Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers DOI Creative Commons
Oscar Salvador Barrera-Vázquez,

Juan Luis Escobar-Ramírez,

Gil Alfonso Magos-Guerrero

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1519 - 1540

Published: Oct. 15, 2024

Chronic venous disease (CVD) is a prevalent condition in adults, significantly affecting the global elderly population, with higher incidence women than men. The modulation of gene expression through microRNA (miRNA) partly regulated development cardiovascular (CVD). Previous research identified functional analysis seven genes (CDS2, HDAC5, PPP6R2, PRRC2B, TBC1D22A, WNK1, and PABPC3) as targets miRNAs related to CVD. In this context, emerge essential candidates for CVD diagnosis, representing novel molecular biological knowledge. This work aims identify, by network analysis, involved potential biomarkers, either interacting small molecules such toxins pollutants or searching new drugs. Our study shows an updated landscape signaling pathways involving pathology. latest includes data found experimental tests uses predictions propose both biomarkers develop diagnostic therapeutic methods early detection clinical setting. addition, our pharmacological has, first time, shown how use these find that may regulate them. Between research, toxins, pollutants, drugs showed outstanding interactions miRNAs. One them, hesperidin, widely prescribed drug treating modulating associated CVD, was used reference interact Among exhibit same miRNA profile include desoximetasone, curcumin, flurandrenolide, trifluridine, fludrocortisone, diflorasone, gemcitabine, floxuridine, reversine. Further investigation improve treatment disease. Additionally, supporting diagnosing predicting crucial.

Language: Английский

Curcumin mitigates heatstroke-induced myocardial injury by modulating the Akt/Bad/Caspase-3 pathway DOI

Yizhan Wu,

Fei Guo,

Ya Liu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151653 - 151653

Published: March 1, 2025

Language: Английский

Citations

1
Maternal Polyphenols and Offspring Cardiovascular–Kidney–Metabolic Health DOI Open Access
You‐Lin Tain, Chien‐Ning Hsu

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3168 - 3168

Published: Sept. 19, 2024

The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to recognition cardiovascular-kidney-metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, group phytochemicals, have demonstrated potential health-promoting effects. This review highlights impact maternal polyphenol supplementation on CKM offspring. Initially, we summarize interconnections between polyphenols each aspect syndrome. We then discuss in vivo studies that investigated use during pregnancy breastfeeding, focusing their role preventing syndrome Additionally, explore common mechanisms underlying protective effects supplementation. Overall, this underscores early-life interventions safeguarding against It emphasizes importance continued research advance our understanding facilitate clinical translation these interventions.

Language: Английский

Citations

6
Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases DOI Creative Commons
Qing Sun,

Mei Lv,

Yuhui Li

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106476 - 106476

Published: Sept. 21, 2024

Language: Английский

Citations

4
The Inflammation‐Initiating and Resolving Mechanisms and Oxidation: Could Periodontal Therapy and Nutritional Strategy Improve the Systemic Health? A Narrative Review DOI Creative Commons
Roberta Salvatori, Luigi Generali, Elisa Bellei

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Periodontitis (PDS) is one of the most common and crippling systemic diseases. It a chronic inflammatory condition that leads to loss periodontal attachment, resulting in tooth loss. In addition its effects on oral health nutrition, PDS closely linked other conditions such as diabetes mellitus (DM), cardiovascular diseases (CVD), rheumatoid arthritis (RA). The active role inflammation oxidation health, well their relationship with therapy, has been investigated. This review explores evidence how therapy dietary lifestyle can help reduce inflammation, limit oxidation, prevent related pathologies. Nonsurgical (NSPT) nutrition have extensively discussed potential contributors positive clinical outcomes by resolving pathogenic pathways. NSPT, foods, supplements represent therapeutic strategies address underlying mechanisms at various stages. A key finding from this treatment, conjunction nutritional counseling, improve PDS, DM, CVD, RA. However, for composition be effective, they should integrated into sustainable, long‐term lifestyle.

Language: Английский

Citations

0
Curcumin ameliorates aging-induced blood-testis barrier disruption by regulating AMPK/mTOR mediated autophagy DOI Creative Commons
Xue Chen, Zhenxing Yan,

Wenjing Cheng

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321752 - e0321752

Published: April 24, 2025

The blood-testis barrier (BTB) is composed of tight junctions (TJ) between adjacent Sertoli cells (SCs) and crucial for sperm growth development. Aging-induced TJ impairment closely related to testicular dysfunction. Curcumin, a natural compound, has been widely demonstrated have wide range pharmacological activities, but its regulatory effects on junction damage in the testis remain unclear. We here explored effect curcumin function underlying molecular mechanism by using D-galactose (D-gal)-induced mouse SCs (TM4) aging models vitro . In this study, D-gal increased expression aging-related proteins p16 p21, whereas significantly decreased (ZO-1, Claudin-4, Claudin-7, Occludin). addition, restored adverse SCs. Autophagy degradation system maintaining cell renewal homeostasis. autophagy level, D-gal. Using chloroquine (CQ), an inhibitor autophagy, rapamycin (RAPA), activator it was that plays key role amelioration injury Further studies unveiled activation mediated through AMPK/mTOR pathway. conclusion, ameliorates aging-induced signaling pathway-regulated autophagy. This study thus clearly identifies novel action treatment age-related male reproductive disorders.

