Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs DOI
Peng Wang,

Xiao Di,

Fengshi Li

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) been identified key promoter of therapeutic angiogenesis, its clinical application is limited due to short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These demonstrated enhanced capabilities promote endothelial cell (EC) proliferation, migration, tube formation in vitro. Additionally, their efficacy improving tissue perfusion promoting was confirmed hindlimb ischemia rat model. Our findings suggest that HGF-PLGA-NPs could serve promising approach enhancing restoring conditions.

Language: Английский

Nanoparticle-Doped Antibacterial and Antifungal Coatings DOI Open Access
Devyani Thapliyal, George D. Verros, Raj Kumar Arya

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 247 - 247

Published: Jan. 20, 2025

Antimicrobial polymeric coatings rely not only on their surface functionalities but also nanoparticles (NPs). gain properties from the addition of NPs into a matrix. that have been used include metal-based NPs, metal oxide carbon-based nanomaterials, and organic NPs. Copper silver exhibit antibacterial antifungal properties. So, when present in coatings, they will release ions with combined effect having bacteriostatic/bactericidal properties, preventing growth pathogens surfaces covered by these nano-enhanced films. In addition, such as titanium dioxide (TiO2 NPs) zinc (ZnONPs) are antimicrobial coatings. Under UV irradiation, show photocatalytic lead to production reactive oxygen species (ROS) exposed radiation. After various forms nano-carbon materials were successfully developed over past decade, derivatives graphite/nanotubes, composite sheets receiving more attention because share an extremely large area, excellent mechanical strength, etc. These ability cause oxidative stress chemicals under control, resulting long-lasting action. The effectiveness life spans antifouling performance variety improved adding nano-sized particles those

Language: Английский

Citations

3
Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development DOI
Yanlin Jiang, Yu Cao, Yiqun Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

Citations

1
Recent advances in polymeric nanoparticles for the treatment of hepatic diseases DOI Creative Commons
Feng Gao,

Xuefei Feng,

Xinyu Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, fibrosis, cancer, have posed a significant threat to global health, emphasizing the critical need for development of novel effective treatment approaches. Nanotechnology, an emerging technology, has been extensively researched medicine. Among many types nanomaterials, polymeric nanoparticles (NPs) are widely used drug delivery systems. Compared traditional therapies, they offer advantages disease by improving outcomes reducing side effects. This review introduced discussed application natural polymers synthetic their management. Furthermore, this paper reviewed -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) poly (lactic-co-glycolic acid) (PLGA)-in treatment, focusing on use various systems pure bioactive compounds origin, drugs, nucleic acids, peptides, others. Finally, challenges future perspectives NPs were provide guidance further research directions, with aim promoting clinical nanotherapeutics treating hepatic diseases.

Language: Английский

Citations

1
Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study DOI

Büşra Solak,

Pervin Soyer, Elif Kaya Tilki

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106721 - 106721

Published: Feb. 1, 2025

Language: Английский

Citations

1
Arginine deiminase-polymeric hybrid nanoconjugates: A potential biodrug for targeted treatment of arginine auxotrophic cancers DOI
Anubhuti Kawatra, Pooja Gulati

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143679 - 143679

Published: May 1, 2025

Language: Английский

Citations

0
Re-purposing of Linagliptin for enhanced wound healing and skin rejuvenation via chitosan- modified PLGA Nanoplatforms DOI
Fatma Sa’eed El-Tokhy, Dina O Helal, Sherif S. Abdel Mageed

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 677, P. 125664 - 125664

Published: May 1, 2025

Language: Английский

Citations

0
Inducing disulfidptosis in tumors:potential pathways and significance DOI Creative Commons
Tao Mi, Xiangpan Kong, Meiling Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 15, 2024

Regulated cell death (RCD) is crucial for the elimination of abnormal cells. In recent years, strategies aimed at inducing RCD, particularly apoptosis, have become increasingly important in cancer therapy. However, ability tumor cells to evade apoptosis has led treatment resistance and relapse, prompting extensive research into alternative processes A study identified a novel form RCD known as disulfidptosis, which linked disulfide stress. Cancer import cystine from extracellular environment via solute carrier family 7 member 11 (SLC7A11) convert it cysteine using nicotinamide adenine dinucleotide phosphate (NADPH). When NADPH deficient or its utilization impaired, accumulates, leading formation bonds actin cytoskeleton, triggering disulfidptosis. Disulfidptosis reveals metabolic vulnerability tumors, offering new insights therapy strategies. This review provides detailed overview mechanisms underlying current progress, limitations. It also highlights innovative disulfidptosis explores potential combining these approaches with traditional therapies, immunotherapy, expedite clinical translation.

Language: Английский

Citations

2
Co-delivery of vinorelbine and rutin by lipid polymer nanoparticles for enhanced liver cancer chemotherapy DOI
Bader B. Alsulays, Md. Khalid Anwer, Faisal Imam

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106490 - 106490

Published: Dec. 1, 2024

Language: Английский

Citations

1
Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs DOI
Peng Wang,

Xiao Di,

Fengshi Li

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) been identified key promoter of therapeutic angiogenesis, its clinical application is limited due to short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). These demonstrated enhanced capabilities promote endothelial cell (EC) proliferation, migration, tube formation in vitro. Additionally, their efficacy improving tissue perfusion promoting was confirmed hindlimb ischemia rat model. Our findings suggest that HGF-PLGA-NPs could serve promising approach enhancing restoring conditions.

Language: Английский

Citations

1