International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 13805 - 13821
Published: Dec. 1, 2024
Liver
cancer
has
become
a
major
global
health
challenge
due
to
its
high
incidence,
rate
of
late
diagnosis
and
limited
treatment
options.
Although
there
are
many
clinical
treatments
available
for
liver
cancer,
the
cure
is
still
very
low,
now
researchers
have
begun
explore
new
aspects
treatment,
nanotechnology
shown
great
potential
improving
diagnostic
accuracy
therapeutic
efficacy
therefore
promising
option.
In
diagnosis,
nanomaterials
such
as
gold
nanoparticles,
magnetic
silver
nanoparticles
can
realize
highly
sensitive
specific
detection
biomarkers,
supporting
real-time
monitoring
disease
process.
terms
nanocarriers
precise
targeted
delivery
drugs,
improve
bioavailability
drugs
reduce
systemic
toxic
side
effects.
addition,
advanced
technologies
nanoparticle-based
photothermal
therapy
photodynamic
provide
innovative
solutions
overcome
drug
resistance
local
tumor
ablation.
Therefore,
in
this
paper,
we
will
introduce
hepatocellular
carcinoma
marker
detection,
delivery,
synergistic
PDT/CDT
therapy.
Human Molecular Genetics,
Journal Year:
2024,
Volume and Issue:
33(13), P. 1186 - 1193
Published: March 27, 2024
Abstract
Melanoma,
renowned
for
its
aggressive
behavior
and
resistance
to
conventional
treatments,
stands
as
a
formidable
challenge
in
the
oncology
landscape.
The
dynamic
complex
interplay
between
cancer
cells
tumor
microenvironment
has
gained
significant
attention,
revealing
Melanoma-Associated
Fibroblasts
(MAFs)
central
players
disease
progression.
heterogeneity
of
MAFs
endows
them
with
dual
role
melanoma.
This
exhaustive
review
seeks
not
only
shed
light
on
multifaceted
roles
orchestrating
tumor-promoting
inflammation
but
also
explore
their
involvement
antitumor
immunity.
By
unraveling
novel
mechanisms
underlying
MAF
functions,
this
aims
provide
comprehensive
understanding
impact
melanoma
development.
Additionally,
it
delves
into
potential
leveraging
innovative
immunotherapeutic
strategies,
offering
new
avenues
enhancing
treatment
outcomes
challenging
realm
therapeutics.
Current Genomics,
Journal Year:
2024,
Volume and Issue:
25(5), P. 390 - 411
Published: June 13, 2024
Targeted
therapies
have
improved
the
clinical
outcomes
of
most
patients
with
cancer.
However,
heterogeneity
gastric
cancer
remains
a
major
hurdle
for
precision
treatment.
Further
investigations
into
tumor
microenvironment
are
required
to
resolve
these
problems.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9502 - 9502
Published: Aug. 31, 2024
Lung
adenocarcinoma
(LUAD)
poses
significant
challenges
due
to
its
complex
biological
characteristics
and
high
recurrence
rate.
The
rate
of
LUAD
is
closely
associated
with
cellular
dormancy,
which
enhances
resistance
chemotherapy
evasion
immune
cell
destruction.
Using
single-cell
RNA
sequencing
(scRNA-seq)
data
from
patients,
we
categorized
the
cells
into
two
subclusters:
dormant
active
cells.
Utilizing
high-density
Weighted
Gene
Co-expression
Network
Analysis
(hdWGCNA)
pseudo-time
trajectory,
aberrant
expression
genes
involved
in
protein
O-glycosylation
was
detected
cells,
suggesting
a
crucial
role
for
maintaining
state.
Intercellular
communication
analysis
highlighted
interaction
between
fibroblasts
where
Insulin-like
Growth
Factor
(IGF)
signaling
pathway
regulated
by
crucial.
By
employing
Set
Variation
(GSVA)
machine
learning,
risk
score
model
developed
using
hub
genes,
showed
accuracy
determining
prognosis.
also
demonstrated
robust
performance
on
training
dataset
excellent
predictive
capability,
providing
reliable
basis
predicting
patient
clinical
outcomes.
group
higher
exhibited
propensity
adverse
outcomes
tumor
microenvironment
(TME)
mutational
burden
(TMB).
Additionally,
50%
inhibitory
concentration
(IC50)
values
variations
among
different
groups.
In
vitro
experiments
that
EFNB2,
PTTG1IP,
TNFRSF11A
were
upregulated
contributed
greatly
diagnosis
LUAD.
conclusion,
this
study
dormancy
state
tumors
prognosis
patients.
Translational Cancer Research,
Journal Year:
2024,
Volume and Issue:
13(10), P. 5600 - 5615
Published: Oct. 1, 2024
Breast
cancer
(BRCA)
is
a
prevalent
and
aggressive
disease.
Despite
various
treatments
being
applied,
significant
number
of
patients
continue
to
experience
unfavorable
prognoses.
Accurate
prognosis
prediction
in
BRCA
crucial
for
tailoring
individualized
treatment
plans
improving
patient
outcomes.
Recent
studies
have
highlighted
the
significance
immune
cell
infiltration
tumor
microenvironment
(TME),
but
predicting
survival
remains
challenging
due
heterogeneity
BRCA.
The
aim
this
study
was
thus
produce
an
signature-based
framework
capable
with
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 13805 - 13821
Published: Dec. 1, 2024
Liver
cancer
has
become
a
major
global
health
challenge
due
to
its
high
incidence,
rate
of
late
diagnosis
and
limited
treatment
options.
Although
there
are
many
clinical
treatments
available
for
liver
cancer,
the
cure
is
still
very
low,
now
researchers
have
begun
explore
new
aspects
treatment,
nanotechnology
shown
great
potential
improving
diagnostic
accuracy
therapeutic
efficacy
therefore
promising
option.
In
diagnosis,
nanomaterials
such
as
gold
nanoparticles,
magnetic
silver
nanoparticles
can
realize
highly
sensitive
specific
detection
biomarkers,
supporting
real-time
monitoring
disease
process.
terms
nanocarriers
precise
targeted
delivery
drugs,
improve
bioavailability
drugs
reduce
systemic
toxic
side
effects.
addition,
advanced
technologies
nanoparticle-based
photothermal
therapy
photodynamic
provide
innovative
solutions
overcome
drug
resistance
local
tumor
ablation.
Therefore,
in
this
paper,
we
will
introduce
hepatocellular
carcinoma
marker
detection,
delivery,
synergistic
PDT/CDT
therapy.
