Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation DOI Creative Commons

Pei-Wei Weng,

Chia‐Hung Liu,

Pei-Ru Jheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 8, 2024

Abstract Thrombotic cardiovascular diseases are a prevalent factor contributing to both physical impairment and mortality. Thrombolysis ischemic mitigation have emerged as leading contemporary therapeutic approaches for addressing the consequences of injury reperfusion damage. Herein, an innovative cellular-cloaked spermatozoon-driven microcellular submarine (SPCS), comprised multimodal motifs, was designed integrate nano-assembly thrombolytics with immunomodulatory ability derived from innate magnetic hyperthermia. Rheotaxis-based navigation utilized home cross clot barrier, finally accumulate in vascular organs, where thrombolytic motif “switched-on” by action thrombus red blood cell-driven In murine model, SPCS system combining hyperthermia demonstrated capacity augment delivery efficacy, produce nanotherapeutic outcomes, exhibit potent activity, ameliorate tissue These findings underscore multifaceted potential our approach, offering ischemia-mitigating effects. Given its extended effects thrombus-targeting capability, this biocompatible holds promise agent enhancing efficacy preventing risks after managing thrombosis. Graphical abstract

Language: Английский

Combination Using Magnetic Iron Oxide Nanoparticles and Magnetic Field for Cancer Therapy DOI

Wenjun Sun,

Xiaoxia Chai,

Yuan Zhang

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Iron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing fields have also gathered increasing attention the biomedical field. However, defects of difficult dispersion poor biocompatibility MNPs seriously hinder application. In order overcome its inherent maximize therapeutic potential MNPs, various functionalized been developed, numerous combined methods based on widely studied. this review, we compare analyze common with different sizes, shapes, functional modifications. Additionally, introduced mechanisms strategies, such as magnetically controlled targeting, hyperthermia, magneto‐mechanical effect, which unique induction capabilities MNPs. Finally, main challenges smart nanomaterials were discussed. This review seeks offer a thorough overview biomedicine new sight for application tumor treatment.

Language: Английский

Citations

2
Iron oxide nanoparticles: a versatile nanoplatform for the treatment and diagnosis of ovarian cancer DOI
Neelam Poonia, Vipan Kumar,

Rudra Narayan Subudhi

et al.

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 26, 2024

Ovarian cancer remains one of the main causes human mortality, accounting for millions deaths every year. Despite several clinical options such as chemotherapy, photodynamic therapy (PDT), hormonal treatment, radiation therapy, and surgery to manage this disease, mortality rate is still very high. This alarming statistic highlights urgent need innovative approaches improve both diagnosis treatment. Success stories iron oxide nanoparticles, i.e. Ferucarbotran (Resovist®) Ferrixan (Cliavist®) liver imaging, CNS (Central nervous system) cell labeling, etc. have motivated researchers explore these nanocarriers treatment different diseases. Iron nanoparticles improved therapeutic efficacy anticancer drugs through targeted delivery, heat/ROS (reactive oxygen species) generation on application external energy also shown great potential contrast agents magnetic resonance imaging (MRI). Their unique properties enable sensitive surface modification allows attachment specific biomolecules detection ovarian cells. properties, viz. responsiveness functionalization, make them versatile tools enhancing outcomes. Present article reviews literature synthesis, applications in management cancer.

Language: Английский

Citations

2
Bio-intelligent plasma-engineered diferuloylmethane/fucoidan/neutrophil lysate/iron oxide nanoclusters for phototherapeutic and magnetotherapeutic with in situ magnetic gelation mitigating inflammatory diseases DOI
Andrew E.‐Y. Chuang,

Yung-Wei Lin,

Pei‐Ru Jheng

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 243, P. 114054 - 114054

Published: July 4, 2024

Language: Английский

Citations

1
Light‐Driven Green‐Fabricated Artificial Intelligence‐Enabled Micro/Nanorobots for Multimodal Phototherapeutic Management of Bladder Cancer DOI

Chi‐Hung Hsiao,

Yung‐Wei Lin,

Chia‐Hung Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Abstract Combination therapy based on precise phototherapies combined with immune modulation provides successful antitumor effects. In this study, a combination is designed phototactic, photosynthetic, and phototherapeutic Chlamydomonas Reinhardtii (CHL)‐glycol chitosan (GCS)‐polypyrrole (PPy) nanoparticle (NP)‐enhanced immunity the tumor microenvironment turnover of cytotoxic T cells M1/M2 macrophages, which photothermal GCS‐PPy NPs decorated onto phototactic photosynthetic CHL. Phototherapy CHL‐GCS‐PPy alleviates hypoxia modulates microenvironment, induces cell death. particular, response potent memory induced by combining self‐navigated significantly alleviate progression bladder cancer in C57BL/6 mice effectively inhibit growth. Furthermore, they also potentially prevent recurrence, promising therapeutic strategy for clinical therapy.

Language: Английский

Citations

1
A novel water-soluble polymer nanocomposite containing ultra-small Fe3O4 nanoparticles with strong antibacterial and antibiofilm activity DOI
Г. Ф. Прозорова, A. I. Emel’yanov, А. А. Иванова

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

A novel water-soluble polymer nanocomposite with ultra-small iron oxide nanoparticles intercalated into a biocompatible matrix of 1-vinyl-1,2,4-triazole and N -vinylpyrrolidone copolymer exhibits pronounced antibacterial antibiofilm activity.

Language: Английский

Citations

1
Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation DOI Creative Commons

Pei-Wei Weng,

Chia‐Hung Liu,

Pei-Ru Jheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 8, 2024

Abstract Thrombotic cardiovascular diseases are a prevalent factor contributing to both physical impairment and mortality. Thrombolysis ischemic mitigation have emerged as leading contemporary therapeutic approaches for addressing the consequences of injury reperfusion damage. Herein, an innovative cellular-cloaked spermatozoon-driven microcellular submarine (SPCS), comprised multimodal motifs, was designed integrate nano-assembly thrombolytics with immunomodulatory ability derived from innate magnetic hyperthermia. Rheotaxis-based navigation utilized home cross clot barrier, finally accumulate in vascular organs, where thrombolytic motif “switched-on” by action thrombus red blood cell-driven In murine model, SPCS system combining hyperthermia demonstrated capacity augment delivery efficacy, produce nanotherapeutic outcomes, exhibit potent activity, ameliorate tissue These findings underscore multifaceted potential our approach, offering ischemia-mitigating effects. Given its extended effects thrombus-targeting capability, this biocompatible holds promise agent enhancing efficacy preventing risks after managing thrombosis. Graphical abstract

Language: Английский

Citations

0