Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration DOI Creative Commons

Yifei Zheng,

Jiahui Yang,

Xuanyao Li

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106862 - 106862

Published: March 1, 2025

Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation cell death. Maintaining mitochondrial quality control is critical for preserving health ensuring function. Given their high demands, neurons depend on effective to sustain functionality. Neuronal senescence, characterized by progressive decline structural integrity function, hallmark neurodegenerative diseases. In senescent neurons, abnormal morphology, functional impairments, increased reactive oxygen species production disrupted mechanisms are frequently observed. Understanding the pathological changes neuronal structure, exploring intricate relationship between health, leveraging interventions provide promising foundation addressing age-related This review highlights key control, biogenesis, dynamics, ubiquitin-proteasome system, autophagy pathways, mitochondria-derived vesicles, inter-organelle communication, while discussing roles senescence potential therapeutic strategies. These insights may pave way innovative treatments mitigate disorders.

Language: Английский

Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration DOI Creative Commons

Yifei Zheng,

Jiahui Yang,

Xuanyao Li

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106862 - 106862

Published: March 1, 2025

Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation cell death. Maintaining mitochondrial quality control is critical for preserving health ensuring function. Given their high demands, neurons depend on effective to sustain functionality. Neuronal senescence, characterized by progressive decline structural integrity function, hallmark neurodegenerative diseases. In senescent neurons, abnormal morphology, functional impairments, increased reactive oxygen species production disrupted mechanisms are frequently observed. Understanding the pathological changes neuronal structure, exploring intricate relationship between health, leveraging interventions provide promising foundation addressing age-related This review highlights key control, biogenesis, dynamics, ubiquitin-proteasome system, autophagy pathways, mitochondria-derived vesicles, inter-organelle communication, while discussing roles senescence potential therapeutic strategies. These insights may pave way innovative treatments mitigate disorders.

Language: Английский

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