Antibacterial and antibiofilm activities of ZIF-67

The Journal of Antibiotics, Journal Year: 2023, Volume and Issue: 76(10), P. 603 - 612

Published: June 19, 2023

Abstract Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide. Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore, the discovery new antibacterial antibiofilm compounds is an issue paramount importance combat prevent hard-to-treat bacterial infections. Zeolitic-imidazolate-frameworks (ZIFs) are metallo-organic known have various interesting chemical biological applications, including properties. In this study, we synthesized ZIF-67 nanoparticles, formed by imidazolate anions cobalt cations, found that they inhibit growth Acinetobacter baumannii , Pseudomonas aeruginosa Staphylococcus aureus . Sub-inhibitory concentrations were also able significantly reduce biomass pre-established biofilms these pathogenic On other hand, nanoparticles had null or low cytotoxicity in mammalian cells at those showing activities. Thus, our results reveal potential be used against

Language: Английский

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Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 12, 2023

Abstract Oxidative damage and infection can prevent or delay tissue repair. Moreover, reinforces reactive oxygen species (ROS) formation, which makes the wound's condition even worse. Therefore, need for antioxidant antibacterial agents is felt regeneration. There are emerging up‐and‐coming biomaterials that recapitulate both properties into a package, offering an effective solution to turn wound back healing state. In this article, principles of activity summarized. The review starts with biological aspects, getting readers familiarize themselves barriers against infection. This followed by chemistry mechanism action materials (dual function). Eventually, outlook challenges underlined provide where dual‐function they going in future. It expected present article inspires designing more advanced levels providing fundamentals comparative points view paving clinical way these materials.

Language: Английский

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Antimicrobial and anti-biofilm activity of silver nanoparticles biosynthesized with Cystoseira algae extracts

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2023, Volume and Issue: 28(4), P. 439 - 450

Published: April 21, 2023

Antimicrobial resistance is an ever-growing global concern to public health with no clear or immediate solution. Silver nanoparticles (AgNPs) have long been proposed as efficient agents fight the growing number of antibiotic-resistant strains. However, synthesis these particles often linked high costs and use toxic, hazardous chemicals, environmental impact. In this study, we successfully produced AgNPs by green aid extract two brown algae-Cystoseira baccata (CB) Cystoseira tamariscifolia (CT)-and characterized their physico-chemical properties. The NPs in both cases (Ag@CB Ag@CT) present similar sizes, mean diameters around 22 nm. antioxidant activity extracts was evaluated, showing important activity. bacteriostatic bactericidal properties Ag@CB Ag@CT were tested compared gold same algae previously reported. demonstrated strongest properties, at concentrations low 2.16 µg/mL against Pseudomonas aeruginosa Escherichia coli. Finally, capacity samples prevent formation biofilms characteristic infections a poorer outcome assessed, obtaining results. This work points towards alternative for treatment bacterial infections, even biofilm-inducing, possibility minimizing risk drug resistance, albeit necessary caution implied using metallic NPs.

Language: Английский

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Gold-Based Nanostructures for Antibacterial Application

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10006 - 10006

Published: June 11, 2023

Bacterial infections have become a fatal threat because of the abuse antibiotics in world. Various gold (Au)-based nanostructures been extensively explored as antibacterial agents to combat bacterial based on their remarkable chemical and physical characteristics. Many Au-based designed activities mechanisms further examined demonstrated. In this review, we collected summarized current developments nanostructures, including Au nanoparticles (AuNPs), nanoclusters (AuNCs), nanorods (AuNRs), nanobipyramids (AuNBPs), nanostars (AuNSs) according shapes, sizes, surface modifications. The rational designs these are discussed. With novel agents, also provide perspectives, challenges, opportunities for future practical clinical applications.

Language: Английский

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A review on recent trends of the antibacterial nonwovens air filter materials: Classification, fabrication, and application

Separation and Purification Technology, Journal Year: 2023, Volume and Issue: 330, P. 125404 - 125404

Published: Oct. 18, 2023

Language: Английский

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