The Potential of Transcranial Direct Current Stimulation (tDCS) in Improving Quality of Life in Patients with Multiple Sclerosis: A Review and Discussion of Mechanisms of Action

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 373 - 373

Published: Jan. 9, 2025

Background/Objectives: Multiple sclerosis (MS) is the most prevalent incurable nontraumatic neurological disability in young individuals. It causes numerous symptoms, including tingling, fatigue, muscle spasms, cognitive deficits, and neuropsychiatric disorders. This disease significantly worsens quality of life (QoL), this dimension general functioning provides valuable information about effectiveness treatment well-being. There are psychological interventions that can improve QoL, but their number limited. Therefore, searching for new methods as effective safe possible ongoing. Methods: review examines potential transcranial direct current stimulation (tDCS) improving patients with MS. Searches were conducted PubMed/Medline, Research Gate, Cochrane databases. Results: The search yielded seven studies which QoL was a primary or secondary outcome. Stimulation protocols displayed heterogeneity, especially concerning choice site. Four demonstrated tDCS all (two) used anodal left DLPFC. motor cortex has produced mixed results. mechanisms action MS explained. These include improved synaptic plasticity, increased cerebral blood flow, salience network engagement through tDCS, reduction beta-amyloid deposition. limitations also detailed, recommendations future research made. Conclusions: While evidence limited, shown to some studies. Prefrontal appears promising, further recommended explore approach.

Language: Английский

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Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2003 - 2003

Published: March 29, 2024

Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) a cold-based physical therapy known to induce physiological exercise-mimicking changes cardiovascular, neuromuscular, immune, and endocrine systems influence functional psychological parameters by exposing human body cryogenic temperatures (≤−110 °C) for 2–3 min. The purpose this scoping review present an overall view on potential role WBC as adjuvant treatment MS. PubMed, ScienceDirect, Embase, Web Science were searched up 30 November 2023, total 13 articles included. may have beneficial antioxidant effects short-term There no significant enzymes, nitric oxide levels, metalloproteinase blood counts, rheology, biochemistry. can lead reduction fatigue improvement status, with effect both mental well-being. reported adverse effects. results suggest that complement therapeutic options patients MS, cold stimulation been shown activate processes improve mood, anxiety, fatigue.

Language: Английский

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Effectiveness of Ocrelizumab on Disease Progression and Disability Status in Multiple Sclerosis Patients: A Two-Year Prospective Cohort Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 553 - 553

Published: Jan. 16, 2025

Background and Objectives: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation neurodegeneration. Ocrelizumab, humanized anti-CD20 monoclonal antibody, has shown promise in reducing disease activity MS patients. This prospective study aims to assess the effectiveness of ocrelizumab confirmed disability progression patients with relapsing-remitting (RRMS) secondary progressive (SPMS) over two-year period. By evaluating clinical data, MRI findings, this seeks provide comprehensive insights into ocrelizumab's impact on dynamics disability. Materials Methods: Ninety-eight aged 18 65 were enrolled under therapy at Neurology Department "Pius Brinzeu" Clinical Emergency Hospital Romania between July 2020 2024. Participants assessed baseline every six months two years. The key outcomes measured changes Expanded Disability Status Scale (EDSS) as measure (CDP), annualized relapse rate (ARR), findings. Results: Over period, mean EDSS score significantly decreased from 5.2 ± 1.8 4.6 1.7 (mean change = -0.6 0.9; p 0.032), indicating improved neurological function. proportion experiencing relapses dropped markedly 61.2% 14.3% (p < 0.001). results showed significant reductions new or enlarging T2 lesions 68.4% 27.6% 0.001) gadolinium-enhancing 44.9% 15.3% Patients previously treated natalizumab exhibited greater reduction scores (-1.0 0.8; compared other treatments. Multivariate regression identified (β 0.65; 0.001), previous use -0.30; 0.013), age diagnosis 0.02; 0.048) predictors scores. While markers active decreased, brain atrophy increased 31.6% 43.9% (not statistically significant; 0.105). SPMS had higher rates (61.1% vs. 25.0%; 0.007) years (100.0% 31.3%; RRMS Conclusions: Ocrelizumab effectively reduced both Significant observed. Previous treatment was associated improvements. Despite these benefits, neurodegeneration, particularly patients, underscores need for additional strategies targeting neurodegenerative aspects MS.

Language: Английский

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The Associations of Mindfulness and Self-Compassion on Quality of Life for Patients with Multiple Sclerosis, a Cross-Sectional Study from Turkey

Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 18, 2025

Objective The aim of this study is to investigate the associations between self-compassion, mindfulness, emotional factors and multiple sclerosis (MS) related quality life among individuals with MS in Istanbul, Turkey.

