From stem cells to extracellular vesicles: a new horizon in tissue engineering and regenerative medicine DOI
Gajanan K Arbade,

Jovel Varghese Jose,

Arvind Gulbake

et al.

Cytotechnology, Journal Year: 2024, Volume and Issue: 76(4), P. 363 - 401

Published: May 8, 2024

Language: Английский

A Comprehensive Exploration of Therapeutic Strategies in Inflammatory Bowel Diseases: Insights from Human and Animal Studies DOI Creative Commons
Inês E. Dias, Isabel R. Dias, Teresa Franchi-Mendes

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 735 - 735

Published: March 26, 2024

Inflammatory bowel disease (IBD) is a collective term for group of chronic inflammatory enteropathies which are characterized by intestinal inflammation and persistent or frequent gastrointestinal signs. This affects more than 3.5 million humans worldwide presents some similarities between animal species, in particular, dogs cats. Although the underlying mechanism that triggers not yet well understood, evidence suggests multifactorial etiology implicating genetic causes, environmental factors, microbiota imbalance, mucosa immune defects, both Conventional immunomodulatory drug therapies, such as glucocorticoids immunosuppressants, related with numerous adverse effects limit its long-term use, creating need to develop new therapeutic strategies. Mesenchymal stromal cells (MSCs) emerge promising alternative attenuates modulating cytokines inflamed tissues, also due their pro-angiogenic, anti-apoptotic, anti-fibrotic, regenerative, anti-tumor, anti-microbial potential. However, this approach may have important limitations regarding lack studies, namely veterinary medicine, standardized protocols, high economic cost. review summarizes main differences human, canine, feline IBD, potential treatment future prospects MSCs.

Language: Английский

Citations

4
IsoalloLCA-intervened regulatory T cell exosomes alleviate inflammatory bowel disease by inhibiting NF-κB-associated inflammation in intestinal epithelial cells DOI
Sim Ray Yue, Ling Gong,

Yulin L. Tan

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114501 - 114501

Published: April 12, 2025

Language: Английский

Citations

0
Targeted Nanomedicines for the Treatment of Helicobacter pylori Infection DOI Creative Commons

Shi Wang,

Hao Ding, Li Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101820 - 101820

Published: April 1, 2025

Language: Английский

Citations

0
Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases DOI Creative Commons

Kecheng Lou,

Hui Luo,

Xinghua Jiang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

The emerging extracellular vesicles technologies is an advanced therapeutic approach showing promising potential for addressing inflammatory diseases. These techniques have been proven to positive effects on immune modulation and anti-inflammatory responses. With these advancements, a comprehensive review update the role of in diseases become timely. This aims summarize research progress vesicle such as plant-derived vesicles, milk-derived mesenchymal stem cell-derived macrophage-derived etc., treatment It elucidates their significance regulating inflammation, promoting tissue repair, treating goal provide insights future this field, fostering application development technology

Language: Английский

Citations

3
From stem cells to extracellular vesicles: a new horizon in tissue engineering and regenerative medicine DOI
Gajanan K Arbade,

Jovel Varghese Jose,

Arvind Gulbake

et al.

Cytotechnology, Journal Year: 2024, Volume and Issue: 76(4), P. 363 - 401

Published: May 8, 2024

Language: Английский

Citations

3