State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review DOI Creative Commons
Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, I. Dumas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2829 - 2829

Published: Dec. 13, 2024

Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types TC, which complicates diagnosis and treatment. The presented review gathers current information on specific taking into account effects COVID-19 pandemic. It is likely that has influenced continues influence function thyroid gland. A high percentage patients with showing simultaneous pathological changes in suggests SARS-CoV-2 may disrupt this gland pro-oxidative mechanisms, inflammatory states, autoimmune diseases, thereby promoting formation neoplastic changes. Furthermore, expression ACE2, TMPRSS2, CLEC4M DPP4 genes, observed also occur COVID-19. Therefore, it probable interaction cell receptors Additionally, some drugs used TC therapy (e.g., levothyroxine) increase affinity for cells, could contribute more severe course emergence long-term symptoms (post-COVID-19). Moreover, consequences sanitary restrictions (limited access medical services, reduction endocrinological oncological procedures) took place many countries during pandemic lead future an increased number missed diagnoses aggressive cancers.

Language: Английский

Early-Life Antibiotic Exposures: Paving the Pathway for Dysbiosis-Induced Disorders DOI
Ali Attiq

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177298 - 177298

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 11, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 17, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 19, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0
Exploring Serum and Glucocorticoid-Regulated Kinase 1: A Promising Target for COVID-19 and Atrial Fibrillation Treatment DOI Creative Commons

J. Fatima,

Faez Iqbal Khan, Jamal e Fatima

et al.

Heart Rhythm O2, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Possible effect of E-SELECTIN (Ser128Arg), L-SELECTIN (Pro213Ser), P-SELECTIN (Thr715Pro) gene polymorphisms for COVID-19 disease severity DOI
Nihan Bozkurt, Figen Güzelgül, Nejmiye Akkuş

et al.

Frontiers in Life Sciences and Related Technologies, Journal Year: 2025, Volume and Issue: 6(1), P. 21 - 27

Published: April 30, 2025

COVID-19 is an inflammatory disease characterized by a severe immune response, the pathogenesis of which mediated many cytokines. It was determined that cytokine storm occurs during infection may trigger coagulopathy disrupting interaction between platelets, endothelium, and leukocytes. Selectins (P-SELECTIN, L-SELECTIN, E-SELECTIN) are active in mammalian system, especially tissues. They important adhesion molecules play part formation response healing process. In this study, probable effects P-SELECTIN, E-SELECTIN gene variations on (on severity course disease) were investigated. direction, 44 controls 129 patients (45 mild symptoms, 30 ward patients, 54 intensive care patients) included study. Genotyping selectin polymorphisms performed PCR-Restriction Fragment-Length Polymorphism (RFLP) techniques. E-SELECTIN, CC genotype C allele frequency higher inpatients than control group. The AA group (p = 0.0001). No significant relationship detected with P-SELECTIN L-SELECTIN polymorphisms. addition, binary distribution loci studied our study groups also examined. Statistically differences P-SELECTIN/E-SELECTIN E-SELECTIN/L-SELECTIN genotypes. Therefore, it concluded genotypes affect or disease.

Language: Английский

Citations

0
State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review DOI Creative Commons
Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, I. Dumas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2829 - 2829

Published: Dec. 13, 2024

Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types TC, which complicates diagnosis and treatment. The presented review gathers current information on specific taking into account effects COVID-19 pandemic. It is likely that has influenced continues influence function thyroid gland. A high percentage patients with showing simultaneous pathological changes in suggests SARS-CoV-2 may disrupt this gland pro-oxidative mechanisms, inflammatory states, autoimmune diseases, thereby promoting formation neoplastic changes. Furthermore, expression ACE2, TMPRSS2, CLEC4M DPP4 genes, observed also occur COVID-19. Therefore, it probable interaction cell receptors Additionally, some drugs used TC therapy (e.g., levothyroxine) increase affinity for cells, could contribute more severe course emergence long-term symptoms (post-COVID-19). Moreover, consequences sanitary restrictions (limited access medical services, reduction endocrinological oncological procedures) took place many countries during pandemic lead future an increased number missed diagnoses aggressive cancers.

Language: Английский

Citations

0