CO-loaded Hemoglobin/EGCG Nanoparticles Functional Coatings for Inflammation Modulation of Vascular Implants DOI Creative Commons

Sui Wu,

Ruifang Dong,

Yinhong Xie

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Abstract During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and inflammatory is accompanied oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing antiproliferative properties. In this study, hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle-containing coating on stainless steel was prepared for CO loading modulation. Inspired strong coordination ability with CO, hemoglobin nanoparticle first encapsulated into EGCG metal-phenolic networks. A polydopamine (PDA) linking layer then coated 316 steel, hemoglobin/EGCG nanoparticles were loaded subsequent PDA deposition. It showed that maximum release amount 17.0 nmol/cm2 in 48 h. vitro evaluations conducted a simulated environment revealed coating, which released from nanoparticles, effectively mitigated lipopolysaccharide-induced response macrophages. Specifically, it decreased expression tumor necrosis factor-α, increased interleukin-10, suppressed polarization macrophages toward M1 phenotype reduced intracellular reactive oxygen species (ROS). Furthermore, under stress conditions, apoptosis endothelial cells induced down-regulated ROS levels. vivo results further confirmed its capabilities, macrophage-mediated responses modulated

Language: Английский

Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing DOI
Yiwen Zhang,

Zixuan Tang,

Liyun Chen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 961 - 981

Published: Jan. 1, 2025

Language: Английский

Citations

2
Antimicrobial Phenolic Materials: From Assembly to Function DOI Creative Commons
Wanjun Xu, Zhixing Lin, Christina Cortez‐Jugo

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

Citations

2
Recent advances of copper-based metal phenolic networks in biomedical applications DOI
Ying Zhang,

Fengxiang Hao,

Yingyu Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114163 - 114163

Published: Aug. 14, 2024

Language: Английский

Citations

10
Recent advances in nanomaterials and their mechanisms for infected wounds management DOI Creative Commons
Jianping Zhu, Fan Xia,

Shuaifei Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

Citations

1
Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

Citations

8
Cohesion Regulation of Polyphenol Cross‐Linked Hydrogel Adhesives: From Intrinsic Cross‐Link to Designs of Temporal Responsiveness DOI
Xing Qi, Zhen Li, Xianliang Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Polyphenol hydrogels have found widespread application in wound healing, bone repair, drug delivery, and biosensors due to their robust wet adhesion, high ductility, excellent self‐healing ability. However, these often exhibit low intrinsic cohesion, which limits overall adhesive strength. Enhancing cohesion is critical for improving both the adhesion mechanical properties of hydrogels, thereby expanding utility biomedical fields. This review begins by exploring strategies enhance polyphenol hydrogel adhesives, detailing modifications that act individually or synergistically. The importance temporally regulating emphasized accommodate various applications environmental conditions. Finally, this paper discusses remaining challenges regulation outlines prospects future research. It hoped comprehensive will provide new insights into development advanced polyphenolic adhesives contribute design “smart adhesives” increasingly complex needs applications.

Language: Английский

Citations

6
Exploring Caffeic Acid and Lignosulfonate as Key Phenolic Ligands for Metal-Phenolic Network Assembly DOI Creative Commons
Daniela Tomasetig, Chenyu Wang, Nikolaus Hondl

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(18), P. 20444 - 20453

Published: April 26, 2024

Films formed by metals and phenols through a coordinative interaction have been extensively studied in previous years. We report the successful formation of MPN films from phenolic compounds caffeic acid lignosulfonate using Fe3+ ions for complexation. The likewise examined p-coumaryl alcohol showed some film tendency, while coniferyl sinapyl alcohol, no buildup could be observed. These newly were compared to tannic acid-Fe3+ as reference. Film growth degradation tracked UV–vis absorption spectroscopy. degradable under different conditions such alkaline environments or presence strong chelator. Small hollow capsules with diameter 3 μm thicknesses nanometer range produced. Additionally, prepared varying colors levels wettability. By utilizing films' coating properties, we successfully dyed human hair various colors.

Language: Английский

Citations

4
Optimization of the Peroxidase Enzyme-Mimetic Capacity of Manganese-Tannic acid Complexes DOI
Man Li, Hafez Jafari, Oseweuba Valentine Okoro

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136109 - 136109

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stable Antifouling and Antibacterial Coating Based on Assembly of Copper-Phenolic Networks DOI

Adel S. Imbia,

Artjima Ounkaew, Hongbo Zeng

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm formation on medical devices has become a worldwide issue arising from its resistance to bactericidal agents and presenting challenges eradicating biofouling adhesion, especially in biological fluids. Metal-phenolic networks have been demonstrated as versatile efficient strategy prevent biofilm by endowing with prolonged antifouling antibacterial activities one-step surface modification. In this study, we report simple environmentally friendly method using coordination chemistry between copper ions (Cu2+) dopamine-containing copolymer fabricate metal-phenolic network-based coatings. The phenolic groups also imparted the adhesion of glycopolymer-containing dopamine residues inorganic organic substrates, resulting dual surfaces. 2-gluconamidoethyl methacrylamide monomer (GAEMA) was first copolymerized (DMA) free-radical polymerization process. (GAEMA-DMA), denoted GADMA, then mixed process form GADMA-Cu coating. coating hydrophilic significantly reduced water contact angle (WCA) adsorption bovine serum albumin protein even after incubation solution for 30 h. Moreover, exhibited strong activity against Escherichia coli Staphylococcus aureus biocompatible 99% cell viability toward normal human fibroblast (HDFa) cells. Thus, our shows great potential application devices.

Language: Английский

Citations

0
Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing DOI
Jing Feng, Zifei Wang, Xiyu Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The management of chronic infected wounds remains a significant clinical challenge, largely due to the deficiency optimal wound dressings with adequate mechanical strength, appropriate adhesiveness, and efficient sustainable antibacterial, reactive oxygen species (ROS) scavenging, pro-angiogenesis, immunomodulation properties. To address such dilemma, we employed simple facile strategy utilize resveratrol (RSV) as functional component mediate hydrogel gelation in this study. structure obtained was supported by multibond network, which not only endowed resultant product superior strength moderate adhesiveness but also effectively prolonged bioavailability RSV. This successfully integrated entire system ROS Subsequent vivo evidence has verified that material capable accelerate healing wounds. underlying mechanism can be explained is propelling macrophage polarization from M1 M2 phenotype through modulating PI3K/AKT signaling pathway activate nuclear factor erythroid 2-related 2 (Nrf2) well maintaining mitochondrial membrane potential level normal state under excessive inflammatory oxidative stimulus. In summary, multifunctional dressing provides feasible way promote RSV, conducive for preparing promising candidate healing. What more important, it beneficial reveal correlative mechanisms establish advanced therapeutic platform targeting other complex infection microenvironment.

Language: Английский

Citations

0