International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(6)
Published: Oct. 30, 2024
Aldehyde
dehydrogenase
1
family
member
A1
(ALDH1A1)
is
a
of
the
aldehyde
gene
subfamily
that
encode
enzymes
with
ability
to
oxidize
retinaldehyde.
It
was
recently
shown
high
ALDH1A1
RNA
abundance
correlates
poor
prognosis
in
acute
myeloid
leukemia
(AML).
AML
hematopoietic
malignancy
associated
morbidity
and
mortality
rates.
Although
there
are
number
agents
inhibit
ALDH
activity,
it
would
be
crucial
develop
methodologies
for
adjustable
genetic
interference,
which
permit
interventions
on
several
oncogenic
pathways
parallel.
Intervention
multiple
theoretically
possible
microRNAs
(miRNAs
or
miRs),
class
small
non‑coding
RNAs
have
emerged
as
key
regulators
expression
AML.
A
miRNAs
interfere
directly
solid
tumor
cells,
these
can
evaluated
model
systems.
There
indications
few
actually
do
an
association
disease
course,
rendering
them
promising
target
intervention
cells.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(10), P. 3859 - 3899
Published: Jan. 1, 2024
Osteoporosis
is
a
systemic
skeletal
disease
caused
by
an
imbalance
between
bone
resorption
and
formation.
Current
treatments
primarily
involve
medication
hormone
therapy.
However,
these
lack
directionality
are
often
ineffective
for
locally
severe
osteoporosis,
with
the
potential
complex
adverse
reactions.
Consequently,
treatment
strategies
using
bioactive
materials
or
external
interventions
have
emerged
as
most
promising
approaches.
This
review
proposes
twelve
microenvironmental
targets
osteoporosis-related
pathological
changes,
including
local
accumulation
of
inflammatory
factors
reactive
oxygen
species
(ROS),
mitochondrial
dynamics,
insulin
resistance,
disruption
cell
autophagy,
apoptosis,
changes
in
neural
secretions,
aging
cells,
increased
tissue
vascular
destruction,
decreased
regeneration.
Additionally,
this
examines
current
research
status
effective
biophysical
biochemical
stimuli
based
on
summarizes
advantages
optimal
parameters
different
bioengineering
to
support
preclinical
clinical
osteoporosis
Finally,
addresses
ongoing
challenges
future
prospects.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(15), P. 7657 - 7680
Published: Jan. 1, 2024
Nanomaterials
exhibit
significant
potential
for
stimulating
immune
responses,
offering
both
local
and
systemic
modulation
across
a
variety
of
diseases.
The
lymphoid
organs,
such
as
the
spleen
lymph
nodes,
are
home
to
various
cells,
including
monocytes
dendritic
which
contribute
progression
prevention/treatment
Consequently,
many
nanomaterial
formulations
being
rationally
designed
target
these
organs
engage
with
specific
cell
types,
thereby
inducing
therapeutic
protective
effects.
In
this
review,
we
explore
crucial
cellular
interactions
processes
involved
in
regulation
highlight
innovative
nano-based
immunomodulatory
approaches.
We
outline
essential
considerations
design
an
emphasis
on
their
impact
biological
interactions,
targeting
capabilities,
treatment
efficacy.
Through
selected
examples,
illustrate
strategic
therapeutically
active
nanomaterials
subsequent
immunomodulation
infection
resistance,
inflammation
suppression,
self-antigen
tolerance,
cancer
immunotherapy.
Additionally,
address
current
challenges,
discuss
emerging
topics,
share
our
outlook
future
developments
field.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: Feb. 25, 2025
Abstract
The
skeletal
system
comprises
closely
related
yet
functionally
distinct
bone
and
cartilage
tissues,
regulated
by
a
complex
network
of
transcriptional
factors
signaling
molecules.
Among
these,
core‐binding
factor
subunit
beta
(Cbfβ)
emerges
as
critical
co‐transcriptional
that
stabilizes
Runx
proteins,
playing
indispensable
roles
in
development
homeostasis.
Emerging
evidence
from
genetic
mouse
models
has
highlighted
the
essential
role
Cbfβ
directing
lineage
commitment
mesenchymal
stem
cells
(MSCs)
their
differentiation
into
osteoblasts
chondrocytes.
Notably,
deficiency
is
strongly
associated
with
severe
dysplasia,
affecting
both
endochondral
intramembranous
ossification
during
embryonic
postnatal
development.
In
this
review,
we
synthesize
recent
advancements
understanding
structural
molecular
functions
Cbfβ,
particular
focus
on
its
interactions
key
pathways,
including
BMP/TGF‐β,
Wnt/β‐catenin,
Hippo/YAP,
IHH/PTHrP.
These
pathways
converge
Cbfβ/RUNX2
complex,
which
orchestrates
gene
expression
program
for
osteogenesis,
formation,
integration
these
networks
ensures
precise
regulation
development,
remodeling,
repair.
Furthermore,
successful
local
delivery
to
address
abnormalities
underscores
potential
novel
therapeutic
target
disorders
such
cleidocranial
osteoarthritis,
metastases.
By
elucidating
mechanisms
underlying
function
insights
not
only
advance
our
biology
but
also
offer
promising
avenues
clinical
intervention,
ultimately
improving
outcomes
patients
disorders.
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125480 - 125480
Published: March 1, 2025
Developing
innovative
approaches
to
target
osteomyelitis
caused
by
polymicrobial
infections
remains
a
significant
therapeutic
challenge.
In
this
study,
monodispersed
chitosan
nanoparticles
co-loaded
with
antibacterial
(minocycline)
and
antifungal
(voriconazole)
agents
were
successfully
prepared.
