Published: Dec. 9, 2024
Language: Английский
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 3, 2025
Abstract Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate plant-derived nanoparticles (PNP) on and metabolites in context cancer immunotherapy with humanized gnotobiotic mouse model. Specifically, show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae Lactobacillaceae mediated digalactosyldiacylglycerol (DGDG) glycine, respectively. We further demonstrate GELN aly-miR159a-3p enhances anti-PD-L1 therapy melanoma inhibiting expression recipient bacterial phospholipase C (PLC) increases accumulation docosahexaenoic acid (DHA). An increased level circulating DHA inhibits PD-L1 tumor cells binding promoter subsequently prevents c-myc-initiated transcription PD-L1. Colonization germ-free male mice bacteria from non-responding patients supplemented efficacy compared controls. Our findings reveal previously unknown mechanistic PNP human modulating metabolic pathways.
Language: Английский
Citations
4
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 17, 2024
The discovery of novel and innovative therapeutic strategies for cancer treatment management remains a major global challenge. Exosomes are endogenous nanoscale extracellular vesicles that have garnered increasing attention as vehicles advanced drug delivery targeted therapy. attractive physicochemical biological properties exosomes, including increased permeability, biocompatibility, extended half-life in circulation, reduced toxicity immunogenicity, multiple functionalization strategies, made them preferred other diseases. Small interfering RNAs (siRNAs) remarkably able to target any known gene: an attribute harnessed knock down cancer-associated genes viable strategy management. Extensive research on exosome-mediated siRNAs targeting diverse types has yielded promising results anticancer therapy, with some formulations progressing through clinical trials. This review catalogs recent advances siRNA several cancer, the manifold benefits minimal drawbacks such systems. Additionally, we highlighted potential plant-derived exosomes systems treatment, offering numerous advantages scalability, compared traditional methods. These their unique characteristics effective delivery, represent significant advancement nanomedicine therapeutics. Further exploration manufacturing processes mechanisms could significantly advance natural medicine enhance efficacy exosome-based therapies.
Language: Английский
Citations
7
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130776 - 130776
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Bone fractures, especially large and complex defects, continue to pose significant challenges in the medical field. Current treatments often rely on autografts or allografts for structural support, which can lead problems such as reduced bioactivity, infection risks, potential pathogen transmission. Nature herbal medicine (NHM), including herbs extracts, offers a promising alternative by effectively modulating inflammatory responses, enhancing osteoblast function, inhibiting bone resorption, thereby facilitating fracture repair. However, traditional drug delivery methods NHM encounter interactions, poor tissue distribution, patient compliance. Biomaterials, engineered interact with biological systems, play essential roles repair, mechanical delivery. When used carriers, biomaterials be combined form stable systems that further promote regeneration. Here applications of are reviewed, hydrogels, extracellular vesicles, cement, conjunction regulating homeostasis aiming provide valuable insights guidance future research therapeutic strategies.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Citations
0
Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100597 - 100597
Published: Feb. 1, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13565 - 13576
Published: Feb. 24, 2025
Skin trauma often results from pain, swelling, and scarring can significantly interfere with daily activities. Extracts the American cockroach, a rapidly reproducing insect, have been recognized for therapeutic properties in wound management. Traditional extraction methods use solvents such as ethanol to obtain active compounds, but these may compromise intrinsic biological of cockroach extracts. In this study, we investigated nanovesicles isolated fresh cockroaches skin treatment focused on their characteristics efficacy. Fresh dried (F-ACNVs D-ACNVs, respectively) were procured via ultrahigh-speed centrifugation. We found that F-ACNVs exhibited superior cell proliferation-promoting activity. By employing metabolomics, proteomics, long noncoding RNA (lncRNA) omics, identified rich repertoire metabolites, proteins, lncRNAs within F-ACNVs. vitro vivo experiments demonstrated enhanced proliferation migration human umbilical vein endothelial cells (HUVECs) keratinocytes (HACATs) well repair mechanical trauma. These effects be mediated through activation angiogenic signaling pathways. Our research introduces novel strategy treating offers insight into medicinal potential insects while emphasizing importance preserving optimal outcomes.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Pharmaceutical Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 588 - 588
Published: April 26, 2024
A wide variety of natural bioactive compounds derived from plants have demonstrated significant clinical relevance in the treatment various diseases such as cancer, chronic disease, and inflammation. An increasing number studies surfaced that give credence to potential plant-derived vesicle-like nanoparticles (PDVLNs) compelling candidates for a drug delivery system (DDS). PDVLNs are cost-effective production, non-toxicity non-immunogenicity fascinating bi-ocompatibility. In this review, we attempt comprehensively review consolidate position next-generation nanoplatforms. We aim quick glance readers current developments PDVLNs, including their biogenesis, characteristic features, composition, administration routes, advantages, application. Further, discuss advantages limitations PDVLNs. expect role will be significantly enhanced, thus positioning them next generation therapeutic modalities foreseeable future.
Language: Английский
Citations
3