The efficacy of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters, metabolic factors, and quality of life in diabetic sarcopenia: a randomized controlled clinical trial

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 13, 2025

Abstract Aim To investigate the efficacy of Sarcomeal® sachet, as a protein supplement, plus vitamin D3 on muscle parameters, metabolic factors, and quality life (QoL) in individuals with diabetes sarcopenia. Methods Sixty were randomized into control or intervention group. The group received daily dose one Sarcomeal sachet 1000 IU D both groups recommended to consume protein-rich food, be educated about disease, perform physical activity for 12 weeks. Various assessments including blood tests, QoL conducted at beginning end trial. Results Over weeks, although had significant improvements mean skeletal mass index (SMI) (change: 0.17[0.016, 0.329] kg/m²; p < 0.05) handgrip strength 1.33[0.256, 2.410] kg; 0.05), differences between not statistically significant. However, observed lean (1.70 [0.749, 2.665] P 0.01) (0.62[0.287, 0.954] kg/m 2 ; groups. Weight was maintained arm, whereas arm experienced weight loss (1.87 [0.654, 3.109] 0.01). Participants did show changes parameters. most reported side effects appetite (50%) stomach heaviness (20.8%). Conclusion This mixture supplements significantly improved mass, preserved function, helped maintain weight, supporting its potential strategy counter enhance diabetic sarcopenia patients. Clinical trial registration is registered Iranian Registry Trials (IRCT) IRCT20230831059311N1 ID.

Language: Английский

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The association of sarcopenia and frailty in diabetes‐related foot disease: A 3‐year prospective evaluation

Journal of Foot and Ankle Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 1, 2025

Abstract Aim To prospectively evaluate the association of various markers sarcopenia and frailty with clinical outcomes in diabetes‐related foot disease (DRFD), namely wound healing, amputation‐free survival, death over 3 years. Methods This was an observational study patients DRFD at a quaternary multidisciplinary diabetic service. Initial assessment includes classification DRFDs using WIfI classification, FRAIL scale, measurement handgrip strength (HGS) dynamometer. Muscle mass ascertained by measuring psoas muscle area level L3 vertebrae on computed tomography. Patients were followed up for years primary death. Results One hundred median age 71 included analysis. The majority male (75%). Forty‐seven percent considered as frail, 37 recorded to have low HGS. high HGS had significantly higher odds healing 3.83 times when compared those (odds ratio = 3.83. 95% CI 1.35–10.92). index (PMI) observed risk based following hazard ratios: (high vs. low), HR 0.46, CI: 0.22–0.997; PMI (low high), 2.15, 1.17–3.96. Conclusion There significant prevalence reduced among our DRFD. Low associated poor increased mortality Additionally, this population. research highlights need more precise tests future studies links between sarcopenia, frailty,

Language: Английский

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Effects of Taekwondo training on thigh muscle cross-sectional area, health-related physical fitness, HbA1c, and GLP-1 in sedentary older women

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: April 3, 2025

Background Sedentary lifestyles in older individuals are associated with reduced physical function and an increased risk of metabolic diseases such as type 2 diabetes. Physical exercise can enhance muscle mass, insulin sensitivity, health. Taekwondo, a martial art that integrates both aerobic resistance components, may improve strength, balance, health individuals. This study investigated the effect long-term Taekwondo training on thigh cross-sectional area, related fitness, indicators sedentary women. Methods Seventeen participants (aged 65 years older, time 8 h more per day) were randomly assigned to group ( n = 9) control 8). Outcomes, including health-related Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Glucagon-like peptide-1 (GLP-1) measured before after program. The underwent 60 min training, three times week 12 weeks. Variable changes over between groups analyzed using two-way repeated measures ANOVA performed significant interactions. Results exhibited reduction body weight, mass index, fat, mean arterial blood pressure p &lt; 0.05), well lean lower limb 0.05). Improvements balance gait speed, stride observed indicating fall enhanced mobility. Laboratory analyses revealed triglyceride free fatty acids elevated HDL-cholesterol GLP-1 levels Increased area was inversely correlated fasting glucose, insulin, HOMA-IR, suggesting improved sensitivity glucose regulation. Conclusion Long-term fitness markers women, providing evidence its use effective intervention promote this population.

Language: Английский

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Development and validation of a predictive model for the risk of possible sarcopenia in middle-aged and older adult diabetes mellitus in China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

People with diabetes mellitus (DM) have a significantly increased risk of sarcopenia. A cross-sectional analysis was performed using nationally representative data to evaluate possible sarcopenia in middle-aged and older adults mellitus, develop validate prediction model suitable for the Chinese community. Data from China Health Retirement Longitudinal Study (CHARLS), which focuses on people 45 years age or older, served as basis model. CHARLS 2015 participants were used study, examined 53 factors. In order guarantee reliability, study split into two groups at random: 70% training 30% validation. Ten-fold cross-validation Least Absolute Shrinkage Selection Operator (LASSO) regression analyses determine best predictors The factors associated DM researched logistic models. Nomogram constructed predictive performance assessed area under curve (AUC), calibration curves decision (DCA). total 2,131 database collected passed final analysis, prevalence 28.9% (616/2131). Eight subsequently chosen models by LASSO regression: age, residence, body mass index, diastolic blood pressure, cognitive function, activities daily living, peak expiratory flow hemoglobin. These nomogram model, showed good accuracy agreement. AUC values validation sets 0.867 (95%CI: 0.847~0.887) 0.849 0.816~0.883). Calibration DCA indicated that exhibited performance. this can be probability adult DM, is helpful early identification intervention high-risk groups.

Language: Английский

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Antioxidant Diets and Lifestyles Could Mitigate the Risk of Sarcopenia with Low Muscle Mass in Women: A Retrospective Study

Healthcare, Journal Year: 2025, Volume and Issue: 13(8), P. 910 - 910

Published: April 15, 2025

Background: Sarcopenia is characterized by a loss of muscle mass, strength, and function. At present, there are no effective methods available for prevention or treatment. Oxidative Balance Score (OBS) has been shown to be significantly correlated with decreased risk sarcopenia. Nevertheless, gender-specific studies still exhibit certain limitations. Methods: Individuals who completed dual-energy X-ray absorptiometry the diet lifestyle questionnaires from National Health Nutrition Examination Survey were enrolled. OBSs calculated according dietary variables physical activity. low mass (SLM) was identified based on ratio appendicular skeletal body index. A logistic regression analysis investigated association between OBS SLM in different gender groups. Kaplan–Meier survival subgroup analyses Cox used explore relationship mortality individuals each subgroup. Results: The level group lower (20.40 vs. 17.07, p < 0.05). multivariate showed that OR individual nutrients exhibition gender-specific. Stratified revealed total OBS, as well negatively associated within (all 0.05, all trends Furthermore, restriction cubic spline females (nonlinear = 0.0469, nonlinear 0.0254). KM curve not all-cause male female subgroups (female, 0.064, male, 0.53). Conclusions: This study establishes significant negative correlation SLM, particularly among females. Consequently, adopting an antioxidant may prove more advantageous

Language: Английский

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