Minocycline
presented
higher
encapsulation
efficiency
as
compared
voriconazole.
Thermostability
analysis
suggested
interactions
between
the
drugs
within
dual-delivery
system,
potentially
limiting
voriconazole
release.
The
dual-loaded
exhibited
in
vitro
anti-biofilm
activity,
achieving
up
90%
reduction
biofilms
of
S.
aureus
C.
albicans.
Additionally,
showed
cytocompatibility
human
osteoblast
cell
line.
These
findings
highlight
potential
chitosan-based
nanoparticle
system
address
critical
gap
treatment
targeting
both
bacterial
fungal
pathogens.
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(4), P. 362 - 362
Published: March 31, 2025
Active
targeting
nanoparticles
are
a
new
generation
of
drug
and
gene
delivery
systems
with
the
potential
for
greatly
improved
therapeutics
compared
to
conventional
nanomedicine
approaches.
Despite
their
potential,
translation
active
faces
challenges
in
production
scale-up
batch
consistency.
Accurate
quality
control
methods
nanoparticle
therapeutic
payload
coating
characterization
critical
attaining
desired
levels
repeatability,
drug/gene
loading
efficiency,
molecule
effectiveness,
safety
profiles.
Current
limitations
technologies,
such
as
relying
on
ensemble-average
analysis,
pose
assessing
content
surface
modification
heterogeneity,
which
can
affect
outcomes.
Single-molecule
analysis
technologies
have
emerged
promising
alternative,
offering
rich
information
heterogeneity
stochastic
variations
between
batches.
This
review
first
evaluates
identifies
traditional
tools
that
rely
indirect,
bulk
solution
quantification
methods.
Subsequently,
newly
emerging
introduced
targeted
moiety
efficiencies
single-nanoparticle
resolution,
help
guide
researchers
towards
advancing
into
clinical
setting.
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
190, P. 112413 - 112413
Published: April 5, 2024
Osteoporotic
osteoarthritis
(OP-OA)
is
a
severe
pathological
form
of
OA,
urgently
requiring
precise
management
strategies
and
more
efficient
interventions.
Emodin
(Emo),
an
effective
ingredient
found
in
the
traditional
Chinese
medicine
rhubarb,
has
been
dEmonstrated
to
promote
osteogenesis
inhibit
extracellular
matrix
degradation.
In
this
study,
we
aimed
investigate
interventional
effects
Emo
on
subchondral
bone
cartilage
knee
joints
OP-OA
model
rats.
Chemical Biology & Drug Design,
Journal Year:
2024,
Volume and Issue:
104(3)
Published: Sept. 1, 2024
ABSTRACT
Arctigenin
(Ar)
is
a
promising
therapeutic
candidate
for
postmenopausal
osteoporosis
(PMOP).
This
study
explores
its
mechanism
by
examining
effects
on
adipogenesis
and
osteogenesis
in
ovariectomized
(OVX)
rats.
In
vitro,
Ar
effectively
suppressed
the
adipogenic
differentiation
of
bone
marrow
mesenchymal
stem
cells
(BMSCs)
from
OVX
rats,
reducing
lipid
droplet
formation
downregulating
proteins
associated
with
synthesis.
vivo,
treatment
significantly
reduced
loss,
inhibited
adipocyte
development,
improved
metabolism,
promoted
Mechanistically,
phosphorylation
Mitogen‐Activated
Protein
Kinase
1
(MEK1),
downregulated
Peroxisome
Proliferator‐Activated
Receptor
gamma
(PPARγ),
accumulation
β‐catenin
nucleus,
prevented
direct
binding
PPARγ
to
BMSCs.
regulation
PPARγ/Wnt
signaling
axis
underlies
dual
role
inhibiting
promoting
osteogenesis.
Notably,
co‐treatment
rosiglitazone
(RGZ)
reversed
without
affecting
MEK1
inhibition.
These
findings
offer
valuable
insights
into
arctigenin's
potential
as
strategy
PMOP
modulating
regulating
axis.
Phytochemical Analysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 26, 2024
Abstract
Introduction
Osteoporosis,
one
of
the
common
bone
diseases,
manifests
itself
as
a
decrease
in
mass.
Recently,
use
medicinal
plants
search
for
effective
and
low‐toxicity
therapeutics
prevention
or
treatment
osteoporosis
has
become
trending
topic.
Objective
In
this
study,
we
aim
to
prepare
controlled
drug
carrier
system
loaded
with
Gypsophila
eriocalyx
determine
its
potential
anti‐osteoporosis
applications.
Methods
extract
(GEE)
was
prepared,
components
were
determined.
The
molecular
interactions
Cathepsin
K
(CatK),
which
is
used
target
development
against
osteoporosis,
revealed
by
silico
docking
MD
methods.
ADMET
profiles
also
examined.
GEE‐loaded
chitosan
nanoparticles
(CNPs)
synthesized.
nanoparticles'
morphology,
encapsulation
efficiency,
loading
capacity,
release
profile,
average
size,
polydispersity
index,
zeta
potentials
cytotoxic
effects
GEE
CNPs
on
L929
osteogenic
proliferation
human
marrow
stem
cells
(hBMC)
Results
analysis
no
breaks
atomic
changes
dynamic
system,
confirmed
continued
interaction
identical
residues.
It
determined
that
CNP
formulation
produced
successfully,
had
toxic
effect
L929,
an
hBMC.
Conclusion
line
vitro
results
obtained,
it
evaluated
can
be
candidate
phytotherapeutic
properties
treatment.q1
