Self‐Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor‐Draining Lymph Nodes to Enhance Cancer Immunotherapy DOI
Xiuhua Pan, Feiyang Liu,

Ruixin Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Despite recent advances in immunotherapy, its efficacy remains constrained by the absence of immune coordination. Especially, interplay between tumor‐draining lymph nodes (TDLNs) and tumors is frequently disregarded. Here, a self‐adjuvanting hydrogel capable eliciting powerful sustained response developed. Briefly, engineered arabinose bacteria (ARB) expressing IL‐15 mannose‐modified hollow mesoporous Prussian blue nanoparticles (NPs) loaded with vitamin E (Man/HMPB(VE), MHV) are mixed (AraGel), forming system designated as AraGel@ARB/MHV (AAM). Employing mild photothermal therapy mediated MHV, immunogenic cell death (ICD) triggers release tumor‐associated antigens. Subsequently, Man‐modified NPs target TDLNs VE, which suppresses checkpoint Src homology region 2 domain‐containing phosphatase‐1 (SHP1) dendritic cells, thereby enhancing antigen presentation T activation. Meanwhile, expression ARB(IL‐15) induced AraGel degradation enables ARB to serve an enhanced adjuvant manner, working synergistically ICD TDLN reprogramming promote cytotoxic lymphocytes The efficiently tumor growth prolonged immunotherapy orchestrated manner. Overall, holds great potential for cancer immunotherapy.

Language: Английский

Characteristics of the Immune Microenvironment and Progress in Immunotherapy for Triple-Negative Breast Cancer DOI

书韬 贾

World Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(01), P. 24 - 38

Published: Jan. 1, 2025

Language: Английский

Citations

0
Real-time ROS monitoring-guided tumor electrodynamic therapy using a metal microneedle array system DOI
Xiaoxue Xie, Jing Liu, Zhengjie Liu

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102731 - 102731

Published: April 4, 2025

Language: Английский

Citations

0
A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade DOI Creative Commons
Yujun Bao, Guanghao Li,

Siqi Li

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346

Published: Nov. 16, 2024

Language: Английский

Citations

1
Self‐Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor‐Draining Lymph Nodes to Enhance Cancer Immunotherapy DOI
Xiuhua Pan, Feiyang Liu,

Ruixin Kang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Despite recent advances in immunotherapy, its efficacy remains constrained by the absence of immune coordination. Especially, interplay between tumor‐draining lymph nodes (TDLNs) and tumors is frequently disregarded. Here, a self‐adjuvanting hydrogel capable eliciting powerful sustained response developed. Briefly, engineered arabinose bacteria (ARB) expressing IL‐15 mannose‐modified hollow mesoporous Prussian blue nanoparticles (NPs) loaded with vitamin E (Man/HMPB(VE), MHV) are mixed (AraGel), forming system designated as AraGel@ARB/MHV (AAM). Employing mild photothermal therapy mediated MHV, immunogenic cell death (ICD) triggers release tumor‐associated antigens. Subsequently, Man‐modified NPs target TDLNs VE, which suppresses checkpoint Src homology region 2 domain‐containing phosphatase‐1 (SHP1) dendritic cells, thereby enhancing antigen presentation T activation. Meanwhile, expression ARB(IL‐15) induced AraGel degradation enables ARB to serve an enhanced adjuvant manner, working synergistically ICD TDLN reprogramming promote cytotoxic lymphocytes The efficiently tumor growth prolonged immunotherapy orchestrated manner. Overall, holds great potential for cancer immunotherapy.

Language: Английский

Citations

0