Recent advances in polymeric nanoparticles for the treatment of hepatic diseases

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, fibrosis, cancer, have posed a significant threat to global health, emphasizing the critical need for development of novel effective treatment approaches. Nanotechnology, an emerging technology, has been extensively researched medicine. Among many types nanomaterials, polymeric nanoparticles (NPs) are widely used drug delivery systems. Compared traditional therapies, they offer advantages disease by improving outcomes reducing side effects. This review introduced discussed application natural polymers synthetic their management. Furthermore, this paper reviewed -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) poly (lactic-co-glycolic acid) (PLGA)-in treatment, focusing on use various systems pure bioactive compounds origin, drugs, nucleic acids, peptides, others. Finally, challenges future perspectives NPs were provide guidance further research directions, with aim promoting clinical nanotherapeutics treating hepatic diseases.

Language: Английский

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Harnessing the Power of Traditional Chinese Medicine in Cancer Treatment: The Role of Nanocarriers

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3147 - 3174

Published: March 1, 2025

For centuries, traditional Chinese medicine (TCM) has had certain advantages in the treatment of tumors. However, due to their poor water solubility, low bioavailability and potential toxicity, effective delivery target sites can be a major challenge. Nanocarriers based on active ingredients TCM, such as liposomes, polymer nanoparticles, inorganic organic/inorganic nanohybrids, are promising strategy improve resulting higher therapeutic outcomes fewer side effects. Therefore, this article intends review application nano preparation tumor. Firstly, we introduce classification synthesis nanometer preparations medicine. The second part mainly introduces different responses TCM nano-preparations course how play role anti-tumor therapy. third focuses Different response modes tumor fourth elucidates cancer. Finally, research direction explored related fields is put forward.

Language: Английский

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Pharmaceutical and experimental-clinical aspects of photodynamic therapy combined with chemotherapy for malignant and premalignant tumors

Siberian Journal of Oncology, Journal Year: 2025, Volume and Issue: 24(1), P. 142 - 149

Published: March 18, 2025

The aim of the study was to analyze effectiveness experimental and clinical photodynamic therapy combined with chemotherapy in treatment malignant premalignant lesions. Material methods . WoS, Scopus, MedLine, RSCI databases have been searched analyzed on this issue, mainly over past 7 years. We found 288 sources pharmaceutical experimental-clinical studies combination compare therapeutic effects monotherapy, which 50 were included review. Results Photodynamic is a new cancer technology that has become increasingly common recent In some cases, it often an alternative method treating when there high risk side complications during traditional treatments such as surgery, radiation chemotherapy. review summarized current aspects performing Despite fact gives best results neoplasms, strategy limitations. One major challenges very little research conducted field. Additional also needed understand mechanisms increasing therapy. challenge reaching effectively deeper tissues remains significant obstacle wider application Therefore, further determine most effective photosensitizers technologies for using non-ionizing radiation. review, we shown strategies nanopharmaceuticals, demonstrated encouraging results. Conclusion improved efficacy reduced deserve comprehensive study.

Language: Английский

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Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

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Hepatoma-Targeting and ROS-Responsive Polymeric Micelle-Based Chemotherapy Combined with Photodynamic Therapy for Hepatoma Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9613 - 9635

Published: Sept. 1, 2024

The combination of nanoplatform-based chemotherapy and photodynamic therapy (PDT) is a promising way to treat cancer. Celastrol (Cela) exhibits highly effective anti-hepatoma activity with low water solubility, poor bioavailability, non-tumor targeting, toxic side effects. Cela-based PDT via hepatoma-targeting reactive oxygen species (ROS)-responsive polymeric micelles (PMs) could solve the application problem Cela further enhance antitumor efficacy.

Language: Английский

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