Assessment of glycemic control and correlation of HbA1c level with lipid profile and duration of diabetes in type 2 diabetes mellitus patients DOI Open Access
Birendra Kumar Jha, Raman Mishra, Jitendra Kumar Singh

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 12(02), P. 13 - 24

Published: Aug. 27, 2024

Background & Objectives: The prevalence of Type 2 diabetes mellitus, or DM, is rising globally. A periodic estimation HbA1c has been recommended to track the state glycemic control DM patients, in order associated disorders. main consequence and cause death identified as cardiovascular disease (CVD).Optimization status along with decreasing CVD risk factors are critical preventing morbidity mortality patients DM. Since there a lack data on these factors, Madhesh Province, Nepal, we aimed evaluate status, estimate lipid profile, ascertain their correlation, including duration among tertiary care hospitals Nepal. Materials Methods: hospital based cross-sectional study was conducted 139 In gather information participants, systematic questionnaire introduced. physical clinical examination performed, an appropriate volume blood drawn prior written consent. profile parameters, HbA1C, Fasting post prandial serum glucose were estimated. Results: 84 (60.3%) 106 (76.3%) cases, increased fasting postprandial sugar. mean±SD level 8.40±0.8%. More than half (52.5%) had poor control, while 22.3% inadequate reference >8% 7 8%, respectively. substantial LDL-C, triglycerides total cholesterol observed 122 85.6% reduced HDL-C. significant strong positive association found between triglycerides, contrast, no discernible observed. Conclusion: Glycemic inadequate. Triglycerides significantly positively correlated HbA1c, but not HDL-C, course diabetes.

Language: Английский

A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity DOI Creative Commons
Mahmood Safaei, Elankovan Sundararajan, Maha Driss

et al.

Computers in Biology and Medicine, Journal Year: 2021, Volume and Issue: 136, P. 104754 - 104754

Published: Aug. 16, 2021

Obesity is considered a principal public health concern and ranked as the fifth foremost reason for death globally. Overweight obesity are one of main lifestyle illnesses that leads to further concerns contributes numerous chronic diseases, including cancers, diabetes, metabolic syndrome, cardiovascular diseases. The World Health Organization also predicted 30% in world will be initiated with diseases 2030 can stopped through suitable identification addressing associated risk factors behavioral involvement policies. Thus, detecting diagnosing early possible crucial. Therefore, machine learning approach promising solution predictions overweight because it offer quick, immediate, accurate condition likelihoods. present study conducted systematic literature review examine research techniques prevention treatment from 2010 2020. Accordingly, 93 papers identified articles primary studies an initial pool over 700 obesity. Consequently, this initially recognized significant potential influence cause adult Next, consequences investigated. Ultimately, methods used prediction Finally, seeks support decision-makers looking understand impact on general population identify outcomes guide authorities mitigate threats effectively obese people

Language: Английский

Citations

440
The Interaction Between Age and Risk Factors for Diabetes and Prediabetes: A Community-Based Cross-Sectional Study DOI Creative Commons
Zihui Yan,

Mengjie Cai,

Xu Han

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 85 - 93

Published: Jan. 1, 2023

Objective: This study aimed to investigate the interaction between age groups and risk factors for diabetes prediabetes in Shanghai communities identify effect of on other prediabetes. Methods: recruited 3540 participants with undiagnosed or 14 from February August 2019. All underwent a comprehensive examination, including filling out detailed questionnaire, physical 75 g oral glucose tolerance test, blood sample collection. In addition, logistic regression was used analyze diabetes. Results: The statistical analysis included 2776 people. this study, prevalence were 15.1% 52.3%, respectively. is higher elderly than middle-aged group. Among diabetes, overweight associated ( P -interaction 0.028). among prediabetes, high level education 0.039) elevated serum cholesterol lower 0.019). Conclusion: confirmed an influencing factors, which may be important explaining differences populations. Community health facilities can provide guidance people different prevent control Keywords: age,

Language: Английский

Citations

58
Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP DOI Creative Commons
Pallavi Asthana, Hoi Leong Xavier Wong

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167081 - 167081

Published: Feb. 16, 2024

Language: Английский

Citations

6
The burden of prediabetes in low- and middle-income countries: a systematic review and meta-analysis DOI
Anjaly Joseph, Christian Sewor,

Bhagiaswari Kodapally

et al.

European Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease DOI
Mao‐Qiang Man, Joan S. Wakefield, Theodora M. Mauro

et al.

Journal of Diabetes, Journal Year: 2022, Volume and Issue: 14(9), P. 586 - 595

Published: Aug. 31, 2022

Abstract Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation pollution, epidermal itself can regulate cutaneous extracutaneous functions. The biophysical properties of the stratum corneum reflect status both systemic conditions. Type 2 diabetes in murine models humans displays alterations functions, reduced levels hydration increased permeability as well delayed barrier recovery, which all provoke exacerbate inflammation. Because inflammation plays a pathogenic role type diabetes, therapy that improves functions could be an alternative approach to mitigating its associated disorders.

Language: Английский

Citations

14
Identification of the risk factors of type 2 diabetes and its prediction using machine learning techniques DOI

Md. Merajul Islam,

Md. Jahanur Rahman,

Md. Menhazul Abedin

et al.

Health Systems, Journal Year: 2022, Volume and Issue: 12(2), P. 243 - 254

Published: Nov. 5, 2022

This study identified the risk factors for type 2 diabetes (T2D) and proposed a machine learning (ML) technique predicting T2D. The T2D were by multiple logistic regression (MLR) using p-value (p<0.05). Then, five ML-based techniques, including regression, naïve Bayes, J48, multilayer perceptron, random forest (RF) employed to predict utilized two publicly available datasets, derived from National Health Nutrition Examination Survey, 2009-2010 2011-2012. About 4922 respondents with 387 patients included in dataset, whereas 4936 373 six (age, education, marital status, SBP, smoking, BMI) nine race, DBP, direct cholesterol, physical activity, RF-based classifier obtained 95.9% accuracy, 95.7% sensitivity, 95.3% F-measure, 0.946 area under curve.

