Effective Hydrogel Vascular Patch Dual‐Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm DOI Open Access
Du Chen,

Tiantian Song,

Yi Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Endovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic (AAA) clinic, but remains patient's body after surgery, continuing to pose risk progression. Cycloastragenol (CAG) is proven be an effective anti-AAA drug, and its vascular protective effects can further improved when hydrophobic CAG encapsulated into nano-sized formulations enhance bioavailability. In this context, study developed extravascular patch hydrogel loaded with nanostructured lipid carriers hydrophilic drug doxycycline hydrochloride (DOX). The delivered onto mouse aortas promote local permeation hydrophilic/hydrophobic drugs at vessel sites provide protection against AAA injury induced by elastase. This introduces novel promising approach for treatment, which serve as supplementary strategy EVAR surgery.

Language: Английский

Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis DOI
Huilin Ma, Y. Li, Huan Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139114 - 139114

Published: Jan. 2, 2025

Language: Английский

Citations

0
Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway DOI Creative Commons
Jun Zhang, Xing Zhu, Yong Li

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 17, 2025

Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial the development of sepsis-induced coagulopathy (SIC). The role Parthenolide (PTL) regulating SIC by protecting VECs remains unclear. study utilized septic rats and lipopolysaccharide (LPS)-stimulated simulate model observe therapeutic effects PTL. Additionally, nanotechnology was employed produce Nano-PTL (N-PTL), whether it has advantages over PTL treating SIC. been shown mitigate lung injury rats, significantly reduce tumor necrosis factor-α (TNF-α) levels, increase survival rates. treatment also enhances function, augments vascular cell (VEC) reduces mitochondrial fragmentation, increases both oxygen consumption rate (OCR) membrane potential (MMP), while inhibiting reactive species (ROS) production. By increasing BRD4/BCL-xL prevent mitochondrial-mediated apoptosis VECs, improve VEC consequently ameliorate nanotechnology-synthesized N-PTL further protective on function. This clarifies mechanisms SIC, offering new strategies directions for sepsis.

Language: Английский

Citations

0
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development DOI Creative Commons

Elena Gardey,

Johannes C. Brendel, Andreas Stallmach

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

Citations

0
Colon-targeted dual-coating MOF nanoparticles for the delivery of curcumin with anti-inflammatory properties in the treatment of ulcerative colitis DOI

Haoqiang Lei,

Yipeng Liu, Jing Li

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114545 - 114545

Published: Feb. 1, 2025

Language: Английский

Citations

0
Toxicity and Oxidative Stress Biomarkers in the Organs of Mice Treated with Mesoporous Polydopamine Nanoparticles Modified with Iron and Coated with Cancer Cell Membrane DOI Creative Commons
Marta Napierała, Bartosz F. Grześkowiak, Magdalena J. Bigaj-Józefowska

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12053 - 12078

Published: Nov. 1, 2024

Polydopamine nanoparticles (PDA NPs) have great potential in medicine. Their applications being widely investigated cancer therapy, imaging, chemotherapy, photodynamic therapy (PDT), photothermal (PTT), and tissue repair. The aim of our study was to assess the vivo toxicity changes oxidative stress biomarkers organs animals treated with mesoporous PDA NPs modified iron (MPDAFe NPs), coated cell membrane loaded doxorubicin (DOX), subsequently subjected PTT.

Language: Английский

Citations

2
ROS-responsive quercetin-based polydopamine nanoparticles for targeting ischemic stroke by attenuating oxidative stress and neuroinflammation DOI

Chuyao Jian,

Yigen Hong,

Hongsheng Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125087 - 125087

Published: Dec. 14, 2024

Language: Английский

Citations

1
Effective Hydrogel Vascular Patch Dual‐Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm DOI Open Access
Du Chen,

Tiantian Song,

Yi Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Endovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic (AAA) clinic, but remains patient's body after surgery, continuing to pose risk progression. Cycloastragenol (CAG) is proven be an effective anti-AAA drug, and its vascular protective effects can further improved when hydrophobic CAG encapsulated into nano-sized formulations enhance bioavailability. In this context, study developed extravascular patch hydrogel loaded with nanostructured lipid carriers hydrophilic drug doxycycline hydrochloride (DOX). The delivered onto mouse aortas promote local permeation hydrophilic/hydrophobic drugs at vessel sites provide protection against AAA injury induced by elastase. This introduces novel promising approach for treatment, which serve as supplementary strategy EVAR surgery.

Language: Английский

Citations

0