Transcriptional Pathways Predisposing to Cancer Oxidative Stress Sensitivity and Resistance Are Shared Between Hydrogen Peroxide and Cold Gas Plasma but Not Hypochlorous Acid DOI Open Access
Debora Singer, Sander Bekeschus

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 319 - 319

Published: Jan. 20, 2025

Oxidative stress is universal to all cell types, including cancer. It elicited by a surplus of reactive oxygen species (ROS) or reduced cellular ability defend against those. At low levels (oxidative eustress), this induces altered signaling, while at higher distress), toxicity and non-specific redox signaling become apparent. While oxidation-induced death hallmark many cancer therapies, ROS-producing radiotherapy, some chemotherapies targeted photodynamic therapy, recently emerging physical modalities such as medical gas plasma (a multi-ROS generating technology), less known about the transcriptional profiles predisposing cells oxidative demise. In particular, which genes are associated with resistance sensitivity ROS overload subsequent has not been systematically investigated. Moreover, it unclear if there differences between oxidant hydrogen peroxide hypochlorous acid. To end, we here employed 35 lines various origins (e.g., adenocarcinoma, melanoma, leukemia, squamous carcinoma, neuroblastoma). We first performed in-house transcriptomic analysis assess baseline profiles. Second, were exposed four different concentrations either peroxide, hypochlorous, exposure. Third, correlation was identify (i) sensitivity, (ii) resistance, (iii) similarities and/or inducers. Intriguingly, distinct gene sets found for treatments, striking difference acid, suggesting modes action both oxidants.

Language: Английский

Transcriptional Pathways Predisposing to Cancer Oxidative Stress Sensitivity and Resistance Are Shared Between Hydrogen Peroxide and Cold Gas Plasma but Not Hypochlorous Acid DOI Open Access
Debora Singer, Sander Bekeschus

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 319 - 319

Published: Jan. 20, 2025

Oxidative stress is universal to all cell types, including cancer. It elicited by a surplus of reactive oxygen species (ROS) or reduced cellular ability defend against those. At low levels (oxidative eustress), this induces altered signaling, while at higher distress), toxicity and non-specific redox signaling become apparent. While oxidation-induced death hallmark many cancer therapies, ROS-producing radiotherapy, some chemotherapies targeted photodynamic therapy, recently emerging physical modalities such as medical gas plasma (a multi-ROS generating technology), less known about the transcriptional profiles predisposing cells oxidative demise. In particular, which genes are associated with resistance sensitivity ROS overload subsequent has not been systematically investigated. Moreover, it unclear if there differences between oxidant hydrogen peroxide hypochlorous acid. To end, we here employed 35 lines various origins (e.g., adenocarcinoma, melanoma, leukemia, squamous carcinoma, neuroblastoma). We first performed in-house transcriptomic analysis assess baseline profiles. Second, were exposed four different concentrations either peroxide, hypochlorous, exposure. Third, correlation was identify (i) sensitivity, (ii) resistance, (iii) similarities and/or inducers. Intriguingly, distinct gene sets found for treatments, striking difference acid, suggesting modes action both oxidants.

Language: Английский

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