Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation DOI
Karthick Harini, Koyeli Girigoswami, Anbazhagan Thirumalai

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: Sept. 30, 2024

Language: Английский

A potential strategy against clinical carbapenem-resistant Enterobacteriaceae: antimicrobial activity study of sweetener-decorated gold nanoparticles in vitro and in vivo DOI Creative Commons
Haifeng Liu,

Zeyu Huang,

Huanchang Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 6, 2023

Carbapenem-resistant Enterobacteriaceae (CRE) present substantial challenges to clinical intervention, necessitating the formulation of novel antimicrobial strategies counteract them. Nanomaterials offer a distinctive avenue for eradicating bacteria by employing mechanisms divergent from traditional antibiotic resistance pathways and exhibiting reduced susceptibility drug development. Non-caloric artificial sweeteners, commonly utilized in food sector, such as saccharin, sucralose, acesulfame, aspartame, possess structures amenable nanomaterial formation. In this investigation, we synthesized gold nanoparticles decorated with non-caloric sweeteners evaluated their efficacy against CRE strains.Among these, aspartame (ASP_Au NPs) exhibited most potent effect, displaying minimum inhibitory concentrations ranging 4 16 µg/mL. As result, ASP_Au NPs were chosen further experimentation. Elucidation mechanism unveiled that substantially elevated bacterial reactive oxygen species (ROS) levels, which dissipated upon ROS scavenger treatment, indicating accumulation within fundamental modality. Furthermore, findings membrane permeability assessments suggested may represent secondary modality via enhancing inner permeability. addition, experiments involving crystal violet confocal live/dead staining demonstrated effective suppression biofilm formation NPs. Moreover, notable treatment Galleria mellonella infection acute abdominal mice, concurrently mitigating organism's inflammatory response. Crucially, evaluation vivo safety biocompatibility established negligible toxicity at bactericidal concentrations.Our results exhibit promise innovative agents CRE.

Language: Английский

Citations

12
Current developments and prospects of the antibiotic delivery systems DOI

Kusum Kharga,

Shubhang Jha,

Tanvi Vishwakarma

et al.

Critical Reviews in Microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 40

Published: Feb. 29, 2024

Antibiotics have remained the cornerstone for treatment of bacterial infections ever since their discovery in twentieth century. The uproar over antibiotic resistance among bacteria arising from genome plasticity and biofilm development has rendered current therapies ineffective, urging innovative therapeutic approaches. further heightened clinical failure therapy, which is often linked to its low bioavailability, side effects, poor penetration accumulation at site infection. In this review, we highlight potential use siderophores, antibodies, cell-penetrating peptides, antimicrobial bacteriophages, nanoparticles smuggle antibiotics across impermeable biological membranes achieve therapeutically relevant concentrations combat (AMR). We will discuss general mechanisms via each delivery system functions how it can be tailored deliver against paradigm underlying resistance.

Language: Английский

Citations

5
Antibacterial, Antibiofilm, and Quorum Quenching Properties of Biogenic Chitosan Silver Nanoparticles Against Staphylococcus aureus DOI

Reem Mahdi Saleh,

Omar M. Hassan

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4456 - 4468

Published: July 31, 2024

Language: Английский

Citations

5
Antibacterial and antibiofilm activity of silver nanoparticles stabilized with C-phycocyanin against drug-resistant Pseudomonas aeruginosa and Staphylococcus aureus DOI Creative Commons
Zahra Chegini, Aref Shariati, Mohammad Yousef Alikhani

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 23, 2024

Biofilms are bacterial communities that can protect them against external factors, including antibiotics. In this study, silver nanoparticles (AgNPs) were formed by modifying AgNPs with C-phycocyanin (Ag-Pc) to inhibit the growth of carbapenem-resistant

Language: Английский

Citations

5
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation DOI
Karthick Harini, Koyeli Girigoswami, Anbazhagan Thirumalai

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: Sept. 30, 2024

Language: Английский

Citations

4