Algae-derived bioactive compounds as potential pharmaceuticals for cancer therapy: A comprehensive review

Algal Research, Journal Year: 2024, Volume and Issue: 78, P. 103396 - 103396

Published: Jan. 18, 2024

Cancer is considered a pandemic, costing precious lives throughout the globe. Besides its deadly outcomes, survival rate after cancer therapies meager. Anti-cancer drug resistance and cytotoxicity are leading causes of poor prognosis anticancer treatments. Though advancements in genetic engineering, nanotechnology, bioinformatics revolutionized discovery development, importance natural compounds for development indispensable. Algae reservoirs distinctive chemical entities offer promising line research. Chemotherapy has been beneficial up to now, but it also comes with quite undesirable side effects. algae-derived products an area that revolutionizing itself as these less poisonous, quicker, cheaper, safer, more environmentally friendly than traditional treatment approaches. Complementary alternative extracted from marine or freshwater flora, particularly prokaryotic eukaryotic algae, have studied their pharmaceutical potential. However, application nutraceuticals still infancy. Algae, autotrophic organism, most untapped richest source compounds. Through this comprehensive review, efforts made draw attention recent significant achievements algae-based therapeutics target nuclear cellular components. Additionally, challenges solutions discussed detail.

Language: Английский

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Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 318 - 318

Published: Jan. 20, 2025

Algae are a rich source of bioactive compounds that have wide range beneficial effects on human health and can show significant potential in the treatment hematological malignancies such as leukemia, lymphoma, multiple myeloma. These diseases often pose therapeutic challenge despite recent advances (e.g., use immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, targeted therapy). A considerable number patients experience relapses or resistance to applied therapies. Algal compounds, alone combination with chemotherapy other more advanced therapies, exhibited antitumor preclinical studies may improve disease outcomes. include ability induce apoptosis, inhibit tumor growth, immune responses. However, most these conducted vitro, without vivo validation clinical trials. This paper summarizes current evidence vitro algae extracts isolated myeloma lines. In addition, we address application algae-derived drug carriers their synergistic against hematologic malignancies.

Language: Английский

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Phytochemical analysis, antioxidant activity, and cytotoxic effects of Caulerpa lentillifera extracts inducing cell apoptosis and sub-G/G0-G1 cell cycle arrest in KON oral cancer cells

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 11, 2025

Marine algae have excellent phytoconstituents with notable biological activity and bioactive therapeutic benefits, but the anti-oral cancer of Caulerpa lentillifera (C. lentillifera) has not been widely studied. This study aimed to explore anti-cancer properties C. gain insights into possible treatment approaches. The three extracts were prepared using maceration method methanol (CLM), ethanol (CLE), acetone (CLA). chemical composition was investigated. Its metabolite profiles selectively further investigated LC-QTOF MS/MS technique their antioxidative evaluated. cytotoxic effect on KON cells MRC-5 assessed MTT test. Morphological changes apoptosis examined through Hoechst 33,258 AO double staining, while DAPI FDA labeling used observe nucleus cytoplasm. Using a flow cytometer, percentage cell cycle arrest calculated fraction death examined. CLA exhibited higher quantities TPC, TFC, chlorophyll a, b compared CLM CLE. analysis revealed ten major phytochemicals in CLA. activity, CLE demonstrating significantly antioxidant In-vitro, oral sensitivity CLA, CLE, that order. induced ROS-mediated as well disruption mitochondrial membrane potential, concentrations at IC40, IC60, IC80 leading within 24 h. Furthermore, blocked sub-G G0-G1 by all extracts. Notably, impeded colony growth, migration, invasion. increase cellular uptake measured TEER findings showed several functional metabolites, strong anti-tumor properties. According these results, may be utilized treat cancer.

Language: Английский

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Recent developments and challenges in algal protein and peptide extraction strategies, functional and technological properties, bioaccessibility, and commercial applications

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(3)

Published: May 1, 2024

Abstract The burgeoning demand for protein, exacerbated by population growth and recent disruptions in the food supply chain, has prompted a rapid exploration of sustainable protein alternatives. Among these alternatives, algae stand out their environmental benefits, growth, rich content. However, widespread adoption algae‐derived proteins faces significant challenges. These include issues related to harvesting, safety, scalability, high cost, standardization, commercialization, regulatory hurdles. Particularly daunting is efficient extraction algal proteins, as resilient cell walls contain approximately 70% content, with conventional methods accessing only fraction this. Overcoming this challenge necessitates development cost‐effective, scalable, environmentally friendly disruption techniques capable breaking down rigid walls, often laden viscous polysaccharides. Various approaches, including physical, chemical, enzymatic methods, offer potential solutions, albeit varying efficacy depending on specific strain energy transfer efficiency. Moreover, there remains pressing need further research elucidate functional, technological, bioaccessible properties peptides, along exploring diverse commercial applications. Despite obstacles, hold considerable promise source, offering pathway meet escalating nutritional demands growing global population. This review highlights nutritional, functional aspects peptides while underscoring challenges hindering adoption. It emphasizes critical importance establishing trajectory production, playing pivotal role endeavor.

