The role of the NLRP3 inflammasome in the pathogenesis of asthma: inflammatory mechanisms and emerging therapeutic strategies DOI Open Access
И. Х. Борукаева,

Kemran G. Edilov,

Alina S. Dzueva

et al.

Kazan medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

This article focuses on the pathophysiological mechanisms and therapeutic potential in management of bronchial asthma, a global health challenge with increasing prevalence. The pathogenesis asthma is rooted immune-mediated inflammation involving formation inflammasomes, molecular complexes that regulate inflammatory responses. Inflammasomes, particularly NLRP3, play pivotal role disease development by interacting allergens initiating signaling cascades lead to production pro-inflammatory cytokines such as interleukin-1β (IL-1β) Interleukin-18. These recruit immune cells, including mast eosinophils, T-lymphocytes, which contribute airway inflammation, hyperreactivity, obstruction. examines phenotypes, infection-dependent atopic well association between NLRP3 inflammasome activation impaired lung function, steroid resistance, neutrophilic inflammation. Special attention given cellular involved process, interaction T-helper macrophages, leading release histamine, heparin, lysosomal enzymes, reactive oxygen species, nitric oxide, prostaglandins, leukotrienes. Inflammatory mediators IL-4, IL-5, IL-13 remodeling, mucus hypersecretion, spasm. Furthermore, can disrupt epithelial barrier exacerbating allergic study highlights chronic changes tree caused prolonged It emphasizes importance regulation, use selective inhibitor MCC950, effectively reduces demonstrates promising for asthma. concludes underscoring integrating research into clinical practice, suggesting targeted therapy, could transform treatment. need shift toward personalized medicine managing diseases like

Language: Английский

The role of the NLRP3 inflammasome in the pathogenesis of asthma: inflammatory mechanisms and emerging therapeutic strategies DOI Open Access
И. Х. Борукаева,

Kemran G. Edilov,

Alina S. Dzueva

et al.

Kazan medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

This article focuses on the pathophysiological mechanisms and therapeutic potential in management of bronchial asthma, a global health challenge with increasing prevalence. The pathogenesis asthma is rooted immune-mediated inflammation involving formation inflammasomes, molecular complexes that regulate inflammatory responses. Inflammasomes, particularly NLRP3, play pivotal role disease development by interacting allergens initiating signaling cascades lead to production pro-inflammatory cytokines such as interleukin-1β (IL-1β) Interleukin-18. These recruit immune cells, including mast eosinophils, T-lymphocytes, which contribute airway inflammation, hyperreactivity, obstruction. examines phenotypes, infection-dependent atopic well association between NLRP3 inflammasome activation impaired lung function, steroid resistance, neutrophilic inflammation. Special attention given cellular involved process, interaction T-helper macrophages, leading release histamine, heparin, lysosomal enzymes, reactive oxygen species, nitric oxide, prostaglandins, leukotrienes. Inflammatory mediators IL-4, IL-5, IL-13 remodeling, mucus hypersecretion, spasm. Furthermore, can disrupt epithelial barrier exacerbating allergic study highlights chronic changes tree caused prolonged It emphasizes importance regulation, use selective inhibitor MCC950, effectively reduces demonstrates promising for asthma. concludes underscoring integrating research into clinical practice, suggesting targeted therapy, could transform treatment. need shift toward personalized medicine managing diseases like

Language: Английский

Citations

0