The Cognitive Restoration Effects of Resveratrol: Insight Molecular through Behavioral Studies in Various Cognitive Impairment Models DOI Creative Commons
Yingrak Boondam,

Chaianan Saefoong,

Natjanan Niltup

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(11), P. 3334 - 3357

Published: Oct. 10, 2024

Cognition is essential for daily activities and progressively deteriorates with age due to various factors leading cognitive decline. This decline often begins memory impairment advances broader dysfunctions. Resveratrol (RES), a natural phenolic compound found in red wine, has garnered significant attention its potential prevent review aims synthesize the latest preclinical data on restorative effects of RES. We highlight RES from cellular mechanisms behavioral outcomes. Evidence models demonstrates that exerts neuroprotective through multiple mechanisms, including anti-inflammatory, antioxidative, anti-apoptotic, neurotrophic actions, all which contribute enhancement studies. Despite established role mitigating decline, our identifies critical gap studies regarding flexibility. Further research this domain recommended. Additionally, species-specific pharmacokinetic differences may account inconsistencies between clinical outcomes, particularly rats humans. propose formulations designed delay gut metabolism enterohepatic circulation could enhance translational Furthermore, long-term are needed determine optimal dose capable maximizing health benefits without raising toxicity during chronic use.

Language: Английский

Unveiling the interplay of AMPK/SIRT1/PGC-1α axis in brain health: Promising targets against aging and NDDs DOI
Pratik Shankar Rakshe, Bhaskar Jyoti Dutta, Shivani Chib

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102255 - 102255

Published: March 14, 2024

Language: Английский

Citations

26
Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation DOI Creative Commons
Clara Bartra, Yi Yuan, Kristijan Vuraić

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 177 - 177

Published: Jan. 31, 2024

Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol proinflammatory monomeric C-reactive protein (mCRP). mCRP increases risk AD after stroke and we previously demonstrated that intracerebral induces AD-like dementia mice. Here, used BV2 microglia treated for 24 h presence or absence resveratrol. Cells conditioned media were collected analysis. Lipopolysaccharide (LPS) has also been implicated progression so LPS was as resveratrol-sensitive reference agent. at concentration 50 µg/mL activated nitric oxide pathway NLRP3 inflammasome pathway. Furthermore, induced cyclooxygenase-2 release cytokines. effectively inhibited these changes increased expression antioxidant enzyme genes Cat Sod2. As central defense, hub Sirt1 Nfe2l2 nuclear translocation signal transducer NF-ĸB. Proinflammatory by primary mixed glial cultures protected This work provides mechanistic insight into preventing agents.

Language: Английский

Citations

22
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α DOI
Xiaojuan Su, Qiong Li,

Mingzhi Yang

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 380, P. 114899 - 114899

Published: July 24, 2024

Language: Английский

Citations

7
An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1α pathway DOI Creative Commons
Ru‐Meng Wei, Yueming Zhang, Kaixuan Zhang

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Background: Early life stress can cause cognitive impairment in aged offspring. Environmental enrichment (EE) is considered to be an effective non-pharmacological treatment for improving decline. The aim of this research was evaluate the effect EE, on offspring induced by maternal sleep deprivation (MSD) and underlying mechanisms involved investigate its potential value clinical practice. Methods: CD-1 damns were subjected or not during late gestation. Twenty-one days after birth, assigned standard EE cages. At 18 months-old, learning memory function mice evaluated using Morris water maze. hippocampal prefrontal cortical levels protein, gene, proinflammation cytokines, oxidative indicators examined Western blot, real-time polymerase chain reaction, enzyme linked immunosorbent assay, biochemical assays. Results: Offspring MSD group exhibited declined abilities compared with control animals. Moreover, Sirtuin1 (Sirt1), peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α), postsynaptic density protein-95, synaptophysin lower those cytokines higher group; meanwhile, superoxide dismutase content malondialdehyde reactive oxygen species contents lower. However, these deleterious changes ameliorated exposure EE. Conclusions: attenuates MSD-induced impairment, stress, neuroinflammation reverses reduction synaptic protein via Sirt1/PGC-1α pathway.

