Nano-spanlastics-loaded dissolving microneedle patches for ketotifen fumarate: advanced strategies for allergic conjunctivitis treatment and molecular insights

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

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Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerate cachectic wound healing and reduce scar hyperplasia

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123378 - 123378

Published: Feb. 18, 2025

Language: Английский

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A Multi‐Responsive Hydrogel Combined With Mild Heat Stimulation Promotes Diabetic Wound Healing by Regulating Inflammatory and Enhancing Angiogenesis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract The repair of diabetic wound still encounters huge challenges, such as disordered inflammatory regulation and impaired neovascularization. Here, a pH/ROS/glucose responsive photothermal hydrogel is developed for healing. formed through cross‐linkage between phenylboronic acid‐modified carboxymethyl chitosan (CMCS‐PBA) oxide dextran (OXD), utilizing Schiff base phenylboronate ester bonds. Additionally, insulin‐like growth factor 1 C domain (IGF‐1C) deferoxamine‐loaded polydopamine nanoparticles (D@P) are incorporated into the hydrogel. demonstrates sustained drug release, excellent photo thermal effect, prominent antioxidant, antibacterial anti‐inflammatory activities, desirable mechanical tissue adhesive properties, enhanced tube formation, cell migration. Furthermore, combined with mild heat treatment can regulate chronic inflammation by promoting transformation macrophages from M1 phenotype to M2 enhance angiogenesis up‐regulating expression levels angiogenesis‐related factors hypoxia‐inducible factor‐1 alpha (HIF‐1α), vascular endothelial (VEGF), CD31, α‐SMA, thus greatly accelerates healing in streptozotocin (STZ)‐induced mice. Therefore, this multi‐responsive multifunctional holds potential therapeutic strategy wounds.

Language: Английский

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Intranasal Bilosomes in Thermosensitive Hydrogel: Advancing Desvenlafaxine Succinate Delivery for Depression Management

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: 29(7), P. 663 - 674

Published: July 5, 2024

Depression, the second biggest cause of disability worldwide, is widespread. Many antidepressant medications, including Desvenlafaxine Succinate (D.V.S.), function by elevating neurotransmitter levels at synapse through inhibition reabsorption neurons. However, effectiveness these treatments often limited their inability to reach brain using conventional administration methods. Bilosome-stabilized nanovesicles containing bile salts have drawn much interest because adaptability and versatility in various applications. This study aimed address this issue formulating intranasal bilosomes incorporated into a mucoadhesive in-situ gel deliver D.V.S. directly for depression treatment. The desvenlafaxine-loaded were developed thin film hydration method based on l-optimal design. They intended provide more convenient route antidepressants, enhancing bioavailability targeting delivery. assessed optimized particle size (311.21 ± 0.42 nm), Zeta potential (-37.35 0.43)and encapsulation efficiency (99.53 0.41%) further evaluated them ex vivo pharmacokinetics studies. Pharmacokinetic data reveal enhanced uptake compared free drug. A statistically bilosome formulation was determined. Succinate-loaded facilitated direct nose-to-brain drug delivery, improving bioavailability.

Language: Английский

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Enhanced Antibacterial Activity of Clindamycin Using Molecularly Imprinted Polymer Nanoparticles Loaded with Polyurethane Nanofibrous Scaffolds for the Treatment of Acne Vulgaris

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 947 - 947

Published: July 17, 2024

Acne vulgaris, a prevalent skin condition, arises from an imbalance in flora, fostering bacterial overgrowth. Addressing this issue, clindamycin molecularly imprinted polymeric nanoparticles (Clin-MIP) loaded onto polyurethane nanofiber scaffolds were developed for acne treatment. Clin-MIP was synthesized via precipitation polymerization using methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), and azoisobutyronitrile (AIBN) as functional monomers, crosslinkers, free-radical initiators, respectively. MIP characterization utilized Fourier-transform infrared spectroscopy (FTIR) transmission electron microscopy (TEM) before being incorporated into nanofibers through electrospinning. Further analysis involved FTIR, scanning (SEM), vitro release studies, ex vivo study. showed strong antibacterial activity against S. aureus, with inhibitory concentration (MIC) minimum bactericidal (MBC) values of 0.39 6.25 μg/mL, It significantly dropped the count 1 × 108 to 39 101 CFU/mL has within 180 min incubation vitro. The pharmacodynamic histopathology studies revealed significant decrease infected animal inflammation, epidermal hypertrophy, congestion upon treatment reduced pro-inflammatory cytokines (NLRP3, TNF-α, IL-1β, IL-6) conducive healing. Consequently, recently created nanofibrous scaffold. This innovative approach offers insight creating materials several uses treating infectious wounds caused by acne.

