CYP2C19 Loss-of-Function is an Associated Risk Factor for Premature Coronary Artery Disease: A Case–Control Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5049 - 5058

Published: Nov. 1, 2024

Objective: Cytochrome P450 2C19 (CYP2C19) is a major enzyme involved in the biotransformation and metabolism of various substances. Loss-of-function CYP2C19 gene represents downregulation indication limited or no enzymatic function, which may be, turn, associated with some disease susceptibility. The relationship between polymorphisms susceptibility to premature coronary artery (PCAD) not fully understood. This study aimed assess this relationship. Methods: included 635 PCAD patients, 548 age-matched non-CAD individuals as controls, from November 2019 August 2023. rs4244285 (681G > A, *2) rs4986893 (636G *3) were genotyped, distribution patients controls risk analyzed. Results: A total 442 (37.4%), 543 (45.9%), 198 (16.7%) had extensive metabolizer (EM) (*1/*1), intermediate (IM) (*1/*2 *1/*3), poor (PM) (*2/*2, *2/*3, *3/*3) phenotypes, respectively. *2/*2 genotype frequency was higher, *1/*1 lower than controls. Individuals PM phenotype higher triglyceride (TG) levels those EM IM phenotypes. Logistic regression analysis showed that body mass index (BMI) ≥ 24.0 kg/m 2 (≥ vs 18.5– 23.9 , odds ratio (OR): 1.326, 95% confidence interval (CI): 1.041– 1.688, p = 0.022), smoking (OR: 1.974, CI: 1.283– 3.306, 0.002), hypertension 1.327, 1.044– 1.687, 0.021), diabetes mellitus 1.390, 1.054– 1.834, 0.020), (PM phenotype, OR: 1.701, 1.200– 2.411, 0.003), IM+PM phenotypes (IM+PM 1.369, 1.077– 1.740, 0.010) PCAD. Conclusion: overweight, smoking, hypertension, Keywords: disease, cytochrome P450, CYP2C19, loss-of-function

Language: Английский

CYP2C19 Poor Metabolizer Status and High System Inflammation Response Index are Independent Risk Factors for Premature Myocardial Infarction: A Hospital-Based Retrospective Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 4959 - 4969

Published: Oct. 1, 2024

Atherosclerosis (AS) is a sustained chronic vascular inflammatory response caused by lipid metabolism disorders and immune the main cause of premature (men ≤ 55 years old, women 65 old) myocardial infarction (PMI). Cytochrome P450 2C19 (CYP2C19) (related to function metabolism) peripheral cell levels plays an important role in course AS. The association

Language: Английский

CYP2C19 loss-of-function variants are independent risk factors for premature cerebral infarction: a hospital based retrospective study

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 29, 2024

Abstract Objective Cytochrome P450 2C19 (CYP2C19) plays an vital role in the course of cardiovascular and cerebrovascular diseases by affecting lipid metabolism. Triglyceride-glucose (TyG) is a comprehensive index composed triglyceride blood glucose, has relationship with some diseases. There was no research report on association CYP2C19 polymorphisms, TyG premature cerebral infarction (CI) (onset ≤ 65 years old) susceptibility. Methods This study retrospectively analyzed 1953 CI patients aged old from December 2018 to March 2024, 1919 age-matched individuals non-CI as controls. The between risk were analyzed. Results proportion hypertension, diabetes mellitus higher than those serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), levels significantly controls (all p < 0.05). had lower *1 allele frequency (63.3% vs. 69.6%, 0.001) *2 (31.3% 25.4%, Logistic regression analysis showed that smoking history (odds ratio (OR): 1.193, 95% confidence interval (CI): 1.002–1.422, = 0.048), hypertension (OR: 3.371, CI: 2.914–3.898, 0.001), 1.911, 1.632–2.237, intermediate metabolizer (IM) + poor (PM) phenotypes 1.424, 1.243–1.631, dyslipidemia 1.294, 1.077–1.554, 0.006) independent factors for CI. Conclusions History smoking, mellitus, dyslipidemia, IM PM independently associated

Language: Английский