
Haopeng Liu, Haoran Liu,

Guoshuai Huang

et al.

International Urology and Nephrology, Journal Year: 2023, Volume and Issue: 56(5), P. 1515 - 1523

Published: Dec. 16, 2023

Abstract Pyroptosis, a form of programmed cell death distinct from apoptosis and necrosis, is thought to be closely associated with the pathogenesis diseases. Recently, association between pyroptosis urinary diseases has attracted considerable attention, comprehensive review focusing on this issue not available. In study, we reviewed role in development progression benign malignancies. Based this, been implicated summary, sheds light future research directions provides novel ideas for using as powerful tool fight

Language: Английский

NLRP3 Inflammasome: A central player in renal pathologies and nephropathy DOI

Nada T. Henedak,

Hanan S. El‐Abhar, Ayman A. Soubh

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122813 - 122813

Published: June 9, 2024

Language: Английский

Citations

10
New Insights into Baicalein’s Effect on Chlorpyrifos-Induced Liver Injury in Carp: Involving Macrophage Polarization and Pyropto sis DOI
Jing Liu, Wenyue Zhang, Xiaojing Li

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(9), P. 4132 - 4143

Published: Feb. 27, 2023

Chlorpyrifos (CPF) is widely used in agriculture, plants, and buildings to kill pests worms. Excessive environmental residues of CPF will result soil ecological contamination toxicity animals humans. Baicalein (Bai), derived from the root natural Scutellaria baicalensis, a potent anti-inflammatory, antioxidant, antitumor agent. The objective this paper investigate molecular mechanism by which Bai prevents CPF-induced hepatotoxic injury. Carp were kept water containing (23.2 μg/L) and/or fed diets (0.15 g/kg). We found that attenuated liver tissue damage vacuolization caused CPF. confirmed causes M1/M2 polarization imbalance macrophages hepatocyte pyroptosis, ultimately leads Further exploration internal shows participates destroying AMPK/SIRT1/pGC-1α pathway causing mitochondrial biogenesis dynamics imbalance. Notably, significantly inhibition pathway. In summary, our results suggest alleviates exposure-induced pathway, thereby attenuating macrophage M1 hyperpolarization pyroptosis inhibiting NF-κB These may provide new insights into detoxification on same type organophosphorus pesticides.

Language: Английский

Citations

20
Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death Through SENP1/SIRT3 Signaling Pathway Activation DOI
Peipei Zhang,

Haowei Wu,

Haifei Lou

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Diabetic heart damage can lead to cardiomyocyte death, which endangers human health. Baicalin (BAI) is a bioactive compound that plays an important role in cardiovascular diseases. Sentrin/SUMO-specific protease 1 (

Language: Английский

Citations

7
The Mechanism of Baicalin in the Treatment of Mycoplasma Pneumoniae Pneumonia by Regulating NLRP3/Caspase-1 Signaling Pathway DOI

Dan Song,

Wenfeng Wei,

Jie Zhang

et al.

Immunological Investigations, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Jan. 9, 2025

This study investigated the mechanism of baicalin (BIA) attenuating inflammatory response and lung injury in mycoplasma pneumoniae pneumonia (MPP) mice. MPP mouse models were established then treated with BIA, azithromycin, or NLRP3 inflammasome activator. Lung wet-to-dry weight (W/D) ratio weighed. Serum levels MP-IgM, C-reactive protein (CRP) bronchoalveolar lavage fluid (BALF) detected by kits, NLRP3/Caspase-1 pathway-related Western blot, IL-1β, IL-18, IL-6 TNF-α ELISA. HE staining was performed to detect injury. mice showed elevated W/D ratio, upregulated serum MP-IgM CRP BALF protein, enhanced levels, which reversed BIA azithromycin treatment, suggesting that attenuated pulmonary The tissue NLRP3, cleaved Caspase-1,Caspase-1, GSDMD-N GSDMD raised IL-1β IL-18 changes annulled inhibited pathway activation. activation partially abrogated alleviative effect on mitigates inhibiting

Language: Английский

Citations

1
Baicalin inhibits monosodium urate crystal‐induced pyroptosis in renal tubular epithelial cell line through Panx‐1/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments DOI

Wanting Fu,

Ziyuan Liu, Y. L. Wang

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(4)

