Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101440 - 101440
Published: Dec. 31, 2024
Language: Английский
Science Advances, Journal Year: 2025, Volume and Issue: 11(9)
Published: Feb. 26, 2025
Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.
Language: Английский
Citations
2
Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: Jan. 16, 2025
Introduction Cardiovascular disease (CVD) is the leading cause of death worldwide. Platelet-derived extracellular vesicles (PEV) have attracted extensive attention in cardiovascular research recent years because their cargo involved a variety pathophysiological processes, such as thrombosis, immune response, promotion or inhibition inflammatory angiogenesis well cell proliferation and migration.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 960 - 960
Published: Aug. 7, 2024
Cardiovascular diseases (CVDs) are one of the leading causes death worldwide. Despite significant advances in current drug therapies, issues such as poor targeting and severe side effects persist. In recent years, nanomedicine has been extensively applied research treatment CVDs. Among these, biomembrane-modified biomimetic nanodrug delivery systems (BNDSs) have emerged a focus due to their unique biocompatibility efficient capabilities. By modifying with biological membranes, BNDSs can effectively reduce recognition clearance by immune system, enhance circulation time vivo, improve targeting. This review first provides an overview classification pathological mechanisms CVDs, then systematically summarizes progress discussing design principles, functional characteristics, clinical application potential. Finally, it highlights challenges faced translation BNDSs.
Language: Английский
Citations
5
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 21, 2024
Abstract Extracellular vesicles (EVs) are cell-derived with a phospholipid bilayer measuring 50–150 nm in diameter demonstrated therapeutic potentials. Limitations such as the natural biodistribution (mainly concentrated liver and spleen) short plasma half-life of EVs present significant challenges to their clinical translation. In recent years, growing research indicated that engineered enhanced targeting lesion sites have markedly promoted efficacy. However, there is dearth systematic knowledge on advances engineering for targeted delivery. Herein, we provide an overview mechanisms, techniques, translations applications. Enrichment at may be achieved through recognition tissue markers, pathological changes, circumvention mononuclear phagocyte system (MPS). Alternatively, external stimuli, including magnetic fields ultrasound, also employed. EV techniques fulfill functions includes genetic engineering, membrane fusion, chemical modification physical modification. A comparative statistical analysis was conducted elucidate discrepancies between diverse size, morphology, stability, efficacy vitro vivo. Additionally, summary registered trials utilizing from 2010 2023 has been provided, full discussion perspectives. This review provides comprehensive mechanisms associated delivery applications advocate further explorations accelerate
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156581 - 156581
Published: March 13, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Periprosthetic osteolysis (PPOL) is a serious complication following total joint replacement surgery, and exploring treatments for this of significant societal importance. Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos, Exos) have diverse cellular functions, such as inhibiting osteoclast formation, suppressing inflammation progression, promoting M2 macrophage polarization. However, standalone are easily recognized phagocytosed by the immune system, short half-life, lack specificity. This study based on homing effect possessed macrophages under regulation various factors. By combining with cell membrane encapsulation technology embedding BMSC-Exos within (M2M-Exos), aim to inhibit treat PPOL. It was found that M2M-Exos can target PPOL area, enhancing therapeutic effects reducing wear particle-induced cranial osteolysis. Additionally, provide camouflage through membrane, allowing evade clearance mononuclear system in body. Therefore, demonstrates targeting ability their unique role preventing These biomimetic nanoparticles establish targeted nanodrug delivery treatment.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 17, 2025
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 171 - 188
Published: April 8, 2025
Language: Английский
Citations
0
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: May 5, 2025
Abstract Cardiovascular diseases (CVDs) represent a profound challenge with inflammation playing significant role in their pathophysiology. Extracellular vesicles (EVs), which are membranous structures encapsulated by lipid bilayer, essential for intercellular communication facilitating the transport of specific bioactive molecules, including microRNAs, proteins, and lipids. Emerging evidence suggests that regulatory mechanisms governing cardiac resident cells influenced EVs, function as messengers thereby contribute to advancement CVDs. In this review, we discuss multifaceted biological functions EVs involvement pathogenesis various CVDs, encompassing myocardial infarction, ischemia–reperfusion injury, heart failure, atherosclerosis, myocarditis, cardiomyopathy, aneurysm. Furthermore, summarize recent advancements utilizing non-invasive biomarkers cell-free therapy based on diagnosis treatment Future research should investigate effective techniques isolation purification from body fluids, while also exploring pathways clinical translation EVs. Additionally, it is imperative identify appropriate EV-miRNA profiles or combinations present circulation patients, could serve improve diagnostic accuracy By synthesizing integrating findings, review aims provide innovative perspectives CVDs potential therapeutic strategies.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101440 - 101440
Published: Dec. 31, 2024
Language: Английский
Citations
3