Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

Science, Journal Year: 2023, Volume and Issue: 380(6645), P. 619 - 624

Published: May 4, 2023

Major advances over the past decade in field of ancient DNA are providing access to paleogenomic diversity, but diverse functions and biosynthetic capabilities this growing paleome remain largely elusive. We investigated dental calculus 12 Neanderthals 52 anatomically modern humans ranging from 100,000 years ago present reconstructed 459 bacterial metagenome-assembled genomes. identified a gene cluster shared by seven Middle Upper Paleolithic individuals that allows for heterologous production class previously unknown metabolites we name "paleofurans." This paleobiotechnological approach demonstrates viable machinery can be produced preserved genetic material organisms, allowing natural products Pleistocene promising area product exploration.

Language: Английский

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The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1329 - 1329

Published: Aug. 17, 2023

The growing threat of antibiotic resistance is a significant global health challenge that has intensified in recent years. burden on public augmented due to its multifaceted nature, as well the slow-paced and limited development new antibiotics. posed by now existential phage therapy, which had long been touted promising replacement for Consequently, it imperative explore potential combination therapies involving antibiotics phages feasible alternative treating infections with multidrug-resistant bacteria. Although either bacteriophage or can potentially treat bacterial infections, they are each fraught resistance. Combination therapies, however, yielded positive outcomes most cases; nonetheless, few combinations did not show any benefit. comprising synergistic activity other treatments such probiotics hold promise treatment drug-resistant infections.

Language: Английский

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Impact of Antimicrobial Stewardship on Reducing Antimicrobial Resistance

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Antimicrobial resistance has become a serious global issue, posing significant threat to public health and healthcare professionals. Since the advent of penicillin, many antibiotics have lost their effectiveness in combating microbes simply due inappropriate, irrational, unnecessary, unrestricted use. The ineffectiveness an increasing number necessitates utilization more potent antimicrobial agents for combatting uncomplicated infections. In response escalating prevalence multidrug-resistant pathogens imperative curtail demand novel antibiotics, Stewardship Program was conceived implemented. This initiative is characterized by lead physician, ideally possessing expertise infectious diseases, alongside pharmacist serving as secondary leader microbiologist with defined responsibilities achieve several objectives. These objectives include reducing indiscriminate usage agents, promoting selective based on culture results, de-escalating therapy from broad-spectrum targeted transitioning parenteral oral administration when feasible. are pursued through combination pre-prescription post-prescription strategies. While widely established developed nations, pressing need exists its comprehensive implementation less regions. review aims examine strategies used stewardship programs evaluate preventing development organisms (MDROs) existing research studies. Under Program, education professionals continuous disposal information about helped restrict emergence organisms.

Language: Английский

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Green Onion (Allium fistulosum): An Aromatic Vegetable Crop Esteemed for Food, Nutritional and Therapeutic Significance

Foods, Journal Year: 2023, Volume and Issue: 12(24), P. 4503 - 4503

Published: Dec. 16, 2023

In recent years, there has been a shift towards greater demand for more nutritious and healthier foods, emphasizing the role of diets in human well-being. Edible Alliums, including common onions, garlic, chives green are staples diverse cuisines worldwide valued specifically their culinary versatility, distinct flavors nutritional medicinal properties. Green onions widely cultivated traded as spicy vegetable. The mild, onion-like flavor makes crop pleasant addition to various dishes, serving staple ingredient many world cuisines, particularly Eastern Asian countries such China, Japan Republic Korea. pseudostems, leaves non-developed bulbs utilized salads, stir-fries, garnishes myriad preparations. Additionally, have rich historical background traditional medicine diets, capturing attention chefs general public. status an important food, its diversity nutraceutical therapeutic value make it subject great interest research. Therefore, present review examined distribution, culinary, significance highlighting health benefits derived from consumption with this aromatic vegetable constituent.

Language: Английский

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Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7808 - 7808

Published: April 25, 2023

Biomaterial-based therapies have been receiving attention for treating microbial infections mainly to overcome the increasing number of drug-resistant bacterial strains and off-target impacts therapeutic agents by conventional strategies. A fibrous, non-soluble protein, collagen, is one most studied biopolymers development antimicrobial biomaterials owing its superior physicochemical, biomechanical, biological properties. In this study, we reviewed different approaches used develop collagen-based devices, such as non-pharmacological, antibiotic, metal oxide, peptide, herbal extract-based, combination approaches, with a particular focus on preclinical studies that published in last decade.

Language: Английский

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