International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 6829 - 6843
Published: July 1, 2024
Background:
With
the
rapid
development
of
nanotechnology,
constructing
a
multifunctional
nanoplatform
that
can
deliver
various
therapeutic
agents
in
different
departments
and
respond
to
endogenous/exogenous
stimuli
for
multimodal
synergistic
cancer
therapy
remains
major
challenge
address
inherent
limitations
chemotherapy.
Methods:
Herein,
we
synthesized
hollow
mesoporous
Prussian
Blue@zinc
phosphate
nanoparticles
load
glucose
oxidase
(GOx)
DOX
(designed
as
HMPB-GOx@ZnP-DOX
NPs)
non-identical
pore
structures
their
HMPB
core
ZnP
shell,
respectively,
photothermally
augmented
chemo-starvation
therapy.
Results:
The
shell
coated
on
core,
addition
providing
space
chemotherapy,
could
also
serve
gatekeeper
protect
GOx
from
premature
leakage
inactivation
before
reaching
tumor
site
because
its
degradation
characteristics
under
mild
acidic
conditions.
Moreover,
loaded
initiate
starvation
by
catalyzing
oxidation
while
causing
an
upgradation
acidity
H
2
O
levels,
which
be
used
forceful
endogenous
trigger
smart
delivery
systems
applications.
decrease
pH
improve
pH-sensitivity
drug
release,
supplied
decomposing
through
catalase-like
activity
HMPBs,
is
beneficial
relieving
adverse
conditions
anti-tumor
activity.
In
addition,
inner
acts
photothermal
agent
generated
hyperthermia
upon
laser
irradiation
external
stimulus
further
promote
release
enzymatic
activities
GOx,
thereby
enabling
synergetic
enhanced
effect.
Importantly,
these
results
indicate
NPs
effectively
inhibit
growth
80.31%
exhibit
no
obvious
systemic
toxicity
mice.
Conclusion:
employed
potential
theranostic
incorporate
multiple
modes
efficiently
tumors.
Keywords:
Blue,
oxidase,
co-delivery
system,
therapy,
chemotherapy
Molecules,
Journal Year:
2024,
Volume and Issue:
29(8), P. 1848 - 1848
Published: April 18, 2024
In
recent
years,
the
frequency
of
strokes
has
been
on
rise
year
by
and
become
second
leading
cause
death
around
world,
which
is
characterized
a
high
mortality
rate,
recurrence
disability
rate.
Ischemic
account
for
large
percentage
strokes.
A
reperfusion
injury
in
ischemic
complex
cascade
oxidative
stress,
neuroinflammation,
immune
infiltration,
mitochondrial
damage.
Conventional
treatments
are
ineffective,
presence
blood–brain
barrier
(BBB)
leads
to
inefficient
drug
delivery
utilization,
so
researchers
turning
their
attention
nano-drug
systems.
Functionalized
systems
have
widely
studied
applied
study
cerebral
diseases
due
favorable
biocompatibility,
efficiency,
strong
specificity,
specific
targeting
ability.
this
paper,
we
briefly
describe
pathological
process
injuries
focus
therapeutic
research
progress
strokes,
aiming
provide
certain
references
understand
(NDDSs).
Technology in Cancer Research & Treatment,
Journal Year:
2024,
Volume and Issue:
23
Published: Jan. 1, 2024
Single
biofilm
biomimetic
nanodrug
delivery
systems
based
on
single
cell
membranes,
such
as
erythrocytes
and
cancer
cells,
have
immune
evasion
ability,
good
biocompatibility,
prolonged
blood
circulation,
high
tumor
targeting.
Because
of
the
different
characteristics
functions
each
membrane,
more
researchers
are
using
various
hybrid
membranes
according
to
their
specific
needs.
This
review
focuses
several
types
nanodrug-delivery
composite
biofilms
looks
forward
challenges
possible
development
directions
provide
reference
ideas
for
future
research.
Journal of Nanoparticle Research,
Journal Year:
2024,
Volume and Issue:
26(8)
Published: Aug. 1, 2024
Abstract
Glioblastoma
(GBM),
the
most
prevalent
primary
brain
tumor
in
adults,
remains
highly
challenging
due
to
its
invasive
nature,
limited
treatment
effectiveness,
and
short
median
survival
durations.