Published: April 1, 2024

Abstract Pyroptosis is a programmed cell death process that frequently occurs in many diseases, including hyperuricemic nephropathy (HN). In HN, range of stimuli mediates inflammation, leading to the activation inflammasomes and production gasdermin D (GSDMD). Baicalin (BA), natural flavonoid renowned for its antioxidant anti‐inflammatory properties, was investigated role HN this study. Initially, HN‐like inflammation pyroptosis were induced HK‐2 cells with treatment monosodium urate (MSU), followed by BA treatment. The expression pyroptosis‐associated genes, Panx‐1 P2X7, at both mRNA protein levels assessed through real‐time polymerase chain reaction (RT‐qPCR) Western blotting (WB) without or results showed P2X7 increased MSU‐treated cells, which subsequently decreased upon Further experiments could combine NLRP3 inflammasome GSDMD, destabilizing GSDMD protein. Moreover, protected membrane from MSU‐induced damage, as evidenced Hoechst 33342 PI double staining, lactate dehydrogenase (LDH) assays, electron microscopy observations. These suggest involved regulating Panx‐1/P2X7 pathways thus inhibits pyroptosis, highlighting potential therapeutic effect HN.

Language: Английский

Citations

4
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca2+/ROS pathway in platelets to ameliorate inflammatory coagulopathy DOI

Peichun Wang,

Jiao Wu,

Qiongsen Wang

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 949, P. 175674 - 175674

Published: April 4, 2023

Language: Английский

Citations

9
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway DOI

Yaru Wang,

Jinyu Zhang,

Zhuo Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(37), P. 20496 - 20512

Published: Sept. 6, 2024

Acute kidney injury (AKI) is characterized by a sudden decline in renal function. The inflammatory response the fundamental pathologic alteration throughout AKI, regardless of various causal factors. Macrophages are main immune cells involved microenvironment AKI. Consequently, targeting macrophages might become novel strategy for treatment In this study, we demonstrated that pseudoginsenoside-F11 (PF11), distinctive component

Language: Английский

Citations

3
Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis DOI Creative Commons
Xiaoming Li, Rui‐Hua Xu, Dan Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Acute kidney injury (AKI) is a common critical clinical disease that linked to significant morbidity, recurrence, and mortality. It characterized by fast prolonged loss in renal function arising from numerous etiologies pathogenic pathways. Renal fibrosis, defined as the excessive accumulation of collagen proliferation fibroblasts within tissues, contributes structural damage functional decline kidneys, playing pivotal role advancement Chronic Kidney Disease (CKD). Until now, while continuous replacement therapy (CRRT) has been utilized management severe AKI, there remains dearth effective targeted therapies for AKI stemming diverse etiologies. Similarly, identification specific biomarkers pharmacological targets treatment fibrosis challenge. Baicalin, naturally occurring compound classified flavonoid group commonly found Chinese herb Scutellaria baicalensis, shown range characteristics, such antioxidant, anti-inflammatory, antifibrotic, antitumor antiviral effects, evidenced research studies. Research shows Baicalin potential treating diseases like fibrosis. This review aims summarize Baicalin’s progress these areas, including its molecular mechanism, application treatment, absorption, distribution, metabolism, excretion. therapeutic effects are achieved through various pathways, antifibrosis, regulation apoptosis cell proliferation. Besides, we also hope this may give some enlightenment practice.

Language: Английский

Citations

0
Bone Marrow Mesenchymal Stem Cell-Originated Exosomes Curb Oxidative Stress and Pyroptosis Triggered by Ovarian Ischemia/Reperfusion via the TXNIP/NLRP3 Inflammasome Pathway. DOI
Min Xu, M. Madugoda Ralalage Don, Yiyuan Chen

et al.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction DOI Creative Commons
Lujian Zhu,

Minli Hu,

Haoming Xu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes cytoplasmic endotoxins as part the immune defense. It specifically characterized Gasdermin-mediated pore formation leading to lysis, pyroptosis also entails release pro-inflammatory cytokines. As a natural mechanism system, it activates in response harmful stimuli eliminate threats and facilitate tissue repair. However, excessive can lead detrimental outcomes, such infectious shock, multiple organ dysfunction syndrome (MODS), increased susceptibility secondary infections. Sepsis, unchecked infection, remains cause MODS among critically ill patients. The pathogenesis sepsis complex multifaceted, innate inflammation that kills infected cells releases Recent research has increasingly explored link between sepsis, focusing on its mechanisms, roles, potential therapeutic targets. There been significant advancement understanding pyroptosis, highlighting vital role development sepsis. This review delves into molecular pathophysiological roles with particular emphasis impact specific organs heart, lungs, liver, kidney brain, aiming identify new diagnostic markers targets for management.

Language: Английский

Citations

0