Nanotechnology for the Diagnosis and Treatment of Liver Cancer DOI Creative Commons
Yong Cai, Weiwei Wang,

Qinlian Jiao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13805 - 13821

Published: Dec. 1, 2024

Liver cancer has become a major global health challenge due to its high incidence, rate of late diagnosis and limited treatment options. Although there are many clinical treatments available for liver cancer, the cure is still very low, now researchers have begun explore new aspects treatment, nanotechnology shown great potential improving diagnostic accuracy therapeutic efficacy therefore promising option. In diagnosis, nanomaterials such as gold nanoparticles, magnetic silver nanoparticles can realize highly sensitive specific detection biomarkers, supporting real-time monitoring disease process. terms nanocarriers precise targeted delivery drugs, improve bioavailability drugs reduce systemic toxic side effects. addition, advanced technologies nanoparticle-based photothermal therapy photodynamic provide innovative solutions overcome drug resistance local tumor ablation. Therefore, in this paper, we will introduce hepatocellular carcinoma marker detection, delivery, synergistic PDT/CDT therapy.

Language: Английский

Advances in nanotechnology for targeting cancer-associated fibroblasts: A review of multi-strategy drug delivery and preclinical insights DOI Creative Commons

Zhongsong Zhang,

Yujie Tang,

Dan Luo

et al.

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 1, 2025

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting growth, immune evasion, and metastasis. Recently, drug delivery systems targeting CAFs have emerged as promising long-term effective approach to cancer treatment. Advances nanotechnology, particular, led development of nanomedicine designed specifically target CAFs, offering new possibilities for precise personalized therapies. This article reviews recent progress using nanocarriers that CAFs. Additionally, we explore potential combining multiple therapies, such chemotherapy immunotherapy, with enhance efficacy overcome resistance. Although many preclinical studies show promise, clinical application still faces considerable challenges, especially terms penetration large-scale production. Therefore, this review aims provide fresh perspective on CAF-targeted highlight future research directions applications.

Language: Английский

Citations

0
Cancer cell membrane-coated sulindac-ortho ester nanoprodrug for inhibiting COX-2 expression and chemo-photothermal synergistic antitumor therapy DOI
J Zhang, Qiang Yang, Yiming Zhang

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125460 - 125460

Published: March 1, 2025

Language: Английский

Citations

0
Factors Contributing to the High Malignancy Level of Cholangiocarcinoma and Its Epidemiology: Literature Review and Data DOI Creative Commons
Xuan Li, Renchu Guan, Shuangquan Zhang

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 351 - 351

Published: March 28, 2025

CCA is a highly desmoplastic malignant cancer and the second most common primary liver malignancy after hepatocellular carcinoma (HCC), accounting for approximately 15% of all tumors. has poor prognosis, with an average five-year survival rate 9%, which lower than that pancreatic cancer. Although considerable efforts have been invested into genomics, epigenetics, risk factors, very little known about what might key causes high level CCA. In this review, we analyze incidence mortality in different regions based on data from 1994 to 2022 obtained International Agency Research Cancer (IARC), discuss current status treatment disease, focus be main factors contributing CCA: alkalosis caused by Fenton reaction, hypoxia, TIME. The review includes studies published 1979 2024, aiming provide updated synthesis basic early classical theoretical knowledge By revealing epidemiological characteristics CCA, potential mechanisms malignancy, challenges treatment, aims new directions future research, promote development personalized strategies, facilitate deeper understanding more effective management worldwide.

Language: Английский

Citations

0
The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations DOI Creative Commons

Bowen Zhang,

Ruiqun Qi

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Heat shock protein 70 (HSP70) is a highly conserved molecular chaperone that plays core role in assisting folding and maintaining cellular homeostasis. In recent years, studies have revealed HSP70 has dual functions immune regulation: on the one hand, it enhances responses by activating non-specific immunity (such as Toll-like receptor 2/4 (TLR2/4) signaling pathways) specific cross-presentation of antigens, T helper 1 (Th1)/T 17 (Th17) differentiation); other inhibits excessive reactions inducing differentiation regulatory cells (Treg) promoting secretion anti-inflammatory factors [such interleukin-10 (IL-10)]. cancer, duality also very prominent: can drive tumor progression through pathways such inhibiting apoptosis, angiogenesis, metastasis, inhibit growth immunogenic cell death (ICD), enhancing antigen presentation, natural killer (NK) activity. This review aims to systematically analyze HSP70, focusing its mechanisms “double-edged sword” nature immunotherapy innovative targeted strategies, well providing theoretical basis research directions for precision medicine treatment strategies related diseases.

Language: Английский

Citations

0
Promising New Anti‐TIGIT Agents: Stealthy Allies in Cancer Immunotherapy DOI Creative Commons
G. Srikanth,

Durga Prasad Beda,

Ashish Ranjan Dwivedi

et al.