Language: Английский

Citations

6
Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice DOI Creative Commons
Daoyong Li,

Mingyu Bai,

Zhanpeng Guo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Introduction Spinal cord injury (SCI) leads to severe inflammation and neuronal damage, resulting in permanent loss of motor sensory functions. Zinc ions have shown potential modulating cellular survival, making them a promising therapeutic approach for SCI. This study investigates the mechanisms zinc ion treatment SCI, focusing on its effects inflammation. Methods We used transcriptomic analysis identify key pathways genes involved inflammatory response mouse model In vitro studies assessed impact inflammation, cell polarization, apoptosis. IKBα expression was evaluated as target ions, both cultured cells vivo . Results Transcriptomic revealed that modulate through IKBα, which inhibits NF-κB activity. , upregulated expression, reducing These results were confirmed SCI model, where also reduced death. Discussion Our findings highlight novel mechanism by regulate upregulating inhibiting activation. suggests applications other conditions, warranting further investigation into their clinical benefits.

Language: Английский

Citations

0
Pharmacological and Therapeutic Innovation to Mitigate Radiation-Induced Cognitive Decline (RICD) in Brain Tumor Patients DOI

Jemema Agnes Tripena Raj,

Janmay Shah,

Smita V. Ghanekar

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217700 - 217700

Published: April 1, 2025

Language: Английский

Citations

0
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective DOI Creative Commons

Yueyue Guan,

Lei Li, Ruifu Yang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 23, 2025

Language: Английский

Citations

0
Chemotherapy-Mediated Neuronal Aberration DOI Creative Commons
Pradip Kumar Jaiswara, Surendra K. Shukla

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1165 - 1165

Published: Aug. 16, 2023

Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains first-line therapy most Along with its anti-cancerous effect, exhibits detrimental consequences that restrict efficacy and long-term utilization. Moreover, it effectively hampers quality life Cancer patients receiving chemotherapeutic drugs suffer from neurological dysfunction, referred to chemobrain, includes cognitive memory dysfunction deficits in learning, reasoning, concentration ability. neurotoxicity by damaging DNA neurons interfering repair system antioxidant machinery. In addition, also provokes inflammation inducing release various pro-inflammatory cytokines, including NF-kB, IL-1β, IL-6, TNF-α. The chemotherapy-mediated contributes chemobrain These inflammatory cytokines modulate growth signaling pathways reactive oxygen species homeostasis leading systemic body. This review an effort summarize available information which discusses role chemotherapy-induced how impacts different aspects outcome overall patient. Further, this article potential herbal-based remedies overcome neuronal toxicity well improve

Language: Английский

Citations

9
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence DOI Open Access
В. Э. Цейликман,

Olga B. Tseilikman,

Oleg N. Yegorov

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2856 - 2856

Published: Aug. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Language: Английский

Citations

3
Chemotherapy-induced cognitive impairment and glia: A new take on chemobrain? DOI Creative Commons

Maria Barbosa-Azevedo,

Ana Dias-Carvalho, Félix Carvalho

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 492, P. 117085 - 117085

Published: Sept. 3, 2024

The significant rise in cancer survivorship stands out as one of the most notable achievements modern science. However, this comes with a burden, treatment is not without adverse effects. Lately, there has been growing focus on cognitive dysfunction associated treatment, often referred to 'chemobrain'. It significantly impacts quality life for survivors. underlying mechanisms studied so far usually neurons, while other cells central nervous system are overlooked. This review seeks place hypothesis that glial may play role development chemotherapy-induced dysfunction. summarizes primary proposed date underscoring existing gaps research field. Inflammation and release pro-inflammatory mediators by M1 microglia A1 astrocytes prevalent finding after chemotherapy. activation some chemotherapeutic agents contribute neuronal degeneration, alterations synaptic branches, well glutamate excitotoxicity, which can impairment. reduction number oligodendrocytes chemotherapy also impact myelin sheath, contributing Furthermore, drugs activate microglia, decreased neuroplasticity and, possibly, In conclusion, data regarding effects scarce, it essential understand how these affected enable reliable therapeutic or preventive actions cancer-treated patients.

Language: Английский

Citations

3