Language: Английский

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Long-Term Management and Therapeutic Sequencing for Patients with Relapsing Multiple Sclerosis in France: A Vignette Study

Neurology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

We have analysed prescribing decisions for relapsing multiple sclerosis (RMS) of 111 neurologists ("participating physicians") in France using hypothetical case vignettes. Six vignettes were presented to participating physicians, each based on realistic, clinical interactions between a neurologist and people with active or highly RMS, without prior treatment disease-modifying therapy (DMT). "Disruptive events" are where the appearance new MS disease activity, side-effects other issues prompted return patients review their care. A population physicians reviewed cases recommended treatments. Our data suggested willingness among treat higher-efficacy DMTs early course platform agents given only one-quarter DMT-naïve cases. activity was main driver switches DMTs, although an escalation approach common response either moderate agents. desire pregnancy drove high usage cladribine tablets natalizumab (especially negative John Cunningham virus). These findings suggest that management RMS has shifted recent years towards achieve earlier more effective control RMS. Better guidance sequencing different scenarios within overall may be warranted. This study offers valuable insights into current practices French managing emphasizing complexity therapeutic decisions, diversity strategies, significance individualized management.

Language: Английский

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Evaluating patient care in multiple sclerosis: Impact of combined digital tools and holistic management strategies

Multiple Sclerosis Journal - Experimental Translational and Clinical, Journal Year: 2025, Volume and Issue: 11(2)

Published: April 1, 2025

Background Innovations are essential to meet the needs of people with MS (PwMS), particularly in addressing delays diagnosis and treatment, supporting patient self-management. Objectives To evaluate real-world use outcomes digital technologies holistic management strategies for at a UK Centre. Methods Digital tools PwMS included Patients Know Best (a personal health record) CONNECTPlus ® (an educational app). Tools healthcare professionals Infoflex clinical database MSProDiscuss assessing disease progression). A Healthy Lifestyle Clinic was introduced promote brain health. The impact these interventions on time-to-diagnosis, time-to-disease-modifying therapy (DMT) initiation, non-elective admissions, hospital costs evaluated retrospectively from 2018 2023, comparing pre-intervention (2018–2019) post-intervention (2020–2023) periods, while accounting separately COVID-19 years (2020–2021). Results Trends indicated higher likelihood progression patients delayed (p < 0.001), reduction time DMT an average 23.5 5.8 months = 0.024), post-MS implementation. Non-elective admissions also decreased compared neighbouring hospitals. Conclusions were associated positive trends care delivery. Further research is needed validate findings.

Language: Английский

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Evaluating the impact of systematic reporting of patient-reported outcome measures on depression and anxiety levels in people with multiple sclerosis: a randomized controlled trial

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106502 - 106502

Published: May 1, 2025

Language: Английский

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The therapeutic potential of exercise for improving mobility in multiple sclerosis

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS) with subsequent axonal neuronal degeneration. These changes are associated broad range of symptoms including skeletal muscle dysfunction. Importantly, musculoskeletal impairments manifest various ways, compromise quality life often precede later development mobility disability. As current standard modifying therapies for MS predominantly act on neuroinflammation, practitioners patients face an unmet medical need adjunct specifically targeting function. This review intended to detail nature dysfunctions common people (pwMS), describe underlying intramuscular alterations outline evidence-based therapeutic approaches. Particularly, we discuss emerging role aerobic resistance exercise reducing perception fatigue increasing strength pwMS. By integrating most recent literature, conclude that both interventions should ideally be implemented as early possible they can address MS-specific impairments. Aerobic particularly beneficial pwMS suffering from metabolic impairments, while training efficiently counters weakness improves fatigue. Thus, these lifestyle or pharmacological mimetics have potential improving general well-being delaying functional declines relevant mobility.

Language: Английский

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Risk Factors for Cognitive Impairment in Multiple Sclerosis Patients

Sclerosis, Journal Year: 2024, Volume and Issue: 2(2), P. 77 - 87

Published: March 22, 2024

Cognitive impairment is one of the most significant burdens among many neurological complaints in multiple sclerosis patients. deficits negatively impact these patients’ quality life, leading to partial or total loss several mental functions, such as learning, memory, perception, problem-solving. While precise mechanisms involved onset and evolution cognitive decline remain unknown, risk factors have been associated with intellectual disability. With increasing data on this topic recent years, main aim review summarize relevant correlated Firstly, authors demonstrate importance disability based epidemiological from patient cohorts. Subsequently, intensely debated major for are discussed, brief insights into pathophysiology possible underlying mechanisms. Finally, describe medication patients, highlighting research directions future studies.

Language: Английский

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Editorial: Trends in neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 18, 2024

Editorial: Trends in neuroimmunology: cross-talk between brain-resident and peripheral immune cells both health disease

Language: Английский

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