Immunomodulation of cuproptosis and ferroptosis in liver cancer

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 10, 2024

Abstract According to statistics, the incidence of liver cancer is increasing yearly, and effective treatment imminent. For early cancer, resection surgery currently most treatment. However, does not treat disease in advanced patients, so finding a method with better prognosis necessary. In recent years, ferroptosis cuproptosis have been gradually defined, related studies proved that they show excellent results therapy cancer. Cuproptosis new form cell death, use combined inhibit production hepatocellular carcinoma cells has good development prospects worthy in-depth discussion by researchers. this review, we summarize research progress on treating analyze value immune propose potential pathways oncotherapy combination ferroptosis, which can provide background knowledge for subsequent research.

Language: Английский

---

Mechanism of metal ion-induced cell death in gastrointestinal cancer

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116574 - 116574

Published: April 8, 2024

Gastrointestinal (GI) cancer is one of the most severe types cancer, with a significant impact on human health worldwide. Due to urgent demand for more effective therapeutic strategies against GI cancers, novel research metal ions treating cancers has attracted increasing attention. Currently, accumulating relationship between and therapy, several have been discovered induce cell death. In particular, three modes death, including ferroptosis, cuproptosis, calcicoptosis, become focal points in field cancer. Meanwhile, other also found trigger death through various mechanisms. Accordingly, this review focuses mechanisms ion-induced hoping provide theoretical support further therapies.

Language: Английский

---

Proteomics-based identification of biomarkers reflecting endogenous and exogenous exposure to the advanced glycation end product precursor methylglyoxal in SH-SY5Y human neuroblastoma cells

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132859 - 132859

Published: June 1, 2024

Methylglyoxal (MGO), a highly reactive precursor of advanced glycation end products, is endogenously produced and prevalent in various food products. This study aimed to characterize protein modifications SH-SY5Y human neuroblastoma cells induced by MGO identify potential biomarkers for its exposure toxicity. A shot-gun proteomic analysis was applied treated with without exogenous MGO. Seventy-seven proteins were identified as susceptible modification, among which eight, including vimentin histone H2B type 2-F, showing concentration-dependent externally added MGO, defined exposure. Remarkably, up 10 modification sites on vimentin. Myosin light polypeptide 6 emerged biomarker toxicity, exclusively observed under cytotoxic levels. Additionally, like serine/threonine-protein kinase SIK2 calcyphosin, exhibiting comparable or even higher levels control compared MGO-treated cells, endogenous Bioinformatics revealed that motor proteins, cytoskeleton components, glycolysis overrepresented those modification. These results both provide insights into the cellular effects formed versus

Language: Английский

---

Genes Co-Expressed with ESR2 Influence Clinical Outcomes in Cancer Patients: TCGA Data Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8707 - 8707

Published: Aug. 9, 2024

ERβ has been assigned a tumor suppressor role in many cancer types. However, as conflicting findings emerge, ERβ’s tissue-specific expression and functional have remained elusive. There remains notable gap compact comprehensive analyses of ESR2 mRNA levels across diverse types coupled with an exploration its potential gene network. In this study, we aim to address these gaps by presenting analysis transcriptomic data. We distinguished significant changes compared corresponding healthy tissue concluded that influences patient survival. Gene Set Enrichment Analysis (GSEA) molecular pathways affected ESR2, including oxidative phosphorylation epithelial–mesenchymal transition. Finally, investigated genes displaying similar patterns tissues, identifying co-expressed may exert synergistic effect on clinical outcomes, results, the ACIN1, SYNE2, TNFRSF13C, MDM4. Collectively, our results highlight influence landscape overall metabolism cancerous cells various

Language: Английский

---

Mechanistic Insights into FNBP4-Mediated Regulation of non-diaphanous Formin FMN1 in Actin Cytoskeleton Dynamics

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

ABSTRACT Formin1 (FMN1), a member of the non-diaphanous formin family, is essential for development and neuronal function. Unlike diaphanous-related formins, FMN1 not subject to canonical autoinhibition through DID DAD domains, nor it activated by Rho GTPase binding. Recent studies suggest that formins also play roles in nucleus, influencing DNA damage response transcriptional regulation. However, mechanisms regulating nuclear particularly ones like remain poorly understood. Our previous research identified interaction between FNBP4, prompting further investigation into its functional role actin dynamics. Results reveal FNBP4 inhibits FMN1-mediated assembly vitro. It shown prevents from displacing capping protein CapZ at growing barbed end filaments. Additionally, FMN1’s bundling activity concentration-dependent manner. Further analysis indicates interacts with FH1 domain interdomain connector FH2 creating spatial constraints on domain. We propose acts as stationary inhibitor FMN1. In addition, we identify monopartite localization signal (NLS) subcellular show colocalizes This study provides new insights regulatory modulating dynamics, suggesting may function polymerization shedding light specific formins.

Language: Английский

---