Standard
of
care
includes
surgery,
radiation,
chemotherapy,
treating
fields;
however,
there
has
been
little
improvement
rates.
Biomimetic
nanoparticles
(NPs),
coated
with
cell
membranes
endogenous
components,
have
immense
potential
for
improving
chemotherapy
GBM,
by
imitating
cellular
architecture
eluding
immune
clearance.
With
more
individualized
efficient
drug
delivery,
immunotherapeutic
approaches
biomimetic
NPs
may
increase
patient
This
article
summarizes
main
research
on
GBM
therapy,
focusing
classification,
mechanisms,
advantages,
challenges,
along
advancements
development
vaccines.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 26, 2024
Angiogenesis
is
the
formation
of
blood
vessels
from
existing
vasculature,
which
important
in
tumor
growth
where
metastatic
spread,
cancer
cells
depends
on
an
adequate
supply
oxygen
and
nutrients
removal
waste
products.
Targeting
angiogenesis
has
emerged
as
a
promising
therapeutic
strategy
for
treatment.
This
study
presents
synthesis
evaluation
novel
Ag-CeO2-ZnO
(AgCZ)
nanocomposite
designed
to
specifically
inhibit
effective
therapy.
The
was
synthesized
via
glycine-assisted
combustion
method,
its
physicochemical
properties
were
meticulously
characterized
using
advanced
analytical
techniques.
anti-angiogenesis
potential
AgCZ
vigorously
explored
through
assortment
vitro
investigations,
with
particular
interest
inhibiting
agents
like
vascular
endothelial
factor
(VEGF).
In
silico
data
molecular
docking
studies
instrumental
elucidating
nanocomposite's
primary
reported
mechanism
action,
i.e.,
strong
VEGF
target
bond.
Notably,
had
selective
cytotoxicity
different
types
no
sign
serious
influence
onto
normal
cells,
reflecting
great
promise
targeted
Not
importantly,
implemented
measure
anti-angiogenic
well
anti-tumor
effect
biological
models
additionally.
Our
highlights
emerging
developments
medicine
draws
possible
future
paths.
use
composite
nanoparticle
one
anticancer
drug
alternative
conventional
appears
be
safer
more
effectual,
but
further
research
needed
overcome
current
limitations
clinical
translation.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 6829 - 6843
Published: July 1, 2024
Background:
With
the
rapid
development
of
nanotechnology,
constructing
a
multifunctional
nanoplatform
that
can
deliver
various
therapeutic
agents
in
different
departments
and
respond
to
endogenous/exogenous
stimuli
for
multimodal
synergistic
cancer
therapy
remains
major
challenge
address
inherent
limitations
chemotherapy.
Methods:
Herein,
we
synthesized
hollow
mesoporous
Prussian
Blue@zinc
phosphate
nanoparticles
load
glucose
oxidase
(GOx)
DOX
(designed
as
HMPB-GOx@ZnP-DOX
NPs)
non-identical
pore
structures
their
HMPB
core
ZnP
shell,
respectively,
photothermally
augmented
chemo-starvation
therapy.
Results:
The
shell
coated
on
core,
addition
providing
space
chemotherapy,
could
also
serve
gatekeeper
protect
GOx
from
premature
leakage
inactivation
before
reaching
tumor
site
because
its
degradation
characteristics
under
mild
acidic
conditions.
Moreover,
loaded
initiate
starvation
by
catalyzing
oxidation
while
causing
an
upgradation
acidity
H
2
O
levels,
which
be
used
forceful
endogenous
trigger
smart
delivery
systems
applications.
decrease
pH
improve
pH-sensitivity
drug
release,
supplied
decomposing
through
catalase-like
activity
HMPBs,
is
beneficial
relieving
adverse
conditions
anti-tumor
activity.
In
addition,
inner
acts
photothermal
agent
generated
hyperthermia
upon
laser
irradiation
external
stimulus
further
promote
release
enzymatic
activities
GOx,
thereby
enabling
synergetic
enhanced
effect.
Importantly,
these
results
indicate
NPs
effectively
inhibit
growth
80.31%
exhibit
no
obvious
systemic
toxicity
mice.
Conclusion:
employed
potential
theranostic
incorporate
multiple
modes
efficiently
tumors.
Keywords:
Blue,
oxidase,
co-delivery
system,
therapy,
chemotherapy
