Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104674 - 104674

Published: Feb. 1, 2025

Language: Английский

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piRNAs in leukemogenesis: Mechanisms, biomarkers, and therapeutic implications

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120220 - 120220

Published: March 1, 2025

Language: Английский

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Neuroprotective effects of hirudin against cerebral ischemia-reperfusion injury via inhibition of CCL2-mediated ferroptosis and inflammatory pathways

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111293 - 111293

Published: March 1, 2025

Cerebral ischemia-reperfusion injury (CIRI) is a leading cause of neurological impairment in stroke, primarily correlated to oxidative stress, inflammation, and ferroptosis. This study investigates the neuroprotective effects hirudin on CIRI, focusing its role modulating neuronal survival, ferroptosis markers through inhibition CCL2. A middle cerebral artery occlusion (MCAO) model mice an oxygen-glucose deprivation/reoxygenation (OGD/R) HT22 cells were used simulate ischemic conditions. Hirudin significantly improved function reduced edema infarct size MCAO model. In vitro, enhanced viability apoptosis OGD/R-stimulated cells. Integrative network pharmacology transcriptomic analysis identified CCL2 as potential target hirudin. treatment suppressed expression, which turn TLR4/NF-κB signaling activation, thereby mitigating inflammatory responses neurons. Overexpression partially reversed these protective effects, underscoring injury. These findings suggest that alleviates CIRI by preventing ferroptosis, offering insights into therapeutic agent for

Language: Английский

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Artificial intelligence in stroke rehabilitation: From acute care to long-term recovery

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Identification of Potential Therapeutic Targets for Stroke Using Data Mining, Network Analysis, Enrichment, and Docking Analysis

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108431 - 108431

Published: March 1, 2025

Language: Английский

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Toll-Like Receptors in Kidney Ischemia-Reperfusion Injury: Modulating Macrophage Responses for Therapeutic Insights

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155940 - 155940

Published: March 1, 2025

Language: Английский

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Enhancing neurological disease diagnostics: fusion of deep transfer learning with optimization algorithm for acute brain stroke prediction using facial images

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 10, 2025

Language: Английский

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Risk factors for mild cognitive impairment in type 2 diabetes mellitus older adult: a systematic review and meta-analysis

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 186, P. 445 - 457

Published: April 22, 2025

Language: Английский

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An alternative synthetic approach for the construction of Tafamidis analogues and its novel derivatives

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101739 - 101739

Published: April 1, 2025

Language: Английский

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Matrix metalloproteinase-9 (MMP-9): A macromolecular mediator in CNS infections: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143902 - 143902

Published: May 4, 2025

Language: Английский

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