Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 2, 2024
Abstract Despite recent advances in immunotherapy, its efficacy remains constrained by the absence of immune coordination. Especially, interplay between tumor‐draining lymph nodes (TDLNs) and tumors is frequently disregarded. Here, a self‐adjuvanting hydrogel capable eliciting powerful sustained response developed. Briefly, engineered arabinose bacteria (ARB) expressing IL‐15 mannose‐modified hollow mesoporous Prussian blue nanoparticles (NPs) loaded with vitamin E (Man/HMPB(VE), MHV) are mixed (AraGel), forming system designated as AraGel@ARB/MHV (AAM). Employing mild photothermal therapy mediated MHV, immunogenic cell death (ICD) triggers release tumor‐associated antigens. Subsequently, Man‐modified NPs target TDLNs VE, which suppresses checkpoint Src homology region 2 domain‐containing phosphatase‐1 (SHP1) dendritic cells, thereby enhancing antigen presentation T activation. Meanwhile, expression ARB(IL‐15) induced AraGel degradation enables ARB to serve an enhanced adjuvant manner, working synergistically ICD TDLN reprogramming promote cytotoxic lymphocytes The efficiently tumor growth prolonged immunotherapy orchestrated manner. Overall, holds great potential for cancer immunotherapy.
Language: Английский