Language: Английский

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Small Biological Fighters Against Cancer: Viruses, Bacteria, Archaea, Fungi, Protozoa, and Microalgae

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 665 - 665

Published: March 8, 2025

Despite the progress made in oncological theranostics, cancer remains a global health problem and leading cause of death worldwide. Multidrug radiation therapy resistance is an important challenge treatment. To overcome this great concern clinical practice, conventional therapies are more used combination with modern approaches to improve quality patients’ lives. In review, we emphasize how small biological entities, such as viruses, bacteria, archaea, fungi, protozoans, microalgae, well their related structural compounds toxins/metabolites/bioactive molecules, can prevent suppress or regulate malignant initiation, progression, metastasis, responses different therapies. All these fighters free-living parasitic nature and, furthermore, protozoans components human animal microbiomes. Recently, polymorphic microbiomes have been recognized new emerging hallmark cancer. Fortunately, there no limit development novel biomedicine. Thus, viral vector-based based on genetically engineered bacteriotherapy, mycotherapy anti-cancer fungal bioactive compounds, use protozoan parasite-derived proteins, nanoarchaeosomes, microalgae-based microrobots oncology, promoting biomimetic biology-inspired strategies maximize diagnostic efficiency, improved life.

Language: Английский

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Current and Prospective Pharmaceutical Use of Algal Bioproducts

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

This chapter explores the diverse applications of algal biocompounds in human health, focusing on dietary, cosmetic, and pharmaceutical uses. Algae, ranging from macroscopic kelp to microscopic single-celled organisms (including cyanobacteria), are a rich source bioactive compounds with potential benefits for health well-being. begins by classifying algae highlighting their historical use as food. It then delves into current prospective biocompounds, dividing discussion three main sections. The first section examines dietary uses food supplements additives, role sources macro- micronutrients, natural colourings, thickeners prebiotics. second external extracts cosmetics, discussing anti-aging, whitening, moisturizing, thickening, photoprotection, antioxidant activity hair care. Finally, third investigates examining antimicrobial, anti-inflammatory activities, hypertension management, direct cancer treatment indirect aids, diagnostic use. aims provide comprehensive overview state research commercial contribute sustainable solutions, enhance cosmetic products, develop novel pharmaceuticals.

Language: Английский

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Ultrasound-Assisted Deep Eutectic Solvent Extraction of Antioxidant and Anti-Colorectal Cancer Proteins from Spirulina Biomass: Process Intensification, Characterization, and Bioactivity Evaluation

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 365 - 365

Published: March 19, 2025

Spirulina, a cyanobacterial biomass, is renowned for its high protein content and bioactive compounds, making it promising candidate health-promoting applications. This study explores the ultrasound-assisted deep eutectic solvent (DES) extraction technique isolating antioxidants anticancer proteins from Spirulina aiming to enhance efficiency preserve bioactivity. The process was optimized using response surface methodology (RSM), varying parameters such as biomass concentration, sonication amplitude, duration. conditions—5% 40% 22-minute extraction—achieved yield of 80.62%, with concentration 442.88 mg/g extract an essential amino acid 39.91%. extracted exhibited remarkable bioactivity, including strong antioxidant properties, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity 0.25 mg GAE/g, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) 0.58 TE/g, ferric reducing power (PFRAP) 9.63 gallic equivalent (GAE)/g. Additionally, displayed selective cytotoxicity against colorectal cancer cell lines, half-maximal inhibitory (IC50) values 10.25 mg/mL Caco-2 15.40 HT-29 cells, while maintaining low toxicity towards normal Vero cells. Apoptosis rates 70.43% in 51.33% cells further confirm potential extract. functional properties protein, foaming capacity (100%), emulsifying (94.05%), digestibility (85.77%), underscore diverse applications food, pharmaceutical, nutraceutical industries. eco-friendly efficient approach aligns sustainable development goals offers viable strategy harnessing Spirulina’s potential.

Language: Английский

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Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1666 - 1666

Published: April 8, 2025

Microalgae are microscopic unicellular organisms that inhabit marine, freshwater, and moist terrestrial ecosystems. The vast number diversity of microalgal species provide a significant reservoir biologically active compounds, highly promising for biomedical applications. Diatoms eukaryotic algae belonging to the class Bacillariophyceae. They possess intricately structured silica-based cell walls, which contain long-chain polyamines play important roles in formation silica. Long-chain uncommon found only produce biosilica. Diatomite, is marine sediment remains silica skeleton diatoms, could be an abundant source biogenic can easily converted particles. This concise review focuses on biofabrication polyamine-based nanosilica from diatoms highlights possibility utilizing diatom biosilica as nanocarrier drug siRNA delivery, bioimaging, bone tissue engineering. challenges may affect production, including environmental stresses climate change, discussed together with prospect increasing diatom-based production desired nanostructures via genetic manipulation.

Language: Английский

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A Dendritic Cell-Recruiting, Antimicrobial Blood Clot Hydrogel for Melanoma Recurrence Prevention and Infected Wound Management

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122776 - 122776

Published: Aug. 30, 2024

Language: Английский

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Nutraceuticals and Functional Foods from Algae: Formulation and Health Benefits

Published: Jan. 1, 2024

Algae are a large and diverse group of autotrophic photosynthetic organisms in the aquatic environment that includes eukaryotic multicellular algae unicellular prokaryotic cyanobacteria. comprise proteins, amino acids, fatty acids (PUFA), vitamins, polysaccharides, pigments, other secondary metabolites. considered as suitable vegetable-like food sources also used supplements for healthy food. The presence bioactive metabolites beneficial compounds some macro- microalgae can be an active ingredient various nutraceuticals healthcare medicines. represent valuable source minerals, antioxidants, natural colorants; hence, whole biomass extracted have feed infant specialist diseased patients. This chapter outlines food, feed, nutrient, nutraceutical uses their health benefits along with special function formulations.

Language: Английский

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