Language: Английский

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Enhanced Intranasal Delivery of Atorvastatin via Superparamagnetic Iron-Oxide-Loaded Nanocarriers: Cytotoxicity and Inflammation Evaluation and In Vivo, In Silico, and Network Pharmacology Study for Targeting Glioblastoma Management

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 421 - 421

Published: March 16, 2025

Objective: This study aims to develop an intranasal (IN) delivery system for glioblastoma multiforme (GBM) management using repurposed superparamagnetic iron-oxide (SPION) loaded with atorvastatin (ATO)-nanostructured lipid carrier (NLC). Methods: Emulsification and ultrasonication were used formulate ATO-NLCs, the best formula was SPION make final atorvastatin/superparamagnetic iron oxide-loaded nanostructured (ASN) formulation. Entrapment efficiency (EE%), particle size (PS), zeta potential (ZP), drug release after 6 h (Q6h) evaluated NLCs. ASN tested cytotoxicity on T98G cancer cells, cell cycle examined determine death. Furthermore, ability of optimal formulation suppress levels inflammatory biomarkers investigated in Lipopolysaccharide (LPS)-induced inflammation. The brain-targeting behavior IN-ASN visualized rabbits via confocal laser scanning microscopy (CLSM). Results: optimum NLC exhibited a spherical shape, EE% 84.0 ± 0.67%, PS 282.50 0.51 nm, ZP −18.40 0.15 mV, Q6h 89.23%. against cells 4.4-fold higher than ATO suspension, 1.3-fold increment apoptosis. showed significantly reduced pro-inflammatory (IL-β, IL-6, TNF-α, TLR4, NF-қB), whereas CLSM revealed enhanced brain no observed histopathological nasal irritation. silico analysis demonstrated ATO-ADME (absorption, distribution, metabolism, excretion) properties, while network pharmacology identified 10 target GBM genes, among which MAPK3 most prominent good binding score as elucidated by simulated docking study. Conclusions: These findings may present ATO/SPION-NLCs significant evidence repurposing treatment multiforme.

Language: Английский

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Alchemy in Nature: The Role of Lawsonia inermis Extract Choice in Crafting Potent Anticancer Metal Nanoparticles

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Phyto-nanotechnology provides an eco-friendly approach for synthesizing biocompatible metal nanoparticles (NPs) with therapeutic potential.

Language: Английский

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The role of cytokines in wound healing: from mechanistic insights to therapeutic applications

Exploration of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Wound healing is an area of growing importance in the healthcare field, especially chronic wounds associated with comorbidities like diabetes mellitus (DM), hypoxic stress, obesity, and malnutrition. Chronic significantly increase costs reduce patients’ quality life. Cytokines are a promising therapeutic target, as they regulate all stages wound healing, dysfunction cytokine production can cause inflammatory non-healing wounds. Interleukin-1 (IL-1), IL-2, IL-6, IL-8, tumour necrosis factor-α (TNF-α) facilitate leukocyte recruitment clear dead cells during initial inflammation stage while transforming growth factor-β (TGF-β), IL-4, IL-13 inhibit stimulate proliferation fibroblasts to begin extracellular matrix (ECM) deposition. Given complexity interactions their diverse cellular targets, comprehensive understanding these signaling pathways crucial. This review examines multifaceted roles cytokines discusses recent advancements application modulation for improved care outcomes. Despite significant improving specificity therapies, further research needed focus on targeting downstream or specific receptors minimize adverse effects treatments.

Language: Английский

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Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats

Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Purpose This study aimed to develop a transdermal delivery system for fluocinolone acetonide (FLA), corticosteroid used in treating inflammatory conditions like rheumatoid arthritis (RA), overcome the limitations of oral administration, such as poor solubility and bioavailability. Methods FLA-loaded PEG decorated hyalurosomes (FLA-PHs) were fabricated using ethanol injection, incorporating various Brij® surfactants different amounts hyaluronic acid (HA) based on full factorial design. The impact independent variables, HA amount (mg) (X 1 ) Brij type 2 inspected entrapment efficiency (EE%), particle size (PS), zeta potential (ZP). optimum FLA-PHs then incorporated into ε-polycaprolactone (PCL) cellulose acetate (CA) nanofibers enhance sustained (FLA-NFs). Results exhibited EE% 83.58 ± 0.69%, PS 169.00 1.41 nm, ZP -22.90 0.14 mV. Morphological assessment FLA-NFs showed promising results terms surface roughness. In Freund-induced rat model adjuvant-induced arthritis, treatment with significantly improved joint histopathological analyses. Furthermore, it suppressed markers mTORC1, TNF-α, NF-κB while upregulating TRIM24 anti-inflammatory IL-10. Conclusion present strategy enhancing FLA managing RA, offering improvements efficacy reduced systemic side effects compared conventional administration.

Language: Английский

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Biogenic Zinc Oxide Nanoparticles as a Promising Antibacterial Agent: Synthesis and Characterization

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9500 - 9500

Published: Aug. 31, 2024

Nanotechnology has gained popularity in recent years due to its wide-ranging applications within the scientific community. The three main methods for synthesizing nanoparticles are physical, chemical, and biological. However, adverse effects associated with physical chemical have led a growing interest biological methods. Interestingly, green synthesis using plants prominence developing new treatments bacterial infections. Zinc oxide (ZnO NPs) produced environmentally friendly more biocompatible potential as antibacterial agents biomedical field. As result, this review discusses of ZnO NPs, factors influencing optimal synthesis, characterization techniques, activity some plant-mediated NPs. It also provides comprehensive analytical exploration NP biosynthesis, role phytochemical compounds reducing stabilizing agents, mechanism action their properties further highlights challenges prospects innovative research area.

Language: Английский

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