Language: Английский

Citations

8
Socioeconomic and ethnic inequalities increase the risk of type 2 diabetes: an analysis of NHS health check attendees in Birmingham DOI Creative Commons

Chung Him Au-Yeung,

David Ellis, Alexander Dallaway

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 27, 2024

Birmingham has a significantly higher type-II diabetes prevalence than the national average. This study aimed to investigate association of socioeconomic deprivation and ethnicity on risk in Birmingham.

Language: Английский

Citations

1
Partial Recovery of Telomere Length After Long-Term Virological Suppression in Persons Living with HIV DOI Creative Commons
Julen Cadiñanos, Javier Rodríguez-Centeno, Rocío Montejano

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(10)

Published: Sept. 23, 2024

Abstract Background People with HIV-1 (PWH) age differently than the general population. Blood telomere length (BTL) attrition is a surrogate biomarker of immunosenescence and aging in PWH. BTL reduced immediately after infection recovers PWH long-term virologic suppression, but extent this recovery unknown. Methods This prospective 6-year observational study assessed evolution who were virologically suppressed. A cross-sectional analysis additionally compared age- sex-matched blood donors persons older 60 years from population cohort. DNA whole was isolated, relative determined by monochrome quantitative multiplex polymerase chain reaction assay expressed as ratio to single-copy gene (T/S). Results total 128 included study. These same (median age, 55 years; 27.3% women) cross-sectionally at follow-up gender-matched years) individuals cohort 70 years). An inverse correlation between observed. The median shorter their matched (T/S, 1.07 [IQR, 0.95–1.17] vs 1.28 1.12–1.48]; P &lt; .001) longer elderly 0.89 0.77–0.98], .001). experienced increase 6 2.9% 1.04 1.07; = .002). In PWH, associated (coefficient, −0.007 45, SE 0.002 04, .002) baseline lower CD4 count gain −0.000 06, 0.000 02, .004). Shorter (odds ratio, 0.91 [95% CI, .87–.94]; higher glucose levels 1.02–1.07]; .003) greater similarity Conclusions suppression experience trend toward an increased follow-up. Middle-aged people controlled have expected for chronologic that 15

Language: Английский

Citations

1
Development and Validation of a Prediction Model for Survival in Diabetic Patients With Acute Kidney Injury DOI Creative Commons

Man-Qiu Mo,

Ling Pan,

Zichun Huang

et al.

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 22, 2021

We aimed to analyze the risk factors affecting all-cause mortality in diabetic patients with acute kidney injury (AKI) and develop validate a nomogram for predicting 90-day survival rate of patients.Clinical data AKI who were diagnosed at The First Affiliated Hospital Guangxi Medical University from April 30, 2011, 2021, collected. A total 1,042 randomly divided into development cohort validation ratio 7:3. primary study endpoint was death within 90 days diagnosis. Clinical parameters demographic characteristics analyzed using Cox regression prediction model AKI, then constructed. concordance index (C-index), receiver operating characteristic curve, calibration plot used evaluate model.The enrolled 730 median follow-up time 87 (40-98) days, 86 (11.8%) died during follow-up. 88.2% (644/730), recovery renal function survivors 32.9% (212/644). Multivariate analysis showed that advanced age (HR = 1.064, 95% CI 1.043-1.085), lower pulse pressure 0.964, 0.951-0.977), stage 3 4.803, 1.678-13.750), 25-hydroxyvitamin D3 0.944, 0.930-0.960), multiple organ dysfunction syndrome 2.056, 1.287-3.286) independent (all p < 0.01). C-indices 0.880 (95% 0.839-0.921) 0.798 0.720-0.876), respectively. excellent consistency between probability actual probability.We developed new has been internally verified have good discrimination, calibration, clinical value AKI.

Language: Английский

Citations

9
Germinated Rice Seeds Improved Resveratrol Production to Suppress Adipogenic and Inflammatory Molecules in 3T3-L1 Adipocytes DOI Creative Commons
Chaiwat Monmai, Jin-Suk Kim, So-Hyeon Baek

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5750 - 5750

Published: July 29, 2023

Obesity is a major risk factor for variety of diseases and contributes to chronic inflammation. Resveratrol naturally occurring antioxidant that can reduce adipogenesis. In this study, the antiadipogenic anti-inflammatory activities resveratrol-enriched rice were investigated in 3T3-L1 adipocyte cells. Cotreatment dexamethasone isobutylmethylxanthin upregulated adipogenic transcription factors signaling pathways. Subsequent treatment adipocytes with seed extracts suppressed differentiation by downregulating (peroxisome proliferator-activated receptor γ CCAAT/enhancer-binding protein α) pathways (extracellular signal-regulated kinase 1/2 B Akt), was especially observed cells treated germinated extract (DJ526_5). DJ526_5 also markedly reduced lipid accumulation expression genes. Lipopolysaccharide (LPS)-induced inflammatory cytokines (prostaglandin-endoperoxide synthase 2 (COX-2), tumor necrosis (TNF)-α, interleukin (IL)-1β, IL-6) decreased DJ526_5. Collectively, exerts effects suppressing adipogenesis factors. Moreover, ameliorates inhibiting activation phosphorylation NF-κB p65 ERK ½ (MAPK). These results highlight potential as an alternative obesity-reducing agent.

Language: Английский

Citations

3