Clinical and Translational Science, Journal Year: 2025, Volume and Issue: 18(4)

Published: April 1, 2025

ABSTRACT TIGIT (T cell immunoreceptor with immunoglobulin and tyrosine‐based inhibitory motif (ITIM) domain), Vstm3, VSIG9, are newly recognized immunological checkpoints. They prominently expressed on CD4+ CD8+ T cells, tumor‐infiltrating lymphocytes (TILs), natural killer (NK) regulatory cells (Tregs). The (TIGIT) protein is crucial for immune modulation since it diminishes NK populations hinders activity in cancer patients experimental models. CD155, the principal ligand of humans, has been as a pivotal target immunotherapy owing to its interaction TIGIT. CD155 linked efficacy anti‐programmed death 1 (PD‐1) therapy, even without expression, underscoring importance checkpoint suppression. Anti‐TIGIT medicines, either independently or conjunction anti‐PD‐1 treatments, have demonstrated potential augmenting responses malignancies. This review examines structural functional characteristics protein, new developments anti‐TIGIT drugs, their prospective use immunotherapy.

Language: Английский

Citations

0
Exosome-based immunotherapy in hepatocellular carcinoma DOI Creative Commons
Zhihong Liu, Guowei Wang, Zhi Li

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Language: Английский

Citations

0
Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance DOI Creative Commons
Wenjun Meng, Li Huang,

Jia‐Min Guo

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1549 - 1549

Published: Dec. 3, 2024

Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve efficacy reduce toxic side effects. This review examines impact TME on recent advances in nanomedicine overcome this challenge. Characteristics such as hypoxia, acidity, high interstitial pressure significantly effectiveness chemotherapy radiotherapy, leading increased cells. Then, summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, multifunctional nanosystems that enable targeted release improved penetration accumulation tumors. combining with therapeutic strategies, offers a novel perspective by focusing design nanocarriers interact TME, dimension often overlooked similar reviews. We highlight dual role modulation, emphasize their resistance, look at future research directions.

Language: Английский

Citations

3
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy DOI
Sankha Bhattacharya, Paul Beninger

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(10), P. 727 - 741

Published: March 1, 2024

Abstract: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within embryonic landscape nanotechnology. Nanoparticles, pivotal in treatment, are systematically examined their diverse physicochemical structures, categorized organic (lipid-based, protein-based, and polymer-assisted) inorganic (carbon-based metal) varieties. A significant focus is placed on CMNPs, which serve an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. manuscript accurately explores advantages challenges various membranes, including those derived from cells, red blood platelets, stem white cells. Importance roles enhancing precision, immune system circumvention, targeted recognition. Detailed insights into crafting CMNPs provided, elucidating membrane extraction fusion techniques, such sonication, extrusion, co-extrusion, microfluidic electroporation. Maintaining integrity during benefits coating techniques augmenting biocompatibility underscored. comprehensive resource consolidates latest advancements delivery, positioning itself at forefront nanotechnology biomedicine research. Encapsulating methodologies like electrospray, chemical conjugation, this showcases expanding toolbox available to researchers dynamic field. Focusing unique characteristics multifaceted applications biomedical research, particularly tumour therapy. It provides indepth analysis stability, evasion capabilities, increased payload capacity, retained biological functionality. The outlines current future prospects chemotherapy, photothermal photodynamic therapy, immunotherapy, gene therapeutic methods. concludes by highlighting transformative potential reshaping treatment.

Language: Английский

Citations

2
Oncomatrix: Molecular Composition and Biomechanical Properties of the Extracellular Matrix in Human Tumors DOI Creative Commons
Ilya Klabukov, Anna N. Smirnova, A. O. Yakimova

et al.

Journal of Molecular Pathology, Journal Year: 2024, Volume and Issue: 5(4), P. 437 - 453

Published: Oct. 5, 2024

The extracellular matrix is an organized three-dimensional network of protein-based molecules and other macromolecules that provide structural biochemical support to tissues. Depending on its properties, the influences cell adhesion signal transduction and, in general, can influence differentiation proliferation through specific mechanisms chemical mechanical sensing. development body tissues during ontogenesis accompanied by changes not only cells but also composition properties matrix. Similarly, tumor carcinogenesis a continuous change cells, called ‘oncomatrix’, as matures, from primary focus stage metastasis. In this paper, characteristics are considered, well evolution patterns be used biomarkers oncological diseases potential targets for promising anti-tumor therapies.

Language: Английский

Citations

2
Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway DOI Creative Commons
Yushan Ye, Fan Wu, Bowen Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Background: Cancer-associated fibroblasts (CAFs) play a critical role in tumor progression. In this study, we explored the influence of exosomal piR-35462 (piR-35462) derived from CAFs on oral squamous cell carcinoma (OSCC) Methods: and normal (NFs) were obtained patients-derived samples OSCC adjacent tissues. Exosomes extracted NFs confirmed piRNAs was identified screened. CCK8 assays, EdU Transwell assays performed to assess proliferation metastasis. A nude mouse model established impact Results: CAFs-derived exosomes showed enhanced expression promoted proliferation, migration invasion. Additionally, elevated tissues correlates with poor prognosis. Mechanistically, increased fat mass obesity-associated protein (FTO) cells. By inhibiting N6-methyladenosine (m6A) RNA methylation, overexpression FTO further enhances stability levels Twist1 mRNA, thereby contributing epithelial-mesenchymal transition (EMT) vivo xenograft also same results. Conclusion: The achieved outcomes elucidate that can deliver containing cells promote progression via FTO/Twist mediated EMT pathways, could represent promising therapeutic target for OSCC.

Language: Английский

Citations

1