Low-Dose Dexmedetomidine Attenuates the Dose Requirement of Propofol for Suppression of Body Movement in Patients Undergoing Operative Hysteroscopy

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1185 - 1193

Published: Feb. 1, 2025

Dexmedetomidine is a central α-2 adrenergic agonist characterized by its sedative, analgesic, and sympatholytic properties. We investigated the effect of low dose dexmedetomidine on dose-response relationship propofol for sedation in patients undergoing operative hysteroscopy. The were firstly randomly assigned to receive either fentanyl (P group, n = 100) or combination propofol, dexmedetomidine, (DP 100). Subsequently, participants further randomized at doses 1.0, 1.5, 2.0, 2.5 mg/kg P 0.5, 2.0 DP group. primary outcome this study was incidence achieving effective dose, defined as dosage which patient exhibited no body movement during cervical dilation had BIS value below60. Probit method used calculate ED50 ED95 inhibition reaction hysteroscopic surgery. values surgery 1.781 (95% CI 1.507~2.118) 4.670 3.555~7.506) mg/kg, respectively, group; while these found be 0.983 0.800~1.173) 2.578 2.013~3.895) mg/kg. Low-dose (0.5μg/kg) could reduce requirement suppression

Language: Английский

Comparison of intratracheal intubation or not during endoscopic retrograde cholangiopancreatography: a meta-analysis and systematic review

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 15, 2025

In endoscopic retrograde cholangiopancreatography anesthesia, both intubation and non-intubation techniques have their own advantages disadvantages. However, whether either approach is associated with postoperative anesthesia-related adverse events remains controversial. We searched the literature in PubMed, Web of Science, Cochrane Library, Scopus, Ovid Embase databases up to October 2024. All studies comparing intubated vs. anesthesia for were included. The main outcome measures sedation-related death. Data combined using risk ratio 95% confidence intervals. study protocol was prospectively registered PROSPERO (CRD42024608807). finally included 8 a total 21,433 patients. Endotracheal lower (RR: 2.85, CI 1.33-6.09, p = 0.007). risks death 0.59, 0.36-0.96, 0.03) intraoperative hypotension 0.43, 0.26-0.69, 0.0006) without intubation. trial-sequence analysis, monitoring boundary crossed, indicating conclusive evidence statistically significant effect. Our findings suggest that endotracheal during but higher mortality compared non-intubation. these associations do not establish direct causality should be interpreted caution. Further high-quality randomized controlled trials are needed validate findings. Clinicians adopt patient-centered approach, carefully balancing potential benefits optimize airway management strategies cholangiopancreatography.

Language: Английский