Isolating the acute metabolic effects of carbohydrate restriction on postprandial metabolism with or without energy restriction: a crossover study

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: March 20, 2025

Abstract Low-carbohydrate diets and intermittent energy restriction may offer metabolic advantages in fuel utilisation, that are independent of weight loss. The underlying mechanisms for these effects unclear but involve extensions the catabolic phase and/or attenuation insulin secretion. To address this gap, we aimed to investigate acute effect carbohydrate at varying levels. Twelve, (six female) healthy overweight/obese participants (27.3 ± 1.8 years; 25.2 1.6 kg/m 2 ) completed three-way study. Volunteers followed three one day (36 h, covering intervention overnight fasting), separated by 5-day washout: a normal carbohydrate, energy-balanced diet (nEB, 55% CHO), low-carbohydrate, (LCEB, 50 g/day energy-restricted (LC25, CHO with 75% restriction). Fasting serial postprandial (360 min) measurements mixed test meal were collected following morning. Additionally, subjective appetite responses two-day subsequent ad libitum food intake was assessed. Both low-carbohydrate without induced comparable decrease triacylglycerol iAUC ( p = 0.02, 0.04, respectively), respiratory quotient (both < 0.01) along increase non-esterified fatty acids 3-hydroxybutyrate 0.001, 0.01, respectively) Compared non-restricted diet, glucose levels significantly increased LCEB arm 0.024) showed rising trend LC25 0.07). Neither nor resting, diet-induced thermogenesis altered variations or content. These findings demonstrate restriction, altering intake, can elicit similar those observed short-term fasting. As such propose strategy repeated cycles alone be an emerging alternative approach enhancement cardiometabolic health, warranting further investigation.

Language: Английский

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The Influence of Intermittent Fasting on Selected Human Anthropometric Parameters

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2630 - 2639

Published: Jan. 1, 2024

Intermittent fasting may be an effective tool for weight loss, but it is still unclear from previous studies to date whether as a continuous energy restriction in terms of reducing adipose tissue and leads unwanted muscle loss.

Language: Английский

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A Brief Web-Based and Mobile Intervention of Intermittent Fasting with Meal Support for Weight Loss Among Overweight Japanese Adults: A Pilot Study of a Randomized Controlled Trial. (Preprint)

Published: April 3, 2024

Intermittent fasting (IF) emerges as a promising dietary approach against obesity, which can be implemented feasible and cost-effective web-based strategy. We have developed Brief Online IF Program (OIF), features self-administered regimen supported with meals delivery, online guidance, app messages. This pilot study aimed to assess the effectiveness, feasibility, safety of OIF among overweight Japanese adults. Study design was 1:1 randomized controlled trial for 12 weeks. Overweight adults body mass index from 23 <35 were recruited in 1 university, hospital 2 company offices. For intervention group, meal replacements their weekly intermittent provided an guidance given via Zoom. They instructed fast by consuming read messages encouraging practices healthy lifestyles. The control group received only A non-blinded researcher administered interventions both groups. Primary outcome change weight assessed under intention-to-treat, primary analysis estimate between-group mean difference, adjusted sex, age, baseline weight. Secondary outcomes encompassed laboratory-based measures (body compositions, blood pressures, biomarkers such hemoglobin A1c, triglycerides, cholesterols), questionnaire-based (quality life, total physical activity, adherence intervention, adverse events, freely written feedback on interventions). 57 individuals enrolled, 28 allocated 29 group. At weeks, 25 participants 27 followed-up. Baseline median 75.8 kg 74.8 −0.9 (SD 1.9) 0.6 1.4) revealed significant difference −1.6 (95% CI −2.5 −0.8; P<.001) kg. However, no observed fat (mean −0.1 kg, 95% −1.3 1.4), but reduction muscle implied −0.2). Adherence 79% (22/28) 59% (17/29) No serious events reported. 12-week promote loss adults, may not result improvements composition. low dropout rate modest adherence, indicates feasibility program. future should conducted integration other components consistent mentoring exercise recommendations improve composition overall health outcomes. UMIN-CTR UMIN000050437

Language: Английский

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The effectiveness of mobile app usage in facilitating weight loss: An observational study

Obesity Science & Practice, Journal Year: 2024, Volume and Issue: 10(3)

Published: May 13, 2024

Abstract Aim With increasing rates of global obesity and associated health issues, there is an ever‐increasing need for weight management solutions to be more accessible. Mobile applications offer accessible support systems have the potential a viable effective solution as alternative traditional healthcare models. Objective To evaluate effectiveness SIMPLE mobile application time‐restricted eating in achieving loss (WL). Methods User data were analyzed between January 2021 2023. In‐app activity was calculated proportion active days over 12, 26 52 weeks. A day considered if it contains at least one in‐app action (e.g., logging weight, food, fasting, or physical activity). Users categorized into four levels: inactive (in‐app <33%), medium (33%–66%), high (66%–99%), maximal (100%). Weight change among groups assessed 26, Results Out 53,482 users, positive association found use app WL. Active users lost than their less counterparts. had median WL 4.20%, 5.04%, 3.86% weeks, respectively. larger percentage users—up 50.26%—achieved clinically significant (≥5%) when compared users. dose‐response relationship usage after adjusting gender, age, initial Body Mass Index; 10% increase correlated with increased by 0.43, 0.66 0.69 kg Conclusions The study demonstrates that enables directly level engagement. should supporting adults lose weight.

Language: Английский

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The Influence of the Energy Intake Variability During the Week on the Body Composition in an Adult Population

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(9), P. 1622 - 1628

Published: Jan. 1, 2024

The regularity of eating, together with other nutritional factors, is one the important determinants health. According to previous studies, it not clear if a greater fluctuation in energy intake associated higher body fat and weight gain, or people stable despite these fluctuations intake. aim study was verify variability each day week related amount anthropometric parameters.

Language: Английский

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Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases

Jurnal Penelitian Pendidikan IPA, Journal Year: 2023, Volume and Issue: 9(11), P. 1178 - 1188

Published: Nov. 25, 2023

The aging process is inherently linked to an increased susceptibility various chronic conditions, such as cardiovascular diseases, diabetes, and neurodegenerative disorders. aim of this research delves into the current body knowledge surrounding intermittent fasting its potential implications in preventing age-related diseases. methodological approach used systematic review. Research search using PRISMA strategy by searching journal articles from databases including Scopus, Proquest, Science Direct, CINAHL, Google Scholar last five years 2019 2023. results found 333 identified through contained methods screened titles. Result promising role promoting anti-aging effects age-associated diseases multifaceted influence on cellular molecular mechanisms. As innovative avenue, holds revolutionize strategies aimed at enhancing healthy longevity. new approaches anti for

Language: Английский

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