Study on the Antibacterial Activity and Bone Inductivity of Nanosilver/PLGA-Coated TI-CU Implants

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6427 - 6447

Published: June 1, 2024

Background: Implants are widely used in the field of orthopedics and dental sciences. Titanium (TI) its alloys have become most implant materials, but implant-associated infection remains a common serious complication after surgery. In addition, titanium exhibits biological inertness, which prevents implants bone tissue from binding strongly may cause to loosen fall out. Therefore, preventing improving their induction ability important goals. Purpose: To study antibacterial activity titanium–copper alloy coated with nanosilver/poly (lactic-co-glycolic acid) (NSPTICU) provide new approach for inhibiting promoting integration. Methods: We first examined vitro osteogenic NSPTICU by studying proliferation differentiation MC3T3-E1 cells. Furthermore, induce SD rats was studied micro-computed tomography (micro-CT), hematoxylin-eosin (HE) staining, masson immunohistochemistry van gieson (VG) staining. The gram-positive Staphylococcus aureus (Sa) gram-negative Escherichia coli (E. coli) bacteria. Sa as test bacterium, implanted gross view specimen collection, bacterial colony counting, HE staining Giemsa Results: Alizarin red alkaline phosphatase (ALP) quantitative real-time polymerase chain reaction (qRT-PCR) western blot analysis showed that promoted antimicrobial results exhibited better properties. Animal experiments can inhibit inflammation promote repair defects. Conclusion: has excellent ability, broad application prospects treatment defects related Keywords: nanosilver/PLGA coating, infection, antibacterial, osteogenesis, copper

Language: Английский

The oral microbiota and periodontal health in orthodontic patients

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from parents by 4 years‐of‐age. plays an important role in overall health/symbiosis individual. Deviations state symbiosis leads to dysbiosis increased risk pathogenicity. can occur not only daily life activities but also orthodontic interventions. Orthodontic appliances are formed a variety biomaterials. Once inserted, they serve as breeding ground for microbial attachment, new surface areas crevices material physicochemical interactions different than symbiotic state. Individuals undergoing treatment show, compared with untreated people, qualitative quantitative differences activity microbiota, induced retention supra‐ subgingival plaque throughout period. These changes at root main undesirable effects, such gingivitis, white spot lesions (WSL), more severe caries lesions. Notably, profile weeks intervention might be valuable indicator predict identify higher‐risk individuals respect periodontal health otherwise healthy population. Antimicrobial coatings have been used dissuade microbes adhering biomaterial; however, disrupt host several bacterial strains become resistant. Smart biomaterials that reduce antimicrobial load preventing adhesion shown promising results, their complexity has kept many solutions reaching clinic. 3D printing technology provides opportunities complex chemical syntheses performed uniformly, reducing cost producing smart giving hope may reach clinic near future. purpose this review is emphasize importance during therapy use innovative technologies better maintain its balance surgical procedures.

Language: Английский

Synergistic effects of calcium and zinc on bio-functionalized 3D Ti cancellous bone scaffold with enhanced osseointegration capacity in rabbit model

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 166, P. 214070 - 214070

Published: Oct. 13, 2024

Language: Английский