Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

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Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC)

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.

Language: Английский

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Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651

Published: Dec. 1, 2024

Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.

Language: Английский

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Exploring the Potential of Plant-Based Nanotechnology in Cancer Immunotherapy: Benefits, Limitations, and Future Perspectives

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Language: Английский

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