Language: Английский

Citations

0
Engineered Prussian Blue‐Curcumin Nanozyme with RONS Scavenging Properties for Augmented Reversible Treatment of Cardiac Hypertrophy DOI
Anlin Luo, Jing Yuan Tan,

Haisong Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Pathological cardiac hypertrophy, often triggered by the excessive production and accumulation of reactive oxygen nitrogen species (RONS), may ultimately lead to heart failure. The treatment myocardial hypertrophy involves antioxidant stress therapy. In this study, coordinating curcumin with ferric ions during synthesis Prussian blue nanoparticles, a blue‐curcumin (PB‐Cur) nanozyme is successfully engineered exceptional (RONS) elimination capabilities. Following PVP modification, PB‐Cur exhibited favorable biocompatibility stability in aqueous solutions. Furthermore, shows remarkable reversible efficacy against both vitro vivo models. After one week treatment, group transverse aortic constriction (TAC)‐induced models displayed notable decrease fibrosis. Echocardiographic findings also revealed substantial improvement function among TAC mice following administration. Mechanistically, through (ROS) elimination, effectively downregulated oxidative stress‐related pathways, including MAPK PI3K‐Akt, which hold promise for treating diseases.

Language: Английский

Citations

0
The beneficial impact of curcumin on cardiac lipotoxicity DOI
Sajad Abolfazli, Alexandra E. Butler, Prashant Kesharwani

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: 76(10), P. 1269 - 1283

Published: Aug. 24, 2024

Abstract Lipotoxicity is defined as a prolonged metabolic imbalance of lipids that results in ectopic fat distribution peripheral organs such the liver, heart, and kidney. The harmful consequences excessive lipid accumulation cardiomyocytes cause cardiac lipotoxicity, which alters structure function heart. Obesity diabetes are linked to lipotoxic cardiomyopathy. These anomalies might be caused by shift accumulates toxic shifts glucose oxidation less fatty acid oxidation. Research has acids, acyl coenzyme A, diacylglycerol, ceramide stress cells. This can brought on apoptosis, impaired insulin signaling, endoplasmic reticulum stress, protein kinase C activation, p38 Ras-mitogen-activated (MAPK) or modification peroxisome proliferator–activated receptors (PPARs) family members. Curcuma longa used extract curcumin, hydrophobic polyphenol derivative with variety pharmacological characteristics. Throughout years, curcumin been utilized an anti-inflammatory, antioxidant, anticancer, hepatoprotective, cardioprotective, anti-diabetic, anti-obesity drug. Curcumin reduces lipotoxicity inhibiting apoptosis decreasing expression apoptosis-related proteins, reducing inflammatory cytokines, activating autophagy signaling pathway, marker proteins.

Language: Английский

Citations

3
Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders DOI Creative Commons

Maojun Cheng,

Fang Ding, Liyang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Lipid metabolism plays a crucial role in maintaining homeostasis and overall health, as lipids are essential molecules involved bioenergetic processes. An increasing body of research indicates that disorders lipid can contribute to the development progression various diseases, including hyperlipidemia, obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus, atherosclerosis, cancer, potentially leading poor prognoses. The activation oxidative stress pathway disrupts induces cellular stress, significantly contributing metabolic disorders. A well-documented crosstalk interconnection between these exists. Consequently, researchers have sought identify antioxidant-rich substances readily accessible everyday foods for potential use complementary therapies. Curcumin, known its anti-inflammatory antioxidant properties, has been shown enhance activity, mitigate alleviate by reducing reactive oxygen species (ROS) accumulation. These effects include decreasing fat deposition, acid uptake, improving insulin sensitivity. review existing literature reveals numerous studies emphasizing curcumin prevention management diseases. Curcumin influences through multiple mechanisms action, with playing central Thus, we aimed elucidate unified mechanism offering new insights into treatment Firstly, this article provides brief overview basic pathophysiological processes metabolism, well pathogenesis Notably, reviews mitigating preventing treating diseases associated disorders, diabetes, thereby highlighting therapeutic metabolism-related

Language: Английский

Citations

0
CARDIOPROTECTIVE EFFECTS OF CURCUMA LONGA L DOI
О. М. Бiловол, I. I. Kniazkova, V.М. Mishchenko

et al.

World of Medicine and Biology, Journal Year: 2025, Volume and Issue: 21(91), P. 220 - 220

Published: Jan. 1, 2025

Language: Английский

Citations

0
Resveratrol and Curcumin: Extending the Frontier of Phytomedicine DOI

Tracey Lynn Harney

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

The health of the oral cavity is a starting point for overall health, and systemic inflammation can arise when compromised, leading to an increased risk developing cardiovascular, metabolic, autoimmune, neurodegenerative disease or cancer. Fortunately, nature has provided us with bioactive molecules like polyphenols, such as curcumin resveratrol, which have demonstrated capacity immunomodulation, regeneration, repair. One challenges biomedical scientific community that delayed actualization full potential phytochemicals resveratrol potent therapeutic agents fact they display low bioavailability, instability, rapid clearance, making them unsuitable medicines by modern pharmacological standards. Thankfully, application nanotechnological design viable solution poor profile their clinical translation feasible emergence in near future.

Language: Английский

Citations

0