Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 19, 2023
Malignant
melanoma
(MM)
is
the
most
common
and
deadliest
type
of
skin
cancer
associated
with
high
mortality
rates
across
all
races
ethnicities.
Although
present
treatment
options
combined
surgery
provide
short-term
clinical
benefit
in
patients
early
diagnosis
non-metastatic
MM
significantly
increases
probability
survival,
no
efficacious
treatments
are
available
for
MM.
The
etiology
pathogenesis
complex.
Acquired
drug
resistance
a
pool
prognosis
advanced-stage
Thus,
these
require
new
therapeutic
strategies
to
improve
their
response
prognosis.
Multiple
studies
have
revealed
that
ferroptosis,
non-apoptotic
form
regulated
cell
death
(RCD)
characterized
by
iron
dependant
lipid
peroxidation,
can
prevent
development
Recent
indicated
targeting
ferroptosis
promising
strategy
This
review
article
summarizes
core
mechanisms
underlying
cells
its
potential
role
as
target
We
emphasize
emerging
types
small
molecules
inducing
pathways
boosting
antitumor
activity
BRAFi
immunotherapy
uncover
beneficial
effects
treat
also
summarize
application
nanosensitizer-mediated
unique
dynamic
ferroptosis-based
nanodrug
suggests
pharmacological
induction
may
be
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: May 28, 2024
The
article
discusses
the
promising
synergy
between
MXenes
and
polymers
in
developing
advanced
nanocomposites
with
diverse
applications
biomedicine
domains.
MXenes,
possessing
exceptional
properties,
are
integrated
into
polymer
matrices
through
various
synthesis
fabrication
methods.
These
find
drug
delivery,
imaging,
diagnostics,
environmental
remediation.
They
offer
improved
therapeutic
efficacy
reduced
side
effects
enhanced
sensitivity
specificity
imaging
effectiveness
water
purification
pollutant
removal.
perspective
also
addresses
challenges
like
biocompatibility
toxicity,
while
suggesting
future
research
directions.
In
totality,
it
highlights
transformative
potential
of
MXenes-polymer
addressing
critical
issues
across
fields.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 12, 2024
Abstract
Photothermal
therapy
is
favored
by
cancer
researchers
due
to
its
advantages
such
as
controllable
initiation,
direct
killing
and
immune
promotion.
However,
the
low
enrichment
efficiency
of
photosensitizer
in
tumor
site
limited
effect
single
use
limits
further
development
photothermal
therapy.
Herein,
a
photo-responsive
multifunctional
nanosystem
was
designed
for
therapy,
which
myeloid-derived
suppressor
cell
(MDSC)
membrane
vesicle
encapsulated
decitabine-loaded
black
phosphorous
(BP)
nanosheets
(BP@
Decitabine
@MDSCs,
named
BDM).
The
BDM
demonstrated
excellent
biosafety
biochemical
characteristics,
providing
suitable
microenvironment
killing.
First,
achieves
ability
be
highly
enriched
at
sites
inheriting
MDSCs
actively
target
microenvironment.
And
then,
BP
hyperthermia
induces
mitochondrial
damage
photodynamic
properties,
enhancing
anti-tumor
immunity
mediated
immunogenic
death
(ICD).
Meanwhile,
intra-tumoral
release
decitabine
induced
G2/M
cycle
arrest,
promoting
apoptosis.
In
vivo,
BMD
showed
significant
inhibition
growth
with
down-regulation
PCNA
expression
increased
high
mobility
group
B1
(HMGB1),
calreticulin
(CRT)
caspase
3.
Flow
cytometry
revealed
significantly
decreased
infiltration
M2-macrophages
along
an
proportion
CD4
+
,
CD8
T
cells
well
CD103
DCs,
suggesting
potentiated
response.
summary,
realizes
therapy/photodynamic
synergized
chemotherapy
cancer.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10875 - 10875
Published: June 29, 2023
The
rapid
rise
in
research
and
development
following
the
discovery
of
photodynamic
therapy
to
establish
novel
photosensitizers
overcome
limitations
technology
soon
after
its
clinical
translation
has
given
a
few
significant
milestones.
These
include
several
generations
photosensitizers,
widening
scope
applications,
leveraging
offerings
nanotechnology
for
greater
efficacy,
selectivity
disease
over
host
tissue
cells,
advent
combination
therapies
with
other
similarly
minimally
invasive
therapeutic
technologies,
use
stimulus-responsive
delivery
targeting,
penetration
depth
activation
energy.
Brought
together,
all
these
milestones
have
contributed
enhancement
what
is
still
arguably
technology.
Yet
major
applications
remain
firmly
located
neoplasms,
from
where
most
new
innovations
appear
launch
areas,
such
as
microbial,
fungal,
viral,
acne,
wet
age-related
macular
degeneration,
atherosclerosis,
psoriasis,
environmental
sanitization,
pest
control,
dermatology.
Three
main
value
propositions
combinations
synergistic
additive
relatively
low
emergence
resistance
targeted
high-precision
therapy.
Combinations
established
methods
chemotherapy
radiotherapy
demonstrated
mop-up
surgery
promise
enhance
top
three
tools.
From
published
vitro
preclinical
studies,
trials
postclinical
case
seven
become
prominent
interests
because
they
are
potentially
easily
applied,
showing
enhanced
rapidly
translating
clinic.
chemotherapy,
photothermal
therapy,
magnetic
hyperthermia,
cold
plasma
sonodynamic
immunotherapy,
radiotherapy.
Photochemical
internalization
critical
mechanism
some
combinations.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 19, 2023
Malignant
melanoma
(MM)
is
the
most
common
and
deadliest
type
of
skin
cancer
associated
with
high
mortality
rates
across
all
races
ethnicities.
Although
present
treatment
options
combined
surgery
provide
short-term
clinical
benefit
in
patients
early
diagnosis
non-metastatic
MM
significantly
increases
probability
survival,
no
efficacious
treatments
are
available
for
MM.
The
etiology
pathogenesis
complex.
Acquired
drug
resistance
a
pool
prognosis
advanced-stage
Thus,
these
require
new
therapeutic
strategies
to
improve
their
response
prognosis.
Multiple
studies
have
revealed
that
ferroptosis,
non-apoptotic
form
regulated
cell
death
(RCD)
characterized
by
iron
dependant
lipid
peroxidation,
can
prevent
development
Recent
indicated
targeting
ferroptosis
promising
strategy
This
review
article
summarizes
core
mechanisms
underlying
cells
its
potential
role
as
target
We
emphasize
emerging
types
small
molecules
inducing
pathways
boosting
antitumor
activity
BRAFi
immunotherapy
uncover
beneficial
effects
treat
also
summarize
application
nanosensitizer-mediated
unique
dynamic
ferroptosis-based
nanodrug
suggests
pharmacological